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2025
M. Streiber, N. E. Göppert, V. Bachmann, B. Schulze, R. Gläßer, I. Anufriev, P. Schädel, I. Nischang, C. Weber, O. Werz, U. S. Schubert, A. Traeger Tailoring cationic poly(2-oxazoline)s: Minimizing toxicity and immunogenic response for biological applicationsExternal link Mater. Today Chem. 2025 , 44 , 102549.
I. Anufriev, T. Klein, S. Hoeppener, J. C. Brendel, I. Nischang Supramolecular polymer bottlebrushes: In situ assessment of noncovalent assemblies in human serum by analytical ultracentrifugationExternal link Macromol. Rapid Commun . 2025 , 46 , 2400890.
V. H. P. Carrillo, J. J. Whittaker, C. Wiedemann, J. M. Harder, T. Lohr, A. K. Jamithireddy, M. Dajka, B. Goretzki, B. Joseph, A. Guskov, N. J. Harmer, U. Holzgrabe, U. A. Hellmich Structure and dynamics of macrophage infectivity potentiator proteins from pathogenic bacteria and protozoans bound to fluorinated pipecolic acid inhibitorsExternal link J. Med. Chem. 2025 , 68 , 5926-5941.
Y. F. Chen, F. Arendt, H. Bornhoeft, A. S. S. de Camargo, J. Deubener, A. Diegeler, S. Gogula, A. T. C. Jaimes, S. Kempf, M. Kilo, R. Limbach, R. Mueller, R. Niebergall, Z. W. Pan, F. Puppe, S. Reinsch, G. Schottner, S. Stier, T. Waurischk, L. Wondraczek, M. Sierka Ontology-based digital infrastructure for data-driven glass developmentExternal link Adv. Eng. Mat. 2025 , 27 , 2401560.
E. Colarusso, G. Lauro, M. Potenza, P. Galatello, M. L. D. Garigliota, M. G. Ferraro, M. Piccolo, M. G. Chini, C. Irace, P. Campiglia, R. K. Hoffstetter, O. Werz, A. Ramunno, G. Bifulco 5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidatesExternal link Arch. Pharm. (Weinheim) 2025 , 358 , e2400708.
A. Fruntke, J. Hulsmann, L. H. Skodda, B. Blumbott, M. Godmann, A. Koschella, T. Heinzel, T. Heinze, T. Wilke Polysaccharide-based nanoparticles prepared by dialysis: Novel drug deliveryExternal link J. Chem. Educ. 2025 , 102 , 1169-1178.
E. Gardey, J. C. Brendel, A. Stallmach Pathophysiology of IBD as a key strategy for polymeric nanoparticle developmentExternal link Adv. Therap. 2025 , 8 , 2400439.
S. Greiner, M. Ebrahimi, M. Rodewald, A. Urbanek, T. Meyer-Zedler, M. Schmitt, U. Neugebauer, J. Popp Characterizing metabolic shifts in septic murine kidney tissue using 2P-FLIM for early sepsis detectionExternal link Bioengineering 2025 , 12 , 170.
H. Koceva, M. Amiratashani, P. Akbarimoghaddam, B. Hoffmann, G. Zhurgenbayeva, M. S. Gresnigt, V. R. Marcelino, C. Eggeling, M. T. Figge, M. J. Amorim, A. S. Mosig Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axisExternal link Open. Biol. 2025 , 15 , 240231.
L. S. Reichel, A. Kemmer, T. Heinze, A. Traeger Design of pH-responsive and amphiphilic pullulan-based biological macromolecule for gene deliveryExternal link Int. J. Biol. Macromol. 2025 , 301 , 140014.
L. Xiong, D. Beyer, N. Liu, T. Lehmann, S. Neugebauer, S. Schaeuble, O. Sommerfeld, P. Ernst, C. M. Svensson, S. Nietzsche, S. Scholl, T. Bruns, N. Gassler, M. H. Gräler, M. T. Figge, G. Panagiotou, M. Bauer, A. T. Press Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical modelsExternal link Pharmacol. Res. 2025 , 212 , 107581.
T. Yalçin, P. M. Jordan, A. Olgaç, P. Dahlke, T. G. Maz, E. Banoglu, O. Werz, B. Çaliskan 2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitorsExternal link Arch. Pharm. 2025 , 358 , e2400756.
J. Schroeder, J. Westhoff, I. Vilotijević, O. Werz, S. Hoeppener, B. Löffler, D. Fischer, C. EhrhardtAnti-influenza activity of 6BIGOE: Improved pharmacological profile after encapsulation in plga nanoparticlesExternal link Int. J. Mol. Sci. 2025 , 26 , 4235.
K. Mehmetaj, W. Foo, Z. Cseresnyés, J. Plitzko, T. A. Shaik, Q. Ain, A. Ramoji, S. Huschke, L. Xiong, A. Zipprich, J. Popp, M. T. Figge, V. Deckert, S. Schubert, N. Gassler, F. H. Schacher, M. Bauer, A. T. Press Passively targeted polymeric nanocarrier delivering STAT1 siRNA to the liver ameliorates steatohepatitis and fibrosis in the thioacetamide mouse modelExternal link Biomaterials 2025 .
G. Lauro, M. Aliberti, M. De Nisco, S. Pedatella, G. Pepe, M. G. Basilicata, M. G. Chini, K. Fischer, R. K. Hofstetter, O. Werz, M. G. Ferraro, M. Piccolo, C. Irace, A. Saviano, P. Campiglia, A. Bertamino, C. Ostacolo, T. Ciaglia, M. Manfra, G. Bifulco Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibitionExternal link Eur. J. Med. Chem. 2025 , 289 , 117402.
C. T. Holick, T. Klein, C. Mehnert, F. Adermann, I. Anufriev, M. Streiber, L. Harder, A. Traeger, S. Hoeppener, C. Franke, I. Nischang, S. Schubert, U. S. Schubert Poly(2-ethyl-2-oxazoline) (POx) as poly(ethylene glycol) (PEG) lipid substitute for lipid nanoparticle formulationsExternal link Small 2025 , 21 , 2411354.
S. Bekemeier, C. R. Caldeira Rêgo, H. L. Mai, U. Saikia, O. Waseda, M. Apel, F. Arendt, A. Aschemann, B. Bayerlein, R. Courant, G. Dziwis, F. Fuchs, U. Giese, K. Junghanns, M. Kamal, L. Koschmieder, S. Leineweber, M. Luger, M. Lukas, J. Maas, J. Mertens, B. Mieller, L. Overmeyer, N. Pirch, J. Reimann, S. Schröck, P. Schulze, J. Schuster, A. Seidel, O. Shchyglo, M. Sierka, F. Silze, S. Stier, M. Tegeler, J. F. Unger, M. Weber, T. Hickel, J. Schaarschmidt Advancing digital transformation in material science: The role of workflows within the MaterialDigital initiativeExternal link Adv. Eng. Mat. 2025 , 27 , 2402149.
C. Ventura-Hunter, D. Pretzel, C. Kellner, S. Hoeppener, N. C. Roesner, P. Quintana-Owen, U. S. Schubert, G. Ayora-Talavera, E. Saldívar-Guerra, S. Fedeli, C. Guerrero-Sanchez Amphiphilic block copolymer conjugated with cell-penetrating-peptides derived from Influenza A H1N1 virus as a biocompatible scaffold for enhanced cell-uptakeExternal link Eur. Polym. J. 2025 , 229 , 113876.
M. Kötzsche, J. Egger, A. Dzierza, S. Reichel, I. Nischang, A. Traeger, D. Fischer, K. Peneva Making the negative positive – fluorination of indole as efficient strategy to improve guanidinium-containing gene carriersExternal link J. Mater. Chem. B 2025 .
S. Zhang, K. Schlabach, V. H. P. Carrillo, A. Ibrahim, A. Komor, R. Mukherji, S. Chowdhury, L. Reimer, F. Trottmann, C. Hertweck, U. A. Hellmich, P. StallforthA chemical radar allows bacteria to detect and kill predatorsExternal link Cell 2025 , 118 , 2495-2504.e20.
S. Sunoqrot, S. Abusulieh, I. Anufriev, P. Dahlke, P. M. Jordan, E. Al-Shalabi, C. T. Holick, S. Hoeppener, I. Nischang, O. Werz, S. Schubert, U. S. SchubertMild oxidation of plant polyphenols yields modular nanoparticle-forming materials with drug loading capabilitiesExternal link Macromol. Biosci. 2025 , 25 , 2400529.
A. Wallbraun, T. Wilke Vom erkrankten Organ zur gezielten Behandlung – Medikamenten-Taxis aus Nano-Kunststoffen im Unterricht untersuchenUnterricht Chemie 2025 , 207 , 36-42.
I. Parchmann, H. Rautenstrauch, T. Wilke, P. Wlotzka Medikamente und ihre Wirkstoffe - ein Thema auch für den ChemieunterrichtUnterricht Chemie 2025 , 207 , 2-8.
P. Wlotzka, T. Wilke Wirkstoffeigenschaften optimieren dank Polyethylenglyco l– Struktur-Eigenschaftsbeziehungen von KunststoffenUnterricht Chemie 2025 , 207 , 30-34.
T. Koswig, J. Kimmig, A. Vollrath, A. Träger, S. Zechel, U. S. Schubert Automatisierung, Robotik und künstliche Intelligenz - Auf dem digitalen Weg zu neuen MedikamentenUnterricht Chemie 2025 , 207 , 9-11.
X. Wang, A. Stihl, C. Höppener, J. Vitz, F. H. Schacher, V. DeckertNanoscale investigation of elasticity changes and augmented rigidity of block copolymer micelles induced by reversible core-cross-linkingExternal link ACS Appl. Mater. Int. 2025 , 17 , 27557-27567.
G. Perçin, K. Riege, J. Fröbel, J. Metz, S. Culemann, M. Lesche, S. Reinhardt, T. Höfer, S. Hoffmann, C. Waskow Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell poolExternal link Nat. Commun. 2025 , 16 , 4428.
L.-J. Jia, F. A. Bernal, J. Söhnlein, J. Sonnberger, I. Heineking, M. Rafiq, Z. Cseresnyés, F. Kage, F. Schmidt, R. Zaher, P. Hortschansky, S. Chaudhary, X. Gong, J. Schirawski, M. T. Figge, B. Hube, A. A. BrakhageConvergent evolution of a fungal effector enabling phagosome membrane penetrationExternal link bioRxiv 2025 .
J. Meyer, N. E. Göppert, L. M. Stafast, C. Weber, U. S. SchubertPolyesteracetals via TBD Catalyzed Ring-Opening PolymerizationExternal link Macromol. Rapid Commun. 2025 , e00273.
J. Schreiber, N. E. Göppert, L. M. Stafast, C. Weber, U. S. Schubert Cyclooctyne end-functionalized poly(morpholine-2,5-dione)sExternal link Macromol. Rapid Commun. 2025 , 46 , 2400705
C. G. Hernández-Valencia, C. M. Torre-Morales, R. I. Ortiz-Huidobro, M. Ramírez-Gilly, V. Martínez-López, J. Fernández-Torres, A. Tecante, R. Sánchez-Sánchez, A. Mazzetto, C. Guerrero-Sanchez, U. S. Schubert, M. Gimeno, Y. Zamudio-CuevasIntra-articular Injectable Poly(gallic acid) and Hyaluronic Acid Reduce Inflammation and Oxidative Stress for the Treatment of OsteoarthritisExternal link Int. J. Biological Macromol. 2025 , in press
L. Klement, J. Ismail, J. Schroeder, A. Godbole, J. Schreiber, C. Weber, Z. Cseresnyes, M. T. Figge, B. Löffler, U. S. Schubert, S. Schubert, C. Ehrhardt, C. Hoffmann Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM-I against influenza A Virus InfectionExternal link Adv. Healthc. Mater. 2025 , e04060
J. Schroeder, J. Ismail, C. T. Holick, J. Jungwirth, L. Klement, S. Hoeppener, C. Kosan, M. Schmidtke, B. Löffler, C. Weber, U. S. Schubert, C. Hoffmann, S. Schubert, C. Ehrhardt Advancing influenza virus treatment: in vitro and ex vivo studies of PI3K inhibitor-loaded lipid nanoparticlesExternal link Materials Today Bio 2025 , 35 , 102587.
2024
L. M. Stafast, M. Swieczkowski, P. Poudel, N. Engel, C. Yin, K. Scheuer, C. Weber, F. H. Schacher, K. D. Jandt, U. S. SchubertPOxylated stereocomplexes from PEtOx-b-PLA Diblock copolymersExternal link Eur. Polym. J. 2024 , 221 , 113545.
Y. Köster, J. Kimmig, S. Zechel, U. S. SchubertImplementation of the Polymerfingerprint: A molecular structure representation into an artificial neural networkExternal link STAR Protocols 2024 , 5 (2), 103055.
I. Lepori, Y. Oz, J. Im, N. Ghosh, M. Paul, U. S. Schubert, S. FedeliBioorthogonal “Click” cycloadditions: A toolkit for modulating polymers and nanostructures in living systemsExternal link Reactions 2024 , 5 (1), 231–245.
C. Yin, J. Hemstedt, K. Scheuer, M. Struczyńska, C. Weber, U. S. Schubert, J. Bossert, K. D. Jandt The effect of stereocomplexation and crystallinity on the degradation of polylactide nanoparticlesExternal link Nanomater . 2024 , 14 (5), 440.
M. Behnke, A. Vollrath, P. Dahlke, F. P. Larios, M. Chi, E. Tsarenko, P. M. Jordan, C. Weber, M. Dirauf, J. A. Czaplewska, B. Beringer-Siemers, S. Stumpf, C. Kellner, C. Kretzer, S. Hoeppener, I. Nischang, M. Sierka, C. Eggeling, O. Werz, U. S. Schubert, PEtOxylated polyesteramide nanoparticles for the delivery of anti-inflammatory drugsExternal link Mater. Today Chem . 2024 , 35 , 101848.
P. Zahel, V. Bruggink, J. Hülsmann, F. Steiniger, R. K. Hofstetter, T. Heinzel, U. Beekmann, O. Werz, D. KralischExploring microemulsion systems for the incorporation of glucocorticoids into bacterial cellulose: A novel approach for anti-inflammatory wound dressingsExternal link Pharmaceutics , 2024, 16 (4), 504.
X. Yao, S. Ehtesabi, C. Höppener, T. Deckert-Gaudig, H. Schneidewind, S. Kupfer, S. Gräfe, V. Deckert Mechanism of plasmon-induced catalysis of thiolates and the impact of reaction conditionsExternal link J. Am. Chem. Soc. 2024 , 146 (5), 3031-3042.
T. Wilke, M. Petersen, A. Fruntke Wissen aus dem Labor unterrichtsgerecht aufbereitenExternal link NadC . 2024 , 72 (2), 8-11.
M. Valentine, P. Rudolph, A. Dietschmann, A. Tsavou, S. Mogavero, S. Lee, E. L. Priest, G. Zhurgenbayeva, N. Jablonowski, S. Timme, C. Eggeling, S. Allert, E. Dolk, J. R. Naglik, M. T. Figge, M. S. Gresnigt, B.HubeNanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesisExternal link MBio. 2024 , 15 (3), e03409-23.
A.Seltmann, P. Carravilla, K. Reglinski, C. Eggeling, D. WaitheNeural network informed photon filtering reduces fluorescence correlation spectroscopy artifactsExternal link Biophys. J . 2024 , 123 (6), 745-755.
K. K.Schwickert, M. Glitscher, D. Bender, R. Murra, K. Schwickert, S. Pfalzgraf, T. Schirmeister, U. A. Hellmich, E. HildtLate stages of the Zika virus life cycle are impaired by a selective TRPML2 agonistExternal link bioRxiv 2024 , 578205.
S. Mikutis, S. Lawrinowitz, C. Kretzer, L. Dunsmore, L. Sketeris, T. Rodrigues, O. Werz, G. J. L. Bernardes Machine learning uncovers natural product modulators of the 5-lipoxygenase pathway and facilitates the elucidation of their biological mechanismsExternal link ACS Chem. Biol . 2024 , 19 (1), 217-229.
P. P. Mapfumo, J. I. Solomun, F. Becker, E. Moek, M. N. Leiske, L. K. Rudolph, J. C. Brendel, A. Traeger Vitamin B3 containing polymers for nanodeliveryExternal link Macromol. Biosci . 2024 , 24, 2400002.
P. P. Mapfumo, L. S. Reichel, S. Hoeppener, A. Traeger Improving gene delivery: Synergy between alkyl chain length and lipoic acid for PDMAEMA hydrophobic copolymersExternal link Macromol. Rapid Commun . 2024 , 45 (7), 2300649.
P. Manhas, C. Cokca, R. Sharma, K. Peneva, N. Wangoo, D. Sharma, R. K. SharmaChitosan functionalized doxorubicin loaded poly(methacrylamide) based copolymeric nanoparticles for enhanced cellular internalization and in vitro anticancer evaluationExternal link Int. J. Biol. Macromol . 2024 , 259 , 129242.
K. Leer, L. S. Reichel, M. Wilhelmi, J. C. Brendel, A. Traeger Tailoring gene transfer efficacy through the arrangement of cationic and anionic blocks in triblock copolymer micellesExternal link ACS Macro Lett . 2024 , 13 (2), 158-165.
K. Leer, L. S. Reichel, J. Kimmig, F. Richter, S. Hoeppener, J. C. Brendel, S. Zechel, U. S. Schubert, A. Traeger Optimization of mixed micelles based on oppositely charged block copolymers by machine learning for application in gene deliveryExternal link Small 2024 , 20 (6), 2306116.
K. Kowalczuk, A. Dasgupta, F. Páez Larios, H. F. Ulrich, V. Wegner, J. C. Brendel, C. Eggeling, A. S. Mosig, F. H. Schacher Self-degrading multifunctional PEG-based hydrogels—Tailormade substrates for cell cultureExternal link Macromol. Biosci . 2024 , 24 (5), 2300383.
S. König, J. Schroeder, S. Nietzsche, T. Heinekamp, A. A. Brakhage, R. Zell, B. Löffler, C. Ehrhardt The influenza A virus promotes fungal growth of Aspergillus fumigatus via direct interaction in vitroExternal link Microbes Infect . 2024 , 26 (3), 105264.
J. Joseph, L. Spantzel, M. Ali, J. D. Moonnukandathil , S. Unger, K. Reglinski, C. Krafft, A.-D. Müller, C. Eggeling, R. Heintzmann, M. Börsch, A. T. Press, D. Täuber Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR)External link Spectrochim Acta. A. Mol. Biomol. Spectrosc. 2024 , 306 , 123612.
P. M. Jordan, K. Günther, V. Nischang, Y. Ning, S. Deinhardt-Emmer, C. Ehrhardt, O. Werz Influenza A virus selectively elevates prostaglandin E(2) formation in pro-resolving macrophagesExternal link Iscience 2024 , 27 (1), 108775.
J. Ismail, L. C. Klepsch, P. Dahlke, E. Tsarenko, A. Vollrath, D. Pretzel, P. M. Jordan, K. Rezaei, J. A. Czaplewska, S. Stumpf, B. Beringer-Siemers, I. Nischang, S. Hoeppener, O. Werz, U. S. Schubert PEG-Lipid-PLGA hybrid particles for targeted delivery of anti-inflammatory drugsExternal link Pharmaceutics 2024 , 16 (2), 187.
E. Gardey, Z. Cseresnyes, F. H. Sobotta, J. Eberhardt, D. Haziri, P. C. Grunert, M. T. Kuchenbrod, F. V. Gruschwitz, S. Hoeppener, M. Schumann, N. Gaßler, M. T. Figge, A. Stallmach, J. C. Brendel Selective uptake into inflamed human intestinal tissue and immune cell targeting by wormlike polymer micellesExternal link Small 2024 , 20 (21), e2306482.
B. Farias-Mancilla, A. Balestri, J. Zhang, H. Frielinghaus, D. Berti, C. Montis, M. Destarac, U. S. Schubert, C. Guerrero-Sanchez, S. Harrisson, B. Lonetti Morphology and thermal transitions of self-assembled NIPAM-DMA copolymers in aqueous media depend on copolymer composition profileExternal link J. Colloid Interface Sci . 2024 , 662 , 99-108.
C. Ehle, A. Iyer-Bierhoff, Y. Wu, S. Xing, M. Kiehntopf, A. S. Mosig, M. Godmann, T. Heinzel Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase responseExternal link Commun. Biol. 2024 , 7 (1), 589.
C. Cerchia, L. Küfner, O. Werz, A. Lavecchia Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screeningExternal link Eur. J. Med. Chem . 2024 , 263 , 115932.
M. Behnke, C. T. Holick, A. Vollrath, S. Schubert, U. S. Schubert Knowledge-based design of multifunctional polymeric nanoparticlesExternal link Handb. Exp. Pharmacol . 2024 , 284 , 3-26.
J. De Breuck, M. Streiber, M. Ringleb, D. Schröder, N. Herzog, U. S. Schubert, S. Zechel, A. Traeger, M. N. LeiskeAmino-acid-derived anionic polyacrylamides with tailored hydrophobicity–physicochemical properties and cellular interactionsExternal link ACS Polym. 2024 , 4 (3), 222–234.
R. Kampes, A. Chettri, M. Sittig, G. Yang, S. Zechel, S. Kupfer, M. D. Hager, B. Dietzek-Ivanšić, U. S. SchubertAn iridium complex as bidentate halogen bond-based anion receptor featuring an increased optical responseExternal link Chem. Open 2024 , 13 , e202300183.
R. Pérez-Isidoro, A. G. Valdez-Lara, A. J. Díaz-Salazar, S. Hoeppener, C. Guerrero-Sánchez, P. Quintana-Owen, J. C. Ruiz-Suárez, U. S. Schubert, G. Ayora-Talavera, M. A. De Jesús-Téllez, E. Saldívar-GuerraBiophysical investigation of liposome systems decorated with bioconjugated copolymers in the presence of amantadineExternal link J. Mater. Chem . B 2024 , 12 , 5823–5837.
T. Schuett, P. Endres, J. Kimmig, R. Lorenz, Y. Köster, S. Stumpf, S. Zechel, U. S. SchubertAutomated screening of precipitation polymerizations and evaluation using image recognition for divinylbenzene and methacrylic acidExternal link J. Appl. Polym. Sci. 2024 , 141 (38), e55985.
L. Simon, L. S. Reichel, B. T. Benkhaled, J.-M. Devoisselle, S. Catrouillet, J. Eberhardt, S. Hoeppener, U. S. Schubert, J. C. Brendel, M. Morille, V. Lapinte, A. TraegerPolyoxazolines with cholesterol lipid anchor for fast intracellular deliveryExternal link Macromol. Biosci. 2024, 24 , 2400148.
J. Alex, C. Weber, C. Guerrero-Sanchez, U. S. SchubertRecent developments in synthetic approaches for macromolecular prodrugsExternal link Progr. Polym. Sci. 2024 , 155 , 101855.
E. Tsarenko, N. E. Goeppert, P. Dahlke, M. Behnke, G. Gangapurwala, B. Beringer-Siemers, L. Jaepel, C. Kellner, D. Pretzel, J. A. Czaplewska, A. Vollrath, P. M. Jordan, C. Weber, O. Werz, U. S. Schubert, I. NischangUnveiling the power of liquid chromatography in examining a library of degradable poly(2-oxazoline)s in nanomedicine applicationsExternal link J. Mater. Chem. B 2024 , 12 , 11926-11938.
R. Alonso-Roman, A. S. Mosig, M. T. Figge, K. Papenfort, C. Eggeling, F. H. Schacher, B. Hube, M. S. Gresnigt Organ-on-chip models for infectious disease researchExternal link Nat. Microbiol 2024 , 9 , 891-904.
I. Anufriev, J. Debbeler, A. Traeger, I. Nischang Analysis of Macromolecular Systems as Enabler for Energy and Life Science ApplicationsExternal link Macromol. Chem. Phys. 2024 , 225 , 17.
V. Bachmann, P. Schädel, J. Westhoff, M. Peric, F. Schömberg, A. L. Skaltsounis, S. Höppener, T. Pantsar, D. Fischer, I. Vilotijevic, O. Werzae Bromo-substituted indirubins for inhibition of protein kinase-mediated signalling involved in inflammatory mediator release in human monocyteExternal link s Bioorg. Chem. 2024 , 149 , 107470.
A. Chettri, L. I. Kaberov, N. Klosterhalfen, S. Perera, M. Jamshied, F. H. Schacher, B. Dietzek-Ivansic Poly(2-Oxazoline) amphiphilicity tunes the excited-state proton transfer of pyrenol-based polyphotoacidsExternal link s Chem. Eur. J. 2024 , 30 , e202401047.
A. Dasgupta, A. Koerfer, B. Kokot, I. Urbancic, C. Eggeling, P. Carravilla Effects and avoidance of photoconversion-induced artifacts in confocal and STED microscopyExternal link Nat. Methods 2024 , 21 , 1171–1174.
A. Feile, V. D. Wegner, M. Raasch, A. S. Mosig Immunocompetent intestine-on-chip model for analyzing gut mucosal immune responsesExternal link J. Vis. Exp. 2024 , 207 , e66603.
E. Gardey, J. Eberhardt, S. Hoeppener, F. H. Sobotta, J. C. Brendel, A. Stallmach Anti-inflammatory potential of beclometasone-loaded filomicelles on activated human monocytesExternal link Macromol. Biosci . 2024 , 24 , 2400179.
A. P. Grimm, M. Plank, A. Stihl, C. W. Schmitt, D. Voll, F. H. Schacher, J. Lahann, P. Théato Inverse vulcanization of activated norbornenyl esters-a versatile platform for functional sulfur polymersExternal link Angew. Chem. Int. Ed. 2024 , 63 , e202411010.
K. Günther, C. Ehrhardt, O. Werz, P. M. Jordan Protocol for lipid mediator profiling and phenotyping of human M1- and M2-monocyte-derived macrophages during host-pathogen interactionsExternal link STAR Protoc. 2024 , 5 (3), 103142.
C. Höppener, J. Aizpurua, H. Chen, S. Gräfe, A. Jorio, S. Kupfer, Z. L. Zhang, V. Deckert Tip-enhanced Raman scatteringExternal link Nat. Rev. Method. Prim. 2024 , 4 , 47.
L. J. Jia, K. González, T. Orasch, F. Schmidt, A. A. Brakhage Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunitiesExternal link Nat. Microbiol 2024 , 9 , 2216-2231.
R. Kampes, A. Chettri, M. Sittig, G. J. Yang, S. Zechel, S. Kupfer, M. D. Hager, B. Dietzek-Ivansic, U. S. Schubert An iridium complex as bidentate halogen bond-based anion receptor featuring an increasedoptical responseExternal link ChemistryOpen 2024 , 13 , e202300183.
Y. Köster, J. Kimmig, S. Zechel, U. S. Schubert Protocol for creating representations of molecular structures using a polymer-specific decoderExternal link STAR Protoc. 2024 , 5 (2), 103055.
S. Kröller, J. Schober, N. Krieg, S. Dennhardt, W. Pirschel, M. Kiehntopf, E. M. Conway, S. M. Coldewey The role of the n-terminal domain of thrombomodulin and the potential of recombinant human thrombomodulin as a therapeutic intervention for shiga toxin-induced hemolytic-uremic syndromeExternal link Toxins 2024 , 16 (9), 409.
N. Liu, M. Sonawane, O. Sommerfeld, C. M. Svensson, M. T. Figge, R. Bauer, S. J. Bischoff, M. Bauer, M. F. Osuchowski, A. T. Press Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis modelExternal link Front. Immunol. 2024 , 15 , 1432307.
K. Majzner, T. Deckert-Gaudig, M. Baranska, V. Deckert DOX-DNA interactions on the nanoscale: In situ studies using tip-enhanced raman scatteringExternal link Anal. Chem. 2024 , 96 (22), 8905-8913.
P. P. Mapfumo, L. S. Reichel, T. André, S. Hoeppener, L. K. Rudolph, A. Traeger Optimizing biocompatibility and gene delivery with DMAEA and DMAEAm: A niacin-derived copolymer approachExternal link Biomacromolecules 2024 , 25 (8), 4749-4761.
P. P. Mapfumo, L. S. Reichel, K. Leer, J. Egger, A. Dzierza, K. Peneva, D. Fischer, A. Traeger Harnessing guanidinium and imidazole functional groups: A dual-charged polymer strategy for enhanced gene deliveryExternal link ACS Macro Lett. 2024 , 13 (8), 1000-1007.
T. G. Maz, P. Dahlke, A. G. Ergül, A. Olgaç, P. M. Jordan, B. Çaliskan, O. Werz, E. Banoglu Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitorsExternal link Bioorg. Chem. 2024 , 147 , 107383.
R. Mincigrucci, E. Paltanin, J. S. Pelli-cresi, F. Gala, E. Pontecorvo, L. Foglia, D. De Angelis, D. Fainozzi, A. Gessini, D. S. P. Molina, O. Stranik, F. Wechsler, R. Heintzmann, J. Rothhardt, L. Loetgering, G. Ruocco, F. Bencivenga, C. Masciovecchio Structured illumination microscopy with extreme ultraviolet pulsesExternal link Opt. Express 2024 , 32 (17), 30813-30823.
R. H. D. Miora, M. Senftleben, S. Abrahamsson, E. Rohwer, R. Heintzman, G. Bosman Experimental validation of numerical point spread function calculation including aberration estimationExternal link Opt. Express 2024 , 32 (12), 21887-21908.
S. Schlicht, J. Campbell, A. Weber, J. Westhoff, D. Volodkin, D. Fischer, D. Drummer, A. Vikulina Vaterite-based in situ surface modification and process-dependent biocompatibility of laser sintered polypropyleneExternal link J. Mater. Res. Technol-JMRT 2024 , 32 , 3447-3455.
K. K. Schwickert, M. Glitscher, D. Bender, N. I. Benz, R. Murra, K. Schwickert, S. Pfalzgraf, T. Schirmeister, U. A. Hellmich, E. Hildt Zika virus replication is impaired by a selective agonist of the TRPML2 ion channelExternal link Antivir. Res. 2024 , 228 , 105940.
D. Shrestha, Y. Bahasoan, C. Eggeling Cellular output and physicochemical properties of the membrane-derived vesicles depend on chemical stimulantsExternal link ACS Appl. Mater. Interfaces. 2024 , 16 (37), 48982-48992.
H. F. Ulrich, F. V. Gruschwitz, T. Klein, N. Ziegenbalg, D. T. N. Anh, S. Fujii, S. Hoeppener, K. Sakurai, J. C. Brendel Influence of polymer side chain size and backbone length on the self-assembly of supramolecular polymer bottlebrushesExternal link Chem. Eur. J. 2024 , 30, 11.
K. Günther, V. Nischang, Z. Cseresnyés, T. Krüger, D. Sheta, Z. Abboud, T. Heinekamp, M. Werner, O. Kniemeyer, A. Beilhack, M. T. Figge, A. A. Brakhage, O. Werz, P. M. Jordan Aspergillus fumigatus-derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophagesExternal link Immunology 2024.
J. Plitzko, T. Köhler, T. Meyer-Zedler, S. Schubert, M. Schmitt, J. Popp Hydrolyzation-free characterization of acetalated dextran via 2D correlated raman spectroscopyExternal link J. Raman Spectrosc. 2024 .
C. Schultz, T. Wegner, C. Heusel, T. Gallagher, Y. Zheng, M. Werner, S. V. Wegner, T. Meyer-Zedler, O. Werz, M. Schmitt, J. Popp, F. Glorius Alkyne-tagged imidazolium-based membrane cholesterol analogs for Raman imaging applicationsExternal link Chem. Sci. 2024 , 15 , 14323-14335.
N. Engel, M. Dirauf, J. A. Czaplewska, I. Nischang, M. Gottschaldt, U. S. Schubert Determination of ω-end functionalities in tailored poly(2-alkyl-2-oxazoline)s by liquid chromatography and mass spectrometryExternal link R. Soc. Open Sci. 2024 , 11 , 231008.
N. t. Horst, J. Dietrich, T. Wilke Digitalchemlab ─digital and complexity-differentiated learning modules in an out of school student laboratoryExternal link J. Chem. Educ. 2024 , 101 (5), 1810–1821.
G. De Angelis, J. Abramo, M. Miasnikova, M. Taubert, C. Eggeling, F. Reina Homogeneous large field-of-view and compact iSCAT-TIRF setup for dynamic single molecule measurementsExternal link Opt. Express 2024 , 32 (26), 46607-46620.
A. G. Ergul, P. M. Jordan, P. Dahlke, N. B. Bal, A. Olgac, O. Uludag, O. Werz, B. Caliskan, E. BanogluNovel benzimidazole derivatives as potent inhibitors of microsomal prostaglandin E(2) synthase 1 for the potential treatment of inflammation, pain, and feverExternal link J. Med. Chem. 2024 , 67 (23), 21143-21162.
C. Haring, J. Schroeder, J. Jungwirth, B. Loffler, A. Henke, B. Engert, C. Ehrhardt ProcCluster® and procaine hydrochloride inhibit the replication of influenza A virus in vitroExternal link Front Microbiol 2024 , 15 , 1422651.
S. König, J. Schroeder, T. Heinekamp, A. A. Brakhage, B. Löffler, B. Engert, C. Ehrhardt ProcCluster® and procaine hydrochloride inhibit the growth of Aspergillus species and exert antimicrobial properties during coinfection with influenza A viruses and A. fumigatus in vitroExternal link Front. Cell. Infect. Microbiol. 2024 , 14 , 1445428.
A. Abou-Kandil, S. Tröger-Görler, A. Pschibul, T. Krüger, M. Rosin, F. Schmidt, P. Akbarimoghaddam, A. Sarkar, Z. Cseresnyés, Y. Shadkchan, T. Heinekamp, M. H. Gräler, A. E. Barber, G. Walther, M. T. Figge, A. A. Brakhage, N. Osherov, O. Kniemeyer The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistanceExternal link microLife 2024 , 6.
E. Dietel, T. WilkeSituationales Interesse an medizinischen Kontexten im Chemieunterricht: Pilotstudie, in Frühe naturwissenschaftliche Bildung (Ed.: H. van Vorst), GDCP,External link Essen, 2024 , pp. 770–773.
C. Visser, F. Rivieccio, T. Krüger, F. Schmidt, Z. Cseresnyés, M. Rohde, M. T. Figge, O. Kniemeyer, M. G. Blango, A. A. Brakhage Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatusExternal link microLife 2024 , 5.
J. E. Márquez-Castro, A. Licea-Claverie, C. Guerrero-Sánchez, E. R. MéndezSurface modification of gold nanorods (GNRDs) using double thermo-responsive block copolymers: Evaluation of self-assembly and stability of nanohybridsExternal link Polymers 2024 , 16 (23), 3293.
2023
E. Quansah, E. Gardey, A. Ramoji, T. Meyer-Zedler, B. Goehrig, A. Heutelbeck, S. Hoeppener, M. Schmitt, M. Waldner, A. Stallmach, J. PoppIntestinal epithelial barrier integrity investigated by label-free techniques in ulcerative colitis patientsExternal link Sci. Rep. 2023 , 13 , 2681.
D. FischerSustainability in drug and nanoparticle processingExternal link Springer Berlin Heidelberg, Berlin, Heidelberg, 2023 , 284 , 45-68.
I. Anufriev, S. Hoeppener, I. NischangPEG-Lipids: Quantitative study of unimers and aggregates thereof by the methods of molecular hydrodynamicsExternal link Anal. Chem. 2023 , 95 , 10795-10802.
L.-J. Jia, M. Rafiq, L. Radosa, P. Hortschansky, C. Cunha, Z. Cseresnyés, T. Krüger, F. Schmidt, T. Heinekamp, M. Straßburger, B. Löffler, T. Doenst, J. F. Lacerda, A. Campos, M. T. Figge, A. Carvalho, O. Kniemeyer, A. A. BrakhageAspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathwayExternal link Cell Host Microbe 2023 , 31 (3), 373-388.e310.
L. I. Kaberov, M. Sittig, A. Chettri, A. Ibrahim, B. Dietzek-Ivanšić, F. H. SchacherMulti-stimuli-responsive copolymers based on 1-pyrenol polyphotoacidsExternal link Polym. Chem. 2023 , 14 , 3453-3464.
H. Lindemann, M. Kühne, A. Koschella, M. Godmann, T. Heinzel, T. Heinze, "HDACi delivery systems based on cellulose valproate nanoparticles", in HDAC/HAT function assessment and inhibitor development: Methods and protocols (Ed.: O. H. Krämer)External link Springer US , 2023 , 195-205.
S. Wang, P. Poudel, F. H. Schacher, L. I. KaberovDouble stimuli-responsive azobenzene containing poly(2-oxazoline)s: synthesis, light, and temperature-responsive behaviorExternal link Polym. Chem. 2023 , 14 , 3381-3391.
F. Borner, S. Pace, P. M. Jordan, J. Gerstmeier, M. Gomez, A. Rossi, N. C. Gilbert, M. E. Newcomer, O. WerzAllosteric activation of 15-lipoxygenase-1 by boswellic acid Induces the lipid mediator class switch to promote resolution of inflammationExternal link Adv. Sci. 2023 , 10 , 2205604.
M. Behnke, P. Klemm, P. Dahlke, B. Shkodra, B. Beringer-Siemers, J. A. Czaplewska, S. Stumpf, P. M. Jordan, S. Schubert, S. Hoeppener, A. Vollrath, O. Werz, U. S. SchubertEthoxy acetalated dextran nanoparticles for drug delivery: A comparative study of formulation methodsExternal link Int. J. Pharma.: X 2023 , 5 , 100173.
M. Kühne, S. Hofmann, H. Lindemann, Z. Cseresnyés, A. Dzierza, D. Schröder, M. Godmann, A. Koschella, C. Eggeling, D. Fischer, M. T. Figge, T. Heinze, T. HeinzelAnalysis of HDACi-coupled nanoparticles: Opportunities and challenges.External link Methods Mol. Biol. 2023 , 2589 , 129-144.
T. Bellmann, J. Thamm, U. Beekmann, D. Kralisch, D. FischerIn situ formation of polymer microparticles in bacterial nanocellulose using alternative and sustainable solvents to incorporate lipophilic drugsExternal link Pharmaceutics 2023 , 15 , 559.
W. Foo, Z. Cseresnyes, C. Rossel, Y. F. Teng, A. Ramoji, M. Z. Chi, W. Hauswald, S. Huschke, S. Hoeppener, J. Popp, F. H. Schacher, M. Sierka, M. T. Figge, A. T. Press, M. BauerTuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cellsExternal link Biomaterials 2023 , 294 , 122016.
A. T. Frawley, K. G. Leslie, V. Wycisk, S. Galiani, D. Shrestha, C. Eggeling, H. L. AndersonA photoswitchable solvatochromic dye for probing membrane ordering by RESOLFT super-resolution microscopyExternal link ChemPhysChem 2023 , 24 , e202300125.
A. Fruntke, M. Behnke, L. M. Stafast, T. Trader, E. Dietel, A. Vollrath, C. Weber, U. S. Schubert, T. WilkeTargeted drug delivery: Synthesis of smart nanocarriers for school chemistry educationExternal link J. Chem. Educ. 2023 , 100 (2), 751-759.
S. Galiani, C. Eggeling, K. ReglinskiSuper-resolution microscopy and studies of peroxisomesExternal link Biol. Chem. 2023 , 404 , 87-106.
R. Gerst, Z. Cseresnyes, M. T. FiggeJIPipe: Visual batch processing for ImageJExternal link Nat. Meth. 2023 , 20 , 168-169.
M. Goldmann, F. Schmidt, Z. Cseresnyes, T. Orasch, S. Jahreis, S. Hartung, M. T. Figge, M. von Lilienfeld-Toal, T. Heinekamp, A. A. BrakhageThe lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatusExternal link mSphere 2023 , 8 , e00523-22.
K. Gonzalez, G. Gangapurwala, J. Alex, A. Vollrath, Z. Cseresnyes, C. Weber, J. A. Czaplewska, S. Hoeppener, C. M. Svensson, T. Orasch, T. Heinekamp, C. Guerrero-Sanchez, M. T. Figge, U. S. Schubert, A. A. BrakhageTargeting of phagolysosomes containing conidia of the fungus Aspergillus fumigatus with polymeric particlesExternal link Appl. Microbiol. Biotechnol. 2023 , 107 , 819-834.
F. Hausig-Punke, G. Dekevic, F. H. Sobotta, J. I. Solomun, F. Richter, D. Salzig, A. Traeger, J. C. BrendelEfficient transfection via an unexpected mechanism by near neutral polypiperazines with tailored response to endosomal pHExternal link Macromol. Biosci. 2023 , 23 , 2200517.
C. Hoppener, J. K. Elter, F. H. Schacher, V. DeckertInside block copolymer micelles-tracing interfacial influences on crosslinking efficiency in nanoscale confined spacesExternal link Small 2023 , 19 , 2206451.
V. Krauth, F. Bruno, S. Pace, P. M. Jordan, V. Temml, M. P. Romano, H. Khan, D. Schuster, A. Rossi, R. Filosa, O. WerzHighly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammationExternal link Biochem. Pharmacol. 2023 , 208 , 115385.
V. D. Lechuga-Islas, D. M. Sanchez-Cerrillo, S. Stumpf, R. Guerrero-Santos, U. S. Schubert, C. Guerrero-SanchezThermo-responsive polymer catalysts for polyester recycling processes: switching from homogeneous catalysis to heterogeneous separationsExternal link Polym. Chem. 2023 , 14 , 1893-1904.
V. D. Lechuga-Islas, M. Trejo-Maldonado, I. Anufriev, I. Nischang, I. Terzioglu, J. Ulbrich, R. Guerrero-Santos, L. E. Elizalde-Herrera, U. S. Schubert, C. Guerrero-SanchezAll-aqueous, surfactant-free, and pH-driven nanoformulation methods of dual-responsive polymer nanoparticles and their potential use as nanocarriers of pH-sensitive drugsExternal link Macromol. Biosci. 2023 , 23 , 2200262.
X. Liu, D. Wenisch, P. Dahlke, P. M. Jordan, M. A. Jakupec, C. R. Kowol, P. Liebing, O. Werz, B. K. Keppler, W. WeigandMulti-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDsExternal link Eur. J. Med. Chem. 2023 , 257 , 115515.
F. J. Ma, R. Kaufmann, J. Sedzicki, Z. Cseresnyes, C. Dehio, S. Hoeppener, M. T. Figge, R. HeintzmannGuided-deconvolution for correlative light and electron microscopyExternal link PLoS One 2023 , 18 , e0282803.
T. G. Maz, B. Koc, P. M. Jordan, K. Ibis, B. Caliskan, O. Werz, E. BanogluBenzoxazolone-5-urea derivatives as human soluble epoxide hydrolase (sEH) inhibitorsExternal link ACS Omega 2023 , 8 (2), 2445-2454.
M. Naumann, N. Arend, R. R. Guliev, C. Kretzer, I. Rubio, O. Werz, U. NeugebauerLabel-free characterization of macrophage polarization using raman spectroscopyExternal link Int. J. Mol. Sci. 2023 , 24 (1), 824.
T. Orasch, G. Gangapurwala, A. Vollrath, K. Gonzalez, J. Alex, A. D. Luis, C. Weber, S. Hoeppener, Z. Cseresnyes, M. T. Figge, C. Guerrero-Sanchez, U. S. Schubert, A. A. BrakhagePolymer-based particles against pathogenic fungi: A non-uptake delivery of compoundsExternal link Biomater. Adv. 2023 , 146 , 213300.
R. Perez-Isidoro, F. J. Guevara-Pantoja, C. Ventura-Hunter, C. Guerrero-Sanchez, J. C. Ruiz-Suarez, U. S. Schubert, E. Saldivar-GuerraFluidized or not fluidized? Biophysical characterization of biohybrid lipid/protein/polymer liposomes and their interaction with tetracaineExternal link Biochim. Et Biophys. Acta - General Subjects 2023 , 1867 (2), 130287.
M. Potenza, A. Giordano, M. G. Chini, A. Saviano, C. Kretzer, F. Raucci, M. Russo, G. Lauro, S. Terracciano, I. Bruno, M. Iorizzi, R. K. Hofstetter, S. Pace, F. Maione, O. Werz, G. BifulcoIdentification of 2-aminoacyl-1,3,4-thiadiazoles as prostaglandin E2 and leukotriene biosynthesis inhibitorsExternal link ACS Med. Chem. Lett. 2023 , 14 (1), 26-34.
L. M. Stafast, N. Engel, H. Gorls, C. Weber, U. S. SchubertEnd-functionalized diblock copolymers by mix and match of poly (2-oxazoline) and polyester building blocksExternal link Eur. Polym. J. 2023 , 184 , 111779.
E. Tsarenko, U. S. Schubert, I. NischangNanoparticle formulation composition analysis by liquid chromatography on reversed-phase monolithic silicaExternal link Anal. Chem. 2023 , 95 (2), 565-569.
S. Wang, P. Poudel, F. H. Schacher, L. I. KaberovStraightforward access to block and gradient light-responsive poly(2-oxazoline)s via cationic ring opening polymerization of 2-azobenzenyl-2-oxazolineExternal link Macromol. Rapid Commun. 2023 , 44 , 2300032.
T. Wloka, S. Czich, F. Chalupa-Gantner, M. Sittig, M. Dirauf, C. Weber, M. Gottschaldt, K. Liefeith, A. Ovsianikov, B. Dietzek-Ivanšić, U. S. SchubertNew water-soluble photo-initiators for two-photon polymerization based on benzylidene cyclopentanonesExternal link J. Photochem. Photobiol. A: Chem. 2023 , 442 , 114743.
T. X. Yang, A. Valavalkar, A. Romero-Arenas, A. Dasgupta, P. Then, A. Chettri, C. Eggeling, A. Ros, U. Pischel, B. Dietzek-IvansicExcited-state dynamics in borylated arylisoquinoline complexes in solution and in celluloExternal link Chem. Eur. J. 2023 , 29 , e202203468.
D. Zahn, J. Landers, M. Diegel, S. Salamon, A. Stihl, F. H. Schacher, H. Wende, J. Dellith, S. DutzOptimization of magnetic cobalt ferrite nanoparticles for magnetic heating applications in biomedical technologyExternal link Nanomaterials 2023 , 13 (10), 1673.
N. E. Göppert, A. Vollrath, L. M. Stafast, S. Stumpf, B. Schulze, S. Hoeppener, C. Weber, U. S. SchubertHow introduction of hydrolyzable moieties in pox influences particle formation – A Library approach based on block copolymers comprising polyestersExternal link RSC Appl. Polym. 2023 , 2 , 184-195.
Y. Köster, J. Kimmig, S. Zechel, U. S. SchubertFingerprint Applicable for Machine Learning Tested on LCST Behavior of PolymersExternal link Cell Reports Phys. Sci. 2023 , 4 (9), 101553.
J. M. Peschel, L. S. Reichel, T. Hoffmann, C. Enzensperger, U. S. Schubert, A. Traeger, M. GottschaldtModification of Branched Poly(ethylene imine) with Fructose for Selective Delivery of siRNA into Human Breast Cancer CellsExternal link Macromol. Bioscience 2023 , 23 , 2300135.
V. Ebrahimi, T. Stephan, J. Kim, P. Carravilla, C. Eggeling, S. Jakobs & K. Y. HanAuthor Correction: Deep learning enables fast, gentle STED microscopyExternal link Commun. Biol. 2023 , 6 , 831.
M. Ringleb, T. Schuett, S. Zechelab, U. S. SchubertBest practice for sampling in automated parallel synthesizersExternal link Digit. Discov. 2023 , 2 , 1883-1893.
Lukas K. Peltner, L. G., F. Boerner, N. C. Gilbert, O. Werz, P. M. Jordan, Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediatorsExternal link Cell Chem. Biol. 2023 , 30 (12), 1508 - 1524.e7.
V. Ebrahimi, T. Stephan, J. Kim, P. Carravilla, C. Eggeling, S. Jakobs, K. Y. Han Deep learning enables fast, gentle STED microscopyExternal link Commun. Biol . 2023 , 22 .
I. Urbančič, C. Eggeling, E. Sezgin Do lipids tune B cell signaling?External link Nat. Chem. Biol . 2023 , 19 , 669–670.
F. Behrendt, Z. Cseresnyés, R. Gerst, M. Gottschaldt, M. T. Figge, U. S. Schubert, Evaluation of reproducible cryogel preparation based on automated image analysis using deep learningExternal link J. Biomed. Mater. Res., Part A 2023 , 111 (11), 1734-1749.
N. E. Göppert, S. Quader, J. F. R. Van Guyse, C. Weber, K. Kataoka, U. S. Schubert Amphiphilic poly(2-oxazoline)s with glycine-containing hydrophobic blocks tailored for panobinostat- and imatinib-loaded micellesExternal link Biomacromolecules 2023, 24 (12), 5915-5925.
N. E. Göppert, A. Vollrath, L. M. Stafast, S. Stumpf, B. Schulze, S. Hoeppener, C. Weber, U. S. SchubertHow introduction of hydrolyzable moieties in POx influences particle formation – a library approach based on block copolymers comprising polyestersExternal link RSC Appl. Polym. 2023 , 2 , 184-195.
C. Neu, B. Wissuwa, C. Thiemermann, S. M. ColdeweyCardiovascular impairment in Shiga-toxin-2-induced experimental hemolytic–uremic syndrome: a pilot studyExternal link Front. Immunol. 2023 , 14 , 1252818.
H. Bae, M. Rodewald, T. Meyer-Zedler, T. W. Bocklitz, G. Matz, B. Messerschmidt, A. T. Press, M. Bauer, O. Guntinas-Lichius, A. Stallmach, M. Schmitt, J. Popp Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organsExternal link Sci. Rep. 2023 , 13 (1), 13779.
P. Dahlke, L. K. Peltner, P. M. Jordan, O. Werz Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediatorsExternal link Front. Pharmacol . 2023 , 14 , 1219160.
F. Dellbrügge, L. D. Jesse, A. Medyukhina, N. Liu, S. Neugebauer, M. Freißmuth, S. Höppener, M. T. Figge, H. Morrison, L. B. Riecken, A. T. PressContribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and diseaseExternal link Heliyon 2023 , 9 (11), e21009.
A. Fruntke, M. Behnke, E. Dietel, A. Vollrath, U. S. Schubert, T. Wilke Nanomedizin im Chemieunterricht: Zielgerichteter Wirkstofftransport mit polymeren NanopartikelnExternal link CHEMKON 2023, 31 (6), 207-214.
G. B. Garside, M. Sandoval, S. Beronja, K. L. Rudolph Lentiviral in situ targeting of stem cells in unperturbed intestinal epitheliumExternal link BMC Biol . 2023 , 21 (1), 6.
F. Guzmán-Lagunes, P. Wongsirichot, J. Winterburn, C. Guerrero Sanchez, C. Montiel Polyhydroxyalkanoates production: A challenge for the plastic industryExternal link Ind. Eng. Chem. Res. 2023 , 62 (44), 18133-18158.
C. Häring, J. Jungwirth, J. Schroeder, B. Löffler, B. Engert, C. Ehrhardt The local anaesthetic procaine prodrugs ProcCluster(®) and procaine hydrochloride impair SARS-CoV-2 replication and egress in vitroExternal link Int. J. Mol. Sci. 2023 , 24 (19), 14584.
R. Heintzmann, L. Loetgering, F. Wechsler Scalable angular spectrum propagationExternal link Optica 2023 , 10 (11), 1407-1416.
C. Höppener, J. K. Elter, F. H. Schacher, V. Deckert Inside block copolymer micelles—Tracing interfacial influences on crosslinking efficiency in nanoscale confined spacesExternal link Small 2023 , 19 (20), 2206451.
J. Hülsmann, H. Lindemann, J. Wegener, M. Kühne, M. Godmann, A. Koschella, S. M. Coldewey, T. Heinze, T. Heinzel Dually modified cellulose as a non-viral vector for the delivery and uptake of HDAC3 siRNAExternal link Pharmaceutics , 2023, 15 (12), 2659.
L. Klement, J. Drube The interplay of FLT3 and CXCR4 in acute myeloid leukemia: an ongoing debateExternal link Front. Oncol . 2023 , 13 , 1258679.
A. Koerfer, F. Reina, C. Eggeling Influence of different surface cleaning methods on STED-FCS and scanning STED-FCS calibration measurementsExternal link J. Microsc. 2023 , 296 , 150–153.
V. Nischang, F. M. Witt, F. Börner, M. Gomez, P. M. Jordan, O. Werz Frankincense preparation promotes formation of inflammation-resolving lipid mediators by manipulating lipoxygenases in human innate immune cellsExternal link Front. Pharmacol . 2023 , 14 , 1332628.
A. Olğaç, İ. Çapan, P. Dahlke, P. M. Jordan, O. Werz, E. Banoglu Substituted 1,2,4-triazoles as novel and selective inhibitors of leukotriene biosynthesis targeting 5-lipoxygenase-activating proteinExternal link Acs Omega 2023 , 8 (34), 31293-31304.
I. E. Osadare, L. Xiong, I. Rubio, U. Neugebauer, A. T. Press, A. Ramoji, J. Popp Raman Spectroscopy profiling of splenic t-cells in sepsis and endotoxemia in miceExternal link Int. J. Mol. Sci. 2023, 24 (15), 12027.
E. Quansah, T. A. Shaik, E. Çevik, X. Wang, C. Höppener, T. Meyer-Zedler, V. Deckert, M. Schmitt, J. Popp, C. Krafft Investigating biochemical and structural changes of glycated collagen using multimodal multiphoton imaging, Raman spectroscopy, and atomic force microscopyExternal link Anal. Bioanal. Chem . 2023 , 415 (25), 6257-6267.
Z. Rao, E. Brunner, B. Giszas, A. Iyer-Bierhoff, J. Gerstmeier, F. Börner, P. M. Jordan, S. Pace, K. P. L. Meyer, R. K. Hofstetter, D. Merk, C. Paulenz, T. Heinzel, P. C. Grunert, A. Stallmach, C. N. Serhan, M. Werner, O. Werz Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolutionExternal link Proc. Natl. Acad. Sci. U. S. A. 2023 , 120 (35), e2302070120.
C.-M. Svensson, K. Reglinski, W. Schliebs, R. Erdmann, C. Eggeling, M. T. Figge Quantitative analysis of peroxisome tracks using a Hidden Markov ModelExternal link Sci. Rep. 2023 , 13 (1), 19694.
A. Fruntke, N. Horst, C. Bley, B. Blümbott, M. Behnke, L. M. Stafast, A. Vollrath, U.S. Schubert, T. WilkeNanomedicine in chemistry education: development of a digital learning module with real life experimentsExternal link World J. Chem. Educ. 2023 , 11 , 97 – 103.
F. Behrendt, D. Pretzel, Z. Cseresnyés, M. Kleinsteuber, T. Wloka, L. Radosa, M. T. Figge, M. Gottschaldt, A. Brakhage, U. S. SchubertHydrophilic cryogels as potential 3D cell culture materials: Synthesis and characterization of 2-(methacrylamido) glucopyranose-based polymer scaffoldsExternal link J. Polym. Sci. 2023 , 61 , 3039-3054.
2022
V. D. Lechuga-Islas, C. Guerrero-Sanchez, R. Guerrero-Santos, J. Vitz, U. S. SchubertHigh-throughput/high-output experimentation in polymer researchExternal link in Macromolecular Engineering (Eds.: N. Hadjichristidis, Y. Gnanou, K. Matyjaszewski, M. Muthukumar), 2022 , pp. 1-26.
M. Trejo-Maldonado, A. Womiloju, S. Stumpf, S. Hoeppener, U. S. Schubert, L. E. Elizalde, C. Guerrero-SanchezTriazole-functionalized mesoporous materials based on poly(styrene-block-lactic acid): A morphology study of thin filmsExternal link Polymers 2022 , 14 , 2231.
P. Klemm, J. I. Solomun, M. Rodewald, M. T. Kuchenbrod, V. G. Hänsch, F. Richter, J. Popp, C. Hertweck, S. Hoeppener, C. Bonduelle, S. Lecommandoux, A. Traeger, S. SchubertEfficient gene delivery of tailored amphiphilic polypeptides by polyplex surfingExternal link Biomacromolecules 2022 , 23 , 4718-4733.
T. Schuett, M. Wejner, J. Kimmig, S. Zechel, T. Wilke, U. S. SchubertImprovement of high-throughput experimentation using synthesis robots by the implementation of tailor-made sensorsExternal link Polymers 2022 , 14 , 361.
A. Balestri, B. Lonetti, S. Harrisson, B. Farias-Mancilla, J. L. Zhang, H. Amenitsch, U. S. Schubert, C. Guerrero-Sanchez, C. Montis, D. BertiThermo-responsive lipophilic NIPAM-based block copolymers as stabilizers for lipid-based cubic nanoparticlesExternal link Colloid Surf. B-Biointerfaces 2022 , 220 , 9.
D. Beyer, J. Hoff, O. Sommerfeld, A. Zipprich, N. Gassler, A. T. PressThe liver in sepsis: molecular mechanism of liver failure and their potential for clinical translationExternal link Mol. Med. 2022 , 28 , 15.
I. Capan, P. M. Jordan, A. Olgac, B. Caliskan, C. Kretzer, O. Werz, E. BanogluDiscovery and optimization of piperazine urea derivatives as soluble epoxide hydrolase (sEH) inhibitorsExternal link ChemMedChem 2022 , 17 , 9.
M. Z. Chi, R. Gargouri, T. Schrader, K. Damak, R. Maalej, M. SierkaAtomistic descriptors for machine learning models of solubility parameters for small molecules and polymersExternal link Polymers 2022 , 14 , 11.
G. Cinar, J. I. Solomun, P. Mapfumo, A. Traeger, I. NischangNanoparticle sizing in the field of nanomedicine: Power of an analytical ultracentrifugeExternal link Anal. Chim. Acta 2022 , 1205 , 13.
A. Czapka, C. Grune, P. Schadel, V. Bachmann, K. Scheuer, M. Dirauf, C. Weber, A. L. Skaltsounis, K. D. Jandt, U. S. Schubert, D. Fischer, O. WerzDrug delivery of 6-bromoindirubin-3 '-glycerol-oxime ether employing poly(D,L-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solventsExternal link J. Nanobiotechnol. 2022 , 20 , 21.
A. De San Luis, M. Kleinsteuber, T. Schuett, S. Schubert, U. S. SchubertMiniemulsion polymerization at low temperature: A strategy for one-pot encapsulation of hydrophobic anti-inflammatory drugs into polyester-containing nanoparticlesExternal link J. Colloid Interface Sci. 2022 , 612 , 628-638.
N. Devi, C. Cokca, R. Sharma, M. Kumar, K. Peneva, R. K. Sharma, N. WangooFabrication of cell penetrating peptide labelled biodegradable poly (methacrylamide) nanoparticles for delivery of doxorubicin in HeLa cellsExternal link Mater. Today Commun. 2022 , 33 , 11.
M. Dirauf, I. Muljajew, C. Weber, U. S. SchubertRecent advances in degradable synthetic polymers for biomedical applications-Beyond polyestersExternal link Prog. Polym. Sci. 2022 , 129 , 40.
J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, J. Filor, V. Weitzel, A. Kliewer, E. Miess-Tanneberg, E. Kostenis, S. Schulz, C. HoffmannGPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulationExternal link Nat. Commun. 2022 , 13 , 18.
R. Eckenstaler, A. Ripperger, M. Hauke, M. Petermann, S. A. Hemkemeyer, E. Schwedhelm, S. Ergun, M. Frye, O. Werz, A. Koeberle, H. Braun, R. A. BenndorfA thromboxane A(2) receptor-driven COX-2-dependent feedback loop that affects endothelial homeostasis and angiogenesisExternal link Arterioscler. Thromb. Vasc. Biol. 2022 , 42 , 444-461.
A. G. Ergul, T. G. Maz, C. Kretzer, A. Olgac, P. M. Jordan, B. Caliskan, O. Werz, E. BanogluNovel potent benzimidazole-based microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C-4 synthaseExternal link Eur. J. Med. Chem. 2022 , 231 , 13.
W. Foo, A. Wiede, S. Bierwirth, R. Heintzmann, A. T. Press, W. HauswaldAutomated multicolor mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimensExternal link Biomed. Opt. Express 2022 , 13 , 3723-3742.
M. Gabel, A. Knauss, D. Fischer, M. F. Neurath, B. WeigmannSurface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using AntibodiesExternal link Int. J. Mol. Sci. 2022 , 23 , 22.
E. Gardey, F. H. Sobotta, S. Quickert, T. Bruns, J. C. Brendel, A. StallmachROS-sensitive polymer micelles for selective degradation in primary human monocytes from patients with active IBDExternal link Macromol. Biosci. 2022 , 22 , 6.
C. Grune, C. Kretzer, S. Zergiebel, S. Kattner, J. Thamm, S. Hoeppener, O. Werz, D. FischerEncapsulation of the anti-inflammatory dual FLAP/sEH inhibitor diflapolin improves the efficiency in human whole bloodExternal link J. Pharm. Sci. 2022 , 111 , 1843-1850.
F. Hausig-Punke, F. Richter, M. Hoernke, J. C. Brendel, A. TraegerTracking the endosomal escape: A closer look at calcein and related reportersExternal link Macromol. Biosci. 2022 , 22 , 26.
T. N. M. Hoang, Z. Cseresnyes, S. Hartung, M. Blickensdorf, C. Saffer, K. Rennert, A. S. Mosig, M. Von Lilienfeld-Toal, M. T. FiggeInvasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infectionExternal link Biomaterials 2022 , 283 , 14.
B. Hoffmann, R. Gerst, Z. Cseresnyes, W. Foo, O. Sommerfeld, A. T. Press, M. Bauer, M. T. FiggeSpatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT dataExternal link Photoacoustics 2022 , 26 , 12.
A. Jimenez-Victoria, R. D. Peralta-Rodriguez, E. Saldivar-Guerra, G. Y. Cortez-Mazatan, L. D. A. Soriano-Melgar, C. Guerrero-SanchezEmulsion polymerization using an amphiphilic oligoether ionic liquid as a surfactantExternal link Polymers 2022 , 14 , 19.
C. Kretzer, P. M. Jordan, R. Bilancia, A. Rossi, T. G. Maz, E. Banoglu, U. S. Schubert, O. WerzShifting the biosynthesis of leukotrienes toward specialized pro-resolving mediators by the 5-lipoxygenase-activating protein (FLAP) antagonist BRP-201External link J. Inflamm. Res. 2022 , 15 , 911-925.
H. Lindemann, T. HeinzeCellulose allylcarbamate with high content of reactive double bonds for thiol-ene reactionExternal link React. Funct. Polym. 2022 , 176 , 5.
N. Liu, M. Bauer, A. T. PressThe immunological function of CXCR2 in the liver during sepsisExternal link J. Inflamm. 2022 , 19 , 13.
L. Miek, P. M. Jordan, K. Gunther, S. Pace, T. Beyer, D. Kowalak, V. Hoerr, B. Loffler, L. Tuchscherr, C. N. Serhan, J. Gerstmeier, O. WerzStaphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acidExternal link Immunology 2022 , 166 , 47-67.
F. L. Portwich, Y. Carstensen, A. Dasgupta, S. Kupfer, R. Wyrwa, H. Gorls, C. Eggeling, B. Dietzek, S. Grafe, M. Wachtler, R. KretschmerA highly fluorescent dinuclear aluminium complex with near-unity quantum yieldExternal link Angew. Chem. Int. Ed. 2022 , 61 , 5.
M. Potenza, A. Giordano, M. G. Chini, A. Saviano, C. Kretzer, F. Raucci, M. Russo, G. Lauro, S. Terracciano, I. Bruno, M. Iorizzi, R. K. Hofstetter, S. Pace, F. Maione, O. Werz, G. BifulcoIdentification of 2-aminoacyl-1,3,4-thiadiazoles as prostaglandin E-2 and leukotriene biosynthesis inhibitorsExternal link ACS Med. Chem. Lett. 2022 , 14 , 26-34.
Z. G. Rao, D. Caprioglio, A. Gollowitzer, C. Kretzer, D. Imperio, J. A. Collado, L. Waltl, S. Lackner, G. Appendino, E. Munoz, V. Temml, O. Werz, A. Minassi, A. KoeberleRotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophagesExternal link Biochem. Pharmacol. 2022 , 203 , 16.
M. Reichel, V. Weitzel, L. Klement, C. Hoffmann, J. DrubeSuitability of GRK antibodies for individual detection and quantification of GRK isoforms in western blotsExternal link Int. J. Mol. Sci. 2022 , 23 , 1195.
I. Richter, S. Radosa, Z. Cseresnyes, I. Ferling, H. Buttner, S. P. Niehs, R. Gerst, K. Scherlach, M. T. Figge, F. Hillmann, C. HertweckToxin-producing endosymbionts shield pathogenic fungus against micropredatorsExternal link mBio 2022 , 13 , 16.
A. Saviano, S. De Vita, M. G. Chini, N. Marigliano, G. Lauro, G. M. Casillo, F. Raucci, M. Iorizzi, R. K. Hofstetter, K. Fischer, A. Koeberle, O. Werz, F. Maione, G. BifulcoIn silico, in vitro and in vivo analysis of tanshinone IIA and cryptotanshinone from salvia miltiorrhiza as modulators of cyclooxygenase-2/mPGES-1/endothelial prostaglandin EP3 pathwayExternal link Biomolecules 2022 , 12 , 26.
F. Siwczak, Z. Cseresnyes, M. I. A. Hassan, K. O. Aina, S. Carlstedt, A. Sigmund, M. Groger, B. G. J. Surewaard, O. Werz, M. T. Figge, L. Tuchscherr, B. Loffler, A. S. MosigHuman macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection modelExternal link Biomaterials 2022 , 287 , 12.
J. I. Solomun, L. Martin, P. Mapfumo, E. Moek, E. Amro, F. Becker, S. Tuempel, S. Hoeppener, K. L. Rudolph, A. TraegerpH-sensitive packaging of cationic particles by an anionic block copolymer shellExternal link J. Nanobiotechnol. 2022 , 20 , 17.
G. K. Soni, N. Wangoo, C. Cokca, K. Peneva, R. K. SharmaUltrasensitive aptasensor for arsenic detection using quantum dots and guanylated poly(methacrylamide)External link Anal. Chim. Acta 2022 , 1209 , 10.
L. M. Stafast, C. Weber, M. T. Kuchenbrod, S. Hoeppener, M. Behnke, S. Schubert, K. Mehmetaj, A. T. Press, M. Bauer, U. S. SchubertPoly(2-oxazoline) homopolymers and diblock copolymers containing retinoate omega-end groupsExternal link ACS Appl. Polym. Mater. 2022 , 4 , 3417-3425.
M. M. Suo, M. K. Rommelfanger, Y. L. Chen, E. M. Amro, B. Han, Z. Y. Chen, K. Szafranski, S. R. Chakkarappan, B. O. Boehm, A. L. MacLean, K. L. RudolphAge-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in miceExternal link Blood 2022 , 139 , 2653-2665.
I. Terzioglu, C. Ventura-Hunter, J. Ulbrich, E. Saldivar-Guerra, U. S. Schubert, C. Guerrero-SanchezAutomated parallel dialysis for purification of polymersExternal link Polymers 2022 , 14 , 12.
S. Turanli, A. G. Ergul, P. M. Jordan, A. Olgac, B. Caliskan, O. Werz, E. BanogluQuinazoline-4(3H)-one-7-carboxamide derivatives as human soluble epoxide hydrolase inhibitors with developable 5-lipoxygenase activating protein inhibitionExternal link ACS Omega 2022 , 7 , 36354–36365.
C. Ventura-Hunter, V. D. Lechuga-Islas, J. Ulbrich, C. Kellner, U. S. Schubert, E. Saldivar-Guerra, M. Rosales-Guzman, C. Guerrero-SanchezGlycerol methacrylate-based copolymers: Reactivity ratios, physicochemical characterization and cytotoxicityExternal link Eur. Polym. J. 2022 , 178 , 111478.
L. Vieider, E. Zoeller, E. Romp, M. Schoenthaler, V. Hernandez-Olmos, V. Temml, T. Hasenoehrl, D. Schuster, O. Werz, U. Garscha, B. MatuszczakSynthesis and structure-activity relationships for some novel diflapolin derivatives with benzimidazole subunitExternal link J. Enzym. Inhib. Med. Chem. 2022 , 37 , 1752-1764.
M. Wejner, T. WilkeLabPi: A digital measuring station for STEM education 4.0External link J. Chem. Educ. 2022 , 99 , 819-827.
X. B. Yao, C. Hoppener, H. Schneidewind, S. Hoeppener, Z. A. Tang, A. Buchholz, A. Konig, S. Mogavero, M. Diegel, J. Dellith, A. Turchanin, W. Plass, B. Hube, V. DeckertTargeted suppression of peptide degradation in Ag-based surface-enhanced Raman spectra by depletion of hot carriersExternal link Small 2022 , 18 , 2205080.
K. H. Zhang, P. M. Jordan, S. Pace, R. K. Hofstetter, M. Werner, X. C. Chen, O. WerzModulation of inflammation-related lipid mediator pathways by celastrol during human macrophage polarizationExternal link J. Inflamm. Res. 2022 , 15 , 3285-3304.
Z. Wallace, J. Kopycinski, H. Yang, M. L. McCully, C. Eggeling, J. Chojnacki, L. Dorrell Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapsesExternal link Sci. Rep. 2022 , (12), 13.
S. Insausti, M. Garcia-Porras, J. Torralba, I. Morillo, A. Ramos-Caballero, I. de la Arada, B. Apellaniz, J. M. M. Caaveiro, P. Carravilla, C. Eggeling, E. Rujas, J. L. Nieva Functional delineation of a protein–membrane interaction hotspot site on the HIV-1 neutralizing antibody 10E8External link Int. J. Mol. Sci. 2022 , 23 (18), 17.
S. Galiani, K. Reglinski, P. Carravilla, A. Barbotin, I. Urbancic, J. Ott, J. Sehr, E. Sezgin, F. Schneider, D. Waithe, P. Hublitz, W. Schliebs, R. Erdmann, C. Eggeling Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5External link Biophys. Rep . 2022 , (2), 15.
H. Lindemann, T. Heinze, Cellulose allylcarbamate with high content of reactive double bonds for thiol-ene reactionExternal link React. Funct. Polym . 2022 , 176, 105306.
N. E. Goppert, M. Dirauf, P. Liebing, C. Weber, U. S. SchubertOrganocatalyzed ring-opening polymerization of (S)-3-benzylmorpholine-2,5-dioneExternal link Macromol. Rapid Commun. 2022 , 44 , 6.
2021
C. Kretzer, B. Shkodra, P. Klemm, P. M. Jordan, D. Schröder, G. Cinar, A. Vollrath, S. Schubert, I. Nischang, S. Hoeppener, S. Stumpf, E. Banoglu, F. Gladigau, R. Bilancia, A. Rossi, C. Eggeling, U. Neugebauer, U. S. Schubert, O. WerzEthoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and bloodExternal link Cell. Mol. Life Sci. 2021 , 79 , 40.
A. M. Ali, M. Egiza, K. Murasawa, H. Sugita, T. Deckert-Gaudig, V. Deckert, T. YoshitakeEffects of substrate temperature and intermediate layer on adhesion, structural and mechanical properties of coaxial arc plasma deposition grown nanodiamond composite films on Si substratesExternal link Surf. Coat. Technol. 2021 , 417 , 127185.
T. T. V. Anh, A. Mostafa, Z. G. Rao, S. Pace, S. Schwaiger, C. Kretzer, V. Temml, C. Giesel, P. M. Jordan, R. Bilancia, C. Weinigel, S. Rummler, B. Waltenberger, T. Hung, A. Rossi, H. Stuppner, O. Werz, A. KoeberleFrom Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolutionExternal link Acta Pharmaceutica Sinica B 2021 , 11 , 1629-1647.
M. Brunzel, M. Dirauf, M. Sahn, J. A. Czaplewska, N. Fritz, C. Weber, I. Nischang, U. S. SchubertOn the identification and quantification of proton-initiated species in the synthesis of poly(2-alkyl-2-oxazoline)s by high resolution liquid chromatographyExternal link J. Chromatogr. A 2021 , 1653 , 462364.
H. Büttner, S. P. Niehs, K. Vandelannoote, Z. Cseresnyés, B. Dose, I. Richter, R. Gerst, M. T. Figge, T. P. Stinear, S. J. Pidot, C. HertweckBacterial endosymbionts protect beneficial soil fungus from nematode attackExternal link PNAS 2021 , 118 , e2110669118.
C. Chen, F. Richter, J. L. Zhang, C. Guerrero-Sanchez, A. Traeger, U. S. Schubert, A. C. Feng, S. H. ThangSynthesis of functional miktoarm star polymers in an automated parallel synthesizerExternal link Eur. Polym. J. 2021 , 160 , 110777.
Y. L. Chen, K. L. RudolphGranulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cellsExternal link Haematologica 2021 , 106 , 1516-1518.
C. Cokca, F. J. Hack, D. Costabel, K. Herwig, J. Hulsmann, P. Then, R. Heintzmann, D. Fischer, K. PenevaPEGylation of guanidinium and indole bearing poly(methacrylamide)s - Biocompatible terpolymers for pDNA deliveryExternal link Macromol. Biosci. 2021 , 21 , 2100146.
E. Y. Darussalam, O. Peterfi, T. Deckert-Gaudig, L. Roussille, V. DeckertpH-dependent disintegration of insulin amyloid fibrils monitored with atomic force microscopy and surface-enhanced Raman spectroscopyExternal link Spectrochim. Acta A Mol. Biomol. Spect. 2021 , 256 , 119672.
M. A. De Jesus-Tellez, S. De la Rosa-Garcia, I. Medrano-Galindo, I. Rosales-Penafiel, S. Gomez-Cornelio, C. Guerrero-Sanchez, U. S. Schubert, P. Quintana-OwenAntifungal properties of poly 2-(dimethylamino)ethyl methacrylate (PDMAEMA) and quaternized derivativesExternal link React. Funct. Polym. 2021 , 163 , 104887.
S. Deb, D. A. Felix, P. Koch, M. K. Deb, K. Szafranski, K. Buder, M. Sannai, M. Groth, J. Kirkpatrick, S. Pietsch, A. Gollowitzer, A. Gross, P. Riemenschneider, A. Koeberle, C. Gonzalez-Estevez, K. L. RudolphTnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasisExternal link EMBO Rep. 2021 , 22 , e49328.
S. Deinhardt-Emmer, S. Bottcher, C. Haring, L. Giebeler, A. Henke, R. Zell, J. Jungwirth, P. M. Jordan, O. Werz, F. Hornung, C. Brandt, M. Marquet, A. S. Mosig, M. W. Pletz, M. Schacke, J. Rodel, R. Heller, S. Nietzsche, B. Loffler, C. EhrhardtSARS-CoV-2 causes severe epithelial inflammation and barrier dysfunctionExternal link J. Virol. 2021 , 95 , e00110-21.
M. Dirauf, N. Fritz, M. Gottschaldt, C. Weber, U. S. SchubertPoly(2-ethyl-2-oxazoline) featuring a central amino moietyExternal link Macromol. Rapid Commun. 2021 , 42 , 2100132.
D. Fischer, N. Dusek, K. Hotzel, T. HeinzeThe role of formamidine groups in dextran based nonviral vectors for gene delivery on their physicochemical and biological characteristicsExternal link Macromol. Biosci. 2021 , 21 , 2000220.
L. Friedrich, G. Cingolani, Y. H. Ko, M. Iaselli, M. Miciaccia, M. G. Perrone, K. Neukirch, V. Bobinger, D. Merk, R. K. Hofstetter, O. Werz, A. Koeberle, A. Scilimati, G. SchneiderLearning from nature: From a marine natural product to synthetic cyclooxygenase-1 inhibitors by automated de novo designExternal link Adv. Sci. 2021 , 8 , 2100832.
A. N. Garcia-Sanchez, R. Yanez-Macias, J. L. Hernandez-Flores, A. Alvarez-Morales, J. H. Valenzuela-Soto, C. Guerrero-Sanchez, R. Guerrero-SantosExogenous application of polycationic nanobactericide on tomato plants reduces the candidatus liberibacter solanacearum infectionExternal link Plants 2021 , 10 , 2096.
N. C. Gilbert, M. E. Newcomer, O. WerzUntangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediatorsExternal link Biochem. Pharmacol. 2021 , 193 , 114759.
N. E. Göppert, M. Dirauf, C. Weber, U. S. SchubertBlock copolymers comprising degradable poly(2-ethyl-2-oxazoline) analogues via copper-free click chemistryExternal link Polym. Chem. 2021 , 12 , 5426–5437.
C. Grune, C. Zens, A. Czapka, K. Scheuer, J. Thamm, S. Hoeppener, K. D. Jandt, O. Werz, U. Neugebauer, D. FischerSustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticlesExternal link Int. J. Pharm. 2021 , 599 , 120404.
F. V. Gruschwitz, T. Klein, M. T. Kuchenbrod, N. Moriyama, S. Fujii, I. Nischang, S. Hoeppener, K. Sakurai, U. S. Schubert, J. C. BrendelKinetically controlling the length of self-assembled polymer nanofibers formed by intermolecular hydrogen bondsExternal link ACS Macro Lett. 2021 , 10 , 837-843.
T. Gürses, A. Olğaç, U. Garscha, T. Gür Maz, N. B. Bal, O. Uludağ, B. Çalışkan, U. S. Schubert, O. Werz, E. BanogluSimple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacyExternal link Bioorg. Chem. 2021 , 112 , 104861.
O. Gutierrez-Gutierrez, D. A. Felix, A. Salvetti, E. M. Amro, A. Thems, S. Pietsch, A. Koeberle, K. L. Rudolph, C. Gonzalez-EstevezRegeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein responseExternal link EMBO Rep. 2021 , 22 , e52905.
S. Hanio, J. Schlauersbach, B. Lenz, F. Spiegel, R. A. Böckmann, R. Schweins, I. Nischang, U. S. Schubert, S. Endres, A.-C. Pöppler, F. P. Brandl, T. M. Smit, K. Kolter, L. MeinelDrug-induced dynamics of bile colloidsExternal link Langmuir 2021 , 37 , 2543-2551.
M. I. A. Hassan, M. Keller, M. Hillger, U. Binder, S. Reuter, K. Herold, A. Telagathoti, H.-M. Dahse, S. Wicht, N. Trinks, S. Nietzsche, T. Deckert-Gaudig, V. Deckert, R. Mrowka, U. Terpitz, H. Peter Saluz, K. VoigtThe impact of episporic modification of Lichtheimia corymbifera on virulence and interaction with phagocytesExternal link Comput. Struct. Biotechnol. J. 2021 , 19 , 880-896.
F. Hausig, F. H. Sobotta, F. Richter, D. O. Harz, A. Traeger, J. C. BrendelCorrelation between protonation of tailor-made polypiperazines and endosomal escape for cytosolic protein deliveryExternal link ACS Appl. Mater. Interfaces 2021 , 13 , 35233-35247.
R. HeintzmannAnswers to fundamental questions in superresolution microscopyExternal link Philos. Trans. A Math. Phys. Eng. Sci. 2021 , 379.
P. M. Jordan, N. Andreas, M. Groth, P. Wegner, F. Weber, U. Jager, C. Kuchler, O. Werz, E. Serfling, T. Kamradt, A. Dudeck, S. DrubeATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoidsExternal link Immunology 2021 , 164 , 541-554.
P. M. Jordan, O. WerzSpecialized pro-resolving mediators: Biosynthesis and biological role in bacterial infectionsExternal link FEBS J. 2021 , DOI: 10.1111/febs.16266
T. Kammann, J. Hoff, I. Yildirim, B. Shkodra, T. Müller, C. Weber, M. H. Gräler, U. A. Maus, J. C. Paton, M. Singer, A. Traeger, U. S. Schubert, M. Bauer, A. T. PressIntracellularly released cholesterol from polymer-based delivery systems alters cellular responses to pneumolysin and promotes cell survivalExternal link Metabolites 2021 , 11 , 821.
J. Kimmig, T. Schuett, A. Vollrath, S. Zechel, U. S. SchubertPrediction of nanoparticle sizes for arbitrary methacrylates using artificial neuronal networksExternal link Adv. Sci. 2021 , 8 , 2102429.
J. Kimmig, S. Zechel, U. S. SchubertDigital transformation in materials science: A paradigm change in material's developmentExternal link Adv. Mater. 2021 , 33 , 2004940.
T. Klein, F. V. Gruschwitz, M. T. Kuchenbrod, I. Nischang, S. Hoeppener, J. C. BrendelAdjusting the length of supramolecular polymer bottlebrushes by top-down approachesExternal link Beilst. J. Org. Chem. 2021 , 17 , 2621-2628.
T. Klein, H. F. Ulrich, F. V. Gruschwitz, M. T. Kuchenbrod, R. Takahashi, S. Hoeppener, I. Nischang, K. Sakurai, J. C. BrendelOvercoming the necessity of a lateral aggregation in the formation of supramolecular polymer bottlebrushes in waterExternal link Macromol. Rapid Commun. 2021 , 42 , 2000585.
P. Klemm, M. Behnke, J. I. Solomun, C. Bonduelle, S. Lecommandoux, A. Traeger, S. SchubertSelf-assembled PEGylated amphiphilic polypeptides for gene transfectionExternal link J. Mater. Chem. B 2021 , 9 , 8149-8356.
S. Kluge, M. Schubert, L. Bormel, S. LorkowskiThe vitamin E long-chain metabolite alpha-13 '-COOH affects macrophage foam cell formation via modulation of the lipoprotein lipase systemExternal link Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 2021 , 1866 , 158875.
M. Kohler, P. Rinke, K. Fiederling, H. Gorls, N. Ueberschaar, F. H. Schacher, R. KretschmerCatalytic activity of various beta-diketiminate zinc complexes toward the ring-opening polymerization of caprolactone and derivativesExternal link Macromol. Chem. Phys. 2021 , 222 , 2100187.
B. Kokot, H. Kokot, P. Umek, K. P. van Midden, S. Pajk, M. Garvas, C. Eggeling, T. Koklic, I. Urbancic, J. StrancarHow to control fluorescent labeling of metal oxide nanoparticles for artefact-free live cell microscopyExternal link Nanotoxicology 2021 , 15 , 1102-1123.
M. Kuhne, C. Kretzer, H. Lindemann, M. Godmann, T. Heinze, O. Werz, T. HeinzelBiocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammationExternal link Int. J. Pharm. 2021 , 601 , 120567.
M. Kuhne, H. Lindemann, C. Grune, D. Schroder, Z. Cseresnyes, M. Godmann, A. Koschella, M. T. Figge, C. Eggeling, D. Fischer, T. Heinze, T. HeinzelBiocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activityExternal link J. Control. Release 2021 , 329 , 717-730.
V. D. Lechuga-Islas, M. Trejo-Maldonado, S. Stumpf, R. Guerrero-Santos, L. Elizalde-Herrera, U. S. Schubert, C. Guerrero-SanchezSeparation of volatile compounds from polymers by physisorptionExternal link Eur. Polym. J. 2021 , 159 , 110748.
K. Leer, G. Cinar, J. I. Solomun, L. Martin, I. Nischang, A. TraegerCore-crosslinked, temperature- and pH-responsive micelles: design, physicochemical characterization, and gene delivery applicationExternal link Nanoscale 2021 , 13 , 19412-19429.
B. Loffler, L. TuchscherrStaphylococcus aureus toxins: Promoter or handicap during infection?External link Toxins 2021 , 13 , 287.
I. Muljajew, M. Chi, A. Vollrath, C. Weber, B. Beringer-Siemers, S. Stumpf, S. Hoeppener, M. Sierka, U. S. SchubertA combined experimental and in silico approach to determine the compatibility of poly(ester amide)s and indomethacin in polymer nanoparticlesExternal link Eur. Polym. J. 2021 , 156 , 110606.
I. Muljajew, S. Huschke, A. Ramoji, Z. Cseresnyés, S. Hoeppener, I. Nischang, W. Foo, J. Popp, M. T. Figge, C. Weber, M. Bauer, U. S. Schubert, A. T. PressStealth effect of short polyoxazolines in graft copolymers: Minor changes of backbone end group determine liver cell-type specificityExternal link ACS Nano 2021 , 15 , 12298–12313
K. Neukirch, K. Alsabil, C. P. Dinh, R. Bilancia, M. Raasch, A. Ville, I. Cerqua, G. Viault, D. Breard, S. Pace, V. Temml, E. Brunner, P. M. Jordan, M. C. Marques, K. Loeser, A. Gollowitzer, S. Permann, J. Gerstmeier, S. Lorkowski, H. Stuppner, U. Garscha, T. Rodrigues, G. J. L. Bernardes, D. Schuster, D. Seraphin, P. Richomme, A. Rossi, A. S. Mosig, F. Roviezzo, O. Werz, J. J. Helesbeux, A. KoeberleExploration of long-chain vitamin E metabolites for the discovery of a highly potent, orally effective, and metabolically stable 5-LOX Inhibitor that limits inflammationExternal link J. Med. Chem. 2021 , 64 , 11496-11526.
M. F. Osuchowski, M. S. Winkler, T. Skirecki, S. Cajander, M. Shankar-Hari, G. Lachmann, G. Monneret, F. Venet, M. Bauer, F. M. Brunkhorst, S. Weis, A. Garcia-Salido, M. Kox, J.-M. Cavaillon, F. Uhle, M. A. Weigand, S. B. Flohé, W. J. Wiersinga, R. Almansa, A. de la Fuente, I. Martin-Loeches, C. Meisel, T. Spinetti, J. C. Schefold, C. Cilloniz, A. Torres, E. J. Giamarellos-Bourboulis, R. Ferrer, M. Girardis, A. Cossarizza, M. G. Netea, T. van der Poll, J. F. Bermejo-Martín, I. RubioThe COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entityExternal link The Lancet Respiratory Medicine 2021 , 9 , 622-642.
S. Pace, K. Zhang, P. M. Jordan, R. Bilancia, W. Wang, F. Börner, R. K. Hofstetter, M. Potenza, C. Kretzer, J. Gerstmeier, D. Fischer, S. Lorkowski, N. C. Gilbert, M. E. Newcomer, A. Rossi, X. Chen, O. WerzAnti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediatorsExternal link Pharmacol. Res. 2021 , 167 , 105556.
H. Penkert, A. Bertrand, V. Tiwari, S. Breimann, S. A. Muller, P. M. Jordan, M. J. Gerl, C. Klose, L. Cantuti-Castelvetri, M. Bosch-Queralt, I. Levental, S. F. Lichtenthaler, O. Werz, M. SimonsProteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recoveryExternal link Cell Reports 2021 , 37, 109898.
M. Potenza, M. Sciarretta, M. G. Chini, A. Saviano, F. Maione, M. V. D'Auria, S. De Marino, A. Giordano, R. K. Hofstetter, C. Festa, O. Werz, G. BifulcoStructure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathwaysExternal link Eur. J. Med. Chem. 2021 , 224 , 113693.
A. T. Press, P. Babic, B. Hoffmann, T. Müller, W. Foo, W. Hauswald, J. Benecke, M. Beretta, Z. Cseresnyés, S. Hoeppener, I. Nischang, S. M. Coldewey, M. H. Gräler, R. Bauer, F. Gonnert, N. Gaßler, R. Wetzker, M. T. Figge, U. S. Schubert, M. BauerTargeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsisExternal link EMBO Mol. Med. 2021 , 13 , e14436.
L. Pusch, R. Brox, K. Scheuer, T. Yokosawa, M. Wu, B. A. Zubiri, E. Spiecker, K. D. Jandt, D. Fischer, H. HacksteinDistinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporationExternal link Nanomedicine 2021 , 16 , 2075-2094.
F. Richter, K. Leer, L. Martin, P. Mapfumo, J. I. Solomun, M. T. Kuchenbrod, S. Hoeppener, J. C. Brendel, A. TraegerThe impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemmaExternal link J. Nanobiotechnol. 2021 , 19 , 292.
F. Richter, P. Mapfumo, L. Martin, J. I. Solomun, F. Hausig, J. J. Frietsch, T. Ernst, S. Hoeppener, J. C. Brendel, A. TraegerImproved gene delivery to K-562 leukemia cells by lipoic acid modified block copolymer micellesExternal link J. Nanobiotechnol. 2021 , 19 , 70.
T. Ritschel, K. Lehmann, M. Brunzel, J. Vitz, I. Nischang, U. S. Schubert, K. U. TotscheWell-defined poly(ethylene glycol) polymers as non-conventional reactive tracers of colloidal transport in porous mediaExternal link J. Colloid Interface Sci. 2021 , 584 , 592-601.
M. Rodewald, H. Bae, S. Huschke, T. Meyer-Zedler, M. Schmitt, A. T. Press, S. Schubert, M. Bauer, J. PoppIn vivo coherent anti-Stokes Raman scattering microscopy reveals vitamin A distribution in the liverExternal link J. Biophotonics 2021 , 14 , e202100040.
E. Rujas, D. P. Leaman, S. Insausti, P. Carravilla, M. Garcia-Porras, E. Largo, I. Morillo, R. Sanchez-Eugenia, L. Zhang, H. Cui, I. Iloro, F. Elortza, J. P. Julien, C. Eggeling, M. B. Zwick, J. M. M. Caaveiro, J. L. NievaFocal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profileExternal link Iscience 2021 , 24 , 102987.
P. Schädel, F. Troisi, A. Czapka, N. Gebert, S. Pace, A. Ori, O. WerzAging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in miceExternal link The FASEB Journal 2021 , 35 , e21558.
F. Schneider, T. Sych, C. Eggeling, E. SezginInfluence of nanobody binding on fluorescence emission, mobility, and organization of GFP-tagged proteinsExternal link Iscience 2021 , 24 , 101891.
M. Sittig, J. C. Tom, J. K. Elter, F. H. Schacher, B. DietzekQuinoline photobasicity: Investigation within water-soluble light-responsive copolymersExternal link Chem. Eur. J. 2021 , 27 , 1072-1079.
F. H. Sobotta, M. T. Kuchenbrod, C. Grune, D. Fischer, S. Hoeppener, J. C. BrendelElucidating preparation-structure relationships for the morphology evolution during the RAFT dispersion polymerization of N-acryloyl thiomorpholineExternal link Polym. Chem. 2021 , 12 , 1668-1680.
F. H. Sobotta, M. T. Kuchenbrod, F. V. Gruschwitz, G. Festag, P. Bellstedt, S. Hoeppener, J. C. BrendelTuneable time delay in the burst release from oxidation-sensitive polymersomes made by PISAExternal link Angew. Chem. Int. Ed. 2021 , 60 , 24716-24723.
O. Sommerfeld, A. Medyukhina, S. Neugebauer, M. Ghait, S. Ulferts, A. Lupp, R. König, R. Wetzker, S. Schulz, M. T. Figge, M. Bauer, A. T. PressTargeting complement C5a receptor 1 for the treatment of immunosuppression in sepsisExternal link Mol. Ther. 2021 , 29 , 338-346.
F. A. Stanford, N. Matthies, Z. Cseresnyés, M. T. Figge, M. I. A. Hassan, K. VoigtExpression patterns in reductive iron assimilation and functional consequences during phagocytosis of Lichtheimia corymbifera, an emerging cause of mucormycosisExternal link Journal of Fungi 2021 , 7 , 272.
B. H. Stumpf, P. Nowakowski, C. Eggeling, A. Maciolek, A. S. SmithProtein induced lipid demixing in homogeneous membranesExternal link Phys. Rev. Res. 2021 , 3 , L042013.
A. Tannert, J. G. Lopez, N. Petkov, A. Ivanova, K. Peneva, U. NeugebauerLysosome-targeting pH indicator based on peri-fused naphthalene monoimide with superior stability for long term live cell imagingExternal link J. Mater. Chem. B 2021 , 9 , 112-124.
I. Urbancic, L. Schiffelers, E. Jenkins, W. J. Gong, A. M. Santos, F. Schneider, C. O'Brien-Ball, M. T. Vuong, N. Ashman, E. Sezgin, C. EggelingAggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cellsExternal link FEBS Lett. 2021 , 595 , 2127-2146.
A. Vollrath, C. Kretzer, B. Beringer-Siemers, B. Shkodra, J. A. Czaplewska, D. Bandelli, S. Stumpf, S. Hoeppener, C. Weber, O. Werz, U. S. SchubertEffect of crystallinity on the properties of polycaprolactone nanoparticles containing the dual FLAP/mPEGS-1 inhibitor BRP-187External link Polymers 2021 , 13 , 2557.
L. Wang, U. S. Schubert, S. HoeppenerSurface chemical reactions on self-assembled silane based monolayersExternal link Chem. Soc. Rev. 2021 , 50 , 6507-6540.
L. Wang, A. A. Womiloju, C. Höppener, U. S. Schubert, S. HoeppenerOn the stability of microwave-fabricated SERS substrates – chemical and morphological considerationsExternal link Beilst. J. Nanotechnol. 2021 , 12 , 541-551.
S. Willems, L. Gellrich, A. Chaikuad, S. Kluge, O. Werz, J. Heering, S. Knapp, S. Lorkowski, M. Schubert-Zsilavecz, D. MerkEndogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactionsExternal link Cell Chem. Biol. 2021 , 28 , 1489-1500.
K. Zhang, S. Pace, P. M. Jordan, L. K. Peltner, A. Weber, D. Fischer, R. K. Hofstetter, X. Chen, O. WerzBeneficial modulation of lipid mediator biosynthesis in innate immune cells by antirheumatic tripterygium wilfordii glycosidesExternal link Biomolecules 2021 , 11 , 746.
J. Alex, J. Ulbrich, M. Rosales-Guzmán, C. Weber, U. S. Schubert, C. Guerrero-SanchezKinetic investigations on homo- and co-polymerizations of pentafluorophenyl (meth)acrylatesExternal link Eur. Polym. J. 2021 , 143 , 110175.
F. Becker, K. L. RudolphTargeting enzyme agingExternal link Science 2021 , DOI: 10.1126/science.abf9566.
C. Grune, J. Thamm, O. Werz, D. FischerCyrene™ as an alternative sustainable solvent for the preparation of poly(lactic-co-glycolic acid) nanoparticlesExternal link J. Pharm. Sci. 2021 , 110 , 959-964.
P. Klemm, S. Huschke, M. Rodewald, N. Ehteshamzad, M. Behnke, X. Wang, G. Cinar, I. Nischang, S. Hoeppener, C. Weber, A. Press, C. Höppener, T. Meyer, V. K. Deckert, M. Schmitt, J. Popp, M. Bauer, S. SchubertCharacterization of a library of vitamin A-functionalized polymethacrylate-based nanoparticles for siRNA deliveryExternal link Polym. Chem. 2021 , DOI: 10.1039/D1030PY01626H.
K. L. RudolphStem cell agingExternal link Mech. Ageing Dev. 2021 , 193 , 111394.
J. I. Solomun, G. Cinar, P. Mapfumo, F. Richter, E. Moek, F. Hausig, L. Martin, S. Hoeppener, I. Nischang, A. TraegerSolely aqueous formulation of hydrophobic cationic polymers for efficient gene deliveryExternal link Int. J. Pharm. 2021 , 593 , 120080.
C. St Thomas, L. E. Elizalde, E. J. Regalado, M. A. De Jesús-Téllez, G. Festag, U. S. Schubert, C. Guerrero-SánchezUnderstanding the influence of chemical structure and length of hydrophobic blocks on the rheological properties of associative copolymersExternal link Eur. Polym. J. 2021 , 143 , 110190.
H. Wang, R. Heintzmann, B. Diederich The power in your pocket – uncover smartphones for use as cutting-edge microscopic instruments in science and researchExternal link Adv. Opt. Techn . 2021 , 10 (2), 89-108.
C. Guerrero-Sanchez, R. Yañez-Macias, M. Rosales-Guzmán, M. A. De Jesus-Tellez, C. Piñon-Balderrama, J. J. Haven, G. Moad, T. Junkers, U. S. Schubert High-throughput/high-output experimentation in RAFT POLYMER synthesisExternal link In RAFT Polymerization , 2021 ; pp 1051-1076.
P. Carravilla, A. Dasgupta, G. Zhurgenbayeva, D. I. Danylchuk, A. S. Klymchenko, E. Sezgin, C. EggelingLong-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyesExternal link Biophys. Rep . 2021 , 1 (2), 100023
2020
M. Behnke, A. Vollrath, L. Klepsch, B. Beringer-Siemers, S. Stumpf, J. A. A. Czaplewska, S. Hoeppener, O. Werz, U. S. SchubertOptimized encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-stabilized PLGA nanoparticles using microfluidicsExternal link Polymers 2020 , 12 , 2751.
S. Deb, D. A. Felix, P. Koch, M. K. Deb, K. Szafranski, K. Buder, M. Sannai, M. Groth, J. Kirkpatrick, S. Pietsch, A. Gollowitzer, A. Groß, P. Riemenschneider, A. Koeberle, C. Gonzalez-Estevez, K. L. RudolphTnfaip2/Exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasisExternal link EMBO Rep. 2020 , DOI: 10.15252/embr.201949328.
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B. Farias-Mancilla, J. Zhang, I. Kulai, M. Destarac, U. S. Schubert, C. Guerrero Sanchez, S. Harrisson, O. ColombaniGradient and asymmetric copolymers: The role of the copolymer composition profile in the ionization of weak polyelectrolytesExternal link Polym. Chem. 2020 , DOI: 10.1039/d1030py01059f.
N. E. Goeppert, M. Kleinsteuber, C. Weber, U. S. SchubertDegradable poly(2-oxazoline) analogues from partially oxidized poly(ethylene imine)External link Macromolecules 2020 , 53 , 10837-10846.
F. J. Hack, C. Cokca, S. Städter, J. Hülsmann, K. Peneva, D. FischerIndole, phenyl and phenol groups - the role of the comonomer on gene delivery in guanidinium containing methacrylamide terpolymersExternal link Macromol. Rapid Commun. 2020 , 2000580.
C. Helbing, K. D. Jandt Novel protein and peptide nanofibrous structures via supramolecular co-assemblyExternal link in Artificial Protein and Peptide Nanofibers (Eds.: G. Wei, S. G. Kumbar), Woodhead Publishing, 2020 , pp. 69-97.
T. Klein, H. F. Ulrich, F. V. Gruschwitz, M. T. Kuchenbrod, R. Takahashi, S. Fujii, S. Hoeppener, I. Nischang, K. Sakurai, J. C. BrendelImpact of amino acids on the aqueous self-assembly of benzenetrispeptides into supramolecular polymer bottlebrushesExternal link Polym. Chem. 2020 , 11 , 6763-6771.
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M. T. Kuchenbrod, R. Heintzmann, U. S. Schubert, S. HoeppenerRevisiting staining of biological samples for electron microscopy: Perspectives for recent researchExternal link Mater. Horiz. 2020 , DOI: 10.1039/D1030MH01579B.
J. J. Lühr, N. Alex, L. Amon, M. Kräter, M. Kubánková, E. Sezgin, C. H. K. Lehmann, L. Heger, G. F. Heidkamp, A.-S. Smith, V. Zaburdaev, R. A. Böckmann, I. Levental, M. L. Dustin, C. Eggeling, J. Guck, D. DudziakMaturation of monocyte-derived DCs leads to increased cellular stiffness, higher membrane fluidity, and changed lipid compositionExternal link Front. Immunol. 2020 , 11 , 590121.
B. Shkodra, A. T. Press, A. Vollrath, I. Nischang, S. Schubert, S. Hoeppener, D. Haas, C. Enzensperger, M. Lehmann, P. Babic, K. J. Benecke, A. Traeger, M. Bauer, U. S. SchubertFormulation of liver-specific PLGA-DY-635 nanoparticles loaded with the protein kinase C inhibitor bisindolylmaleimide IExternal link Pharmaceutics 2020 , 12 , 1110.
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M. A. Ali, M. Egiza, K. Murasawa, H. Sugita, T. Deckert-gaudig, V. Deckert, T. YoshitakeInfluence of adhesion intermediate layers on the stability of nanodiamond composite films deposited on Si substrates by coaxial arc plasmaExternal link Appl. Phys. Exp. 2020 , DOI: 10.35848/31882-30786/ab35891d35841.
A. J. Beer, D. Hertz, E. Seemann, M. Beretta, M. Westermann, R. Bauer, M. Bauer, M. M. Kessels, B. QualmannReduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsisExternal link Sci. Rep. 2020 , 10 , 13110.
S. Czich, T. Wloka, H. Rothe, J. Rost, F. Penzold, M. Kleinsteuber, M. Gottschaldt, U. S. Schubert, K. LiefeithTwo-photon polymerized poly(2-ethyl-2-oxazoline) hydrogel 3D microstructures with tunable mechanical properties for tissue engineeringExternal link Molecules 2020 , 25 , 5066.
A. Dorosz, M. Grosicki, J. Dybas, E. Matuszyk, M. Rodewald, T. Meyer, J. Popp, K. Malek, M. BaranskaEosinophils and neutrophils—Molecular differences revealed by spontaneous Raman, CARS and fluorescence microscopyExternal link Cells 2020 , 9 , 2041.
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A. T. Frawley, V. Wycisk, Y. Xiong, S. Galiani, E. Sezgin, I. Urbančič, A. Vargas Jentzsch, K. G. Leslie, C. Eggeling, H. L. AndersonSuper-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyadExternal link Chem. Sci. 2020 , 11 , 8955-8960.
N. Gebert, C.-W. Cheng, J. M. Kirkpatrick, D. Di Fraia, J. Yun, P. Schädel, S. Pace, G. B. Garside, O. Werz, K. L. Rudolph, H. Jasper, Ö. H. Yilmaz, A. OriRegion-specific proteome changes of the intestinal epithelium during aging and dietary restrictionExternal link Cell Rep. 2020 , 31 , 107565.
N. C. Gilbert, J. Gerstmeier, E. E. Schexnaydre, F. Börner, U. Garscha, D. B. Neau, O. Werz, M. E. NewcomerStructural and mechanistic insights into 5-lipoxygenase inhibition by natural productsExternal link Nat. Chem. Biol. 2020 , 16 , 783-790.
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K. D. Jandt, D. C. WattsNanotechnology in dentistry: Present and future perspectives on dental nanomaterialsExternal link Dent. Mater. 2020 , 36 , 1365-1378.
Y. Li, J. C. Tom, P. Biehl, J. Ling, F. H. SchacherBlock polypeptoids: Synthesis, characterization, and response toward irradiation with UV light and temperatureExternal link Macromolecules 2020 , 53 , 5218-5226.
J. B. Max, K. Kowalczuk, M. Köhler, C. Neumann, F. Pielenz, L. V. Sigolaeva, D. V. Pergushov, A. Turchanin, F. Langenhorst, F. H. SchacherPolyampholytic poly(dehydroalanine) graft copolymers as smart templates for pH-controlled formation of alloy nanoparticlesExternal link Macromolecules 2020 , 53 , 4511-4523.
K. Reglinski, L. Steinfort-Effelsberg, E. Sezgin, C. Klose, H. W. Platta, W. Girzalsky, C. Eggeling, R. ErdmannFluidity and lipid composition of membranes of peroxisomes, mitochondria and the ER from oleic acid-induced Saccharomyces cerevisiaeExternal link Front. Cell Dev. Biol. 2020 , 8 , 574363.
E. Rujas, S. Insausti, D. P. Leaman, P. Carravilla, S. González-Resines, V. Monceaux, R. Sánchez-Eugenia, M. García-Porras, I. Iloro, L. Zhang, F. Elortza, J.-P. Julien, A. Saéz-Cirión, M. B. Zwick, C. Eggeling, A. Ojida, C. Domene, J. M. M. Caaveiro, J. L. NievaAffinity for the Interface Underpins Potency of Antibodies Operating In Membrane EnvironmentsExternal link Cell Rep. 2020 , 32 , 108037.
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O. Sommerfeld, A. Medyukhina, S. Neugebauer, M. Ghait, S. Ulferts, A. Lupp, R. König, R. Wetzker, S. Schulz, M. T. Figge, M. Bauer, A. T. PressTargeting complement C5a Receptor 1 for the treatment of immunosuppression in sepsisExternal link Mol. Ther. 2020 , DOI: 10.1016/j.ymthe.2020.1009.1008.
R. Takahashi, S. Miwa, C. Rössel, S. Fujii, J. H. Lee, F. H. Schacher, K. SakuraiPolymersome formation induced by encapsulation of water-insoluble molecules within ABC triblock terpolymersExternal link Polym. Chem. 2020 , 11 , 3446-3452.
J. Torralba, I. de la Arada, P. Carravilla, S. Insausti, E. Rujas, E. Largo, C. Eggeling, J. L. R. Arrondo, B. Apellániz, J. L. NievaCholesterol constrains the antigenic configuration of the membrane-proximal neutralizing HIV-1 epitopeExternal link ACS Infect. Dis. 2020 , 6 , 2155-2168.
D. Waithe, J. M. Brown, K. Reglinski, I. Diez-Sevilla, D. Roberts, C. EggelingObject detection networks and augmented reality for cellular detection in fluorescence microscopyExternal link J. Cell Biol. 2020 , 219 , e201903166.
M. Wallert, L. Börmel, S. LorkowskiInflammatory diseases and vitamin E—What do we know and where do we go?External link Mol. Nutr. Food Res. 2020 , 2000097.
N. Arend, A. Pittner, A. Ramoji, A. S. Mondol, M. Dahms, J. Rüger, O. Kurzai, I. W. Schie, M. Bauer, J. Popp, U. NeugebauerDetection and differentiation of bacterial and fungal infection of neutrophils from peripheral blood using raman spectroscopyExternal link Anal. Chem. 2020 , 92 , 10560-10568.
G. Cinar, C. Englert, U. S. Schubert, I. NischangSalient features of medical nanoparticles in biological fluids from an analytical ultracentrifugeExternal link Nanoscale 2020 , DOI: 10.1039/D1030NR06153K.
A. Czapka, S. König, C. Pergola, C. Grune, K. Vougogiannopoulou, A.-L. Skaltsounis, D. Fischer, O. WerzThe indirubin derivative 6-bromoindirubin-3’-glycerol-oxime ether (6BIGOE) potently modulates inflammatory cytokine and prostaglandin release from human monocytes through GSK-3 interferenceExternal link Biochem. Pharmacol. 2020 , 180 , 114170.
C. P. Dinh, A. Ville, K. Neukirch, G. Viault, V. Temml, A. Koeberle, O. Werz, D. Schuster, H. Stuppner, P. Richomme, J.-J. Helesbeux, D. SéraphinStructure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitorsExternal link Eur. J. Med. Chem. 2020 , 202 , 112518.
P. Ernst, A. T. Press, M. Fischer, V. Günther, C. Gräfe, J. H. Clement, T. Ernst, U. S. Schubert, J. Wotschadlo, M. Lehmann, C. Enzensperger, M. Bauer, A. HochhausPolymethine dye-functionalized nanoparticles for targeting CML stem cellsExternal link Mol. Ther. Oncolytics 2020 , 18 , 372-381.
T. Götz, M. Dahms, J. Kirchhoff, C. Beleites, U. Glaser, J. A. Bohnert, M. W. Pletz, J. Popp, P. Schlattmann, U. NeugebauerAutomated and rapid identification of multidrug resistant Escherichia coli against the lead drugs of acylureidopenicillins, cephalosporins, and fluoroquinolones using specific Raman marker bandsExternal link J. Biophotonics 2020 , 13 , e202000149.
M. Grube, V. Dinu, H. Lindemann, F. Pielenz, G. Festag, U. S. Schubert, T. Heinze, S. Harding, I. NischangPolysaccharide valproates: Structure - property relationships in solutionExternal link Carbohydr. Polym. 2020 , 246 , 116652.
E. Jäger, S. Murthy, C. Schmidt, M. Hahn, S. Strobel, A. Peters, C. Stäubert, P. Sungur, T. Venus, M. Geisler, V. Radusheva, S. Raps, K. Rothe, R. Scholz, S. Jung, S. Wagner, M. Pierer, O. Seifert, W. Chang, I. Estrela-Lopis, N. Raulien, K. Krohn, N. Sträter, S. Hoeppener, T. Schöneberg, M. Rossol, U. WagnerCalcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritisExternal link Nat. Commun. 2020 , 11 , 4243.
P. M. Jordan, J. Gerstmeier, S. Pace, R. Bilancia, Z. Rao, F. Börner, L. Miek, Ó. Gutiérrez-Gutiérrez, V. Arakandy, A. Rossi, A. Ialenti, C. González-Estévez, B. Löffler, L. Tuchscherr, C. N. Serhan, O. WerzStaphylococcus aureus-derived α-hemolysin evokes generation of specialized pro-resolving mediators promoting inflammation resolutionExternal link Cell Reports 2020 , 33 , 108247.
M. Kühne, H. Lindemann, C. Grune, D. Schröder, Z. Cseresnyés, M. Godmann, A. Koschella, M. T. Figge, C. Eggeling, D. Fischer, T. Heinze, T. HeinzelBiocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activityExternal link J. Control. Release 2020 , DOI: 10.1016/j.jconrel.2020.1010.1006.
A. Lezov, A. Gubarev, T. Kaiser, W. Tobaschus, N. Tsvetkov, I. Nischang, U. S. Schubert, H. Frey, I. Perevyazko“Hard” sphere behavior of “soft”, globular-like, hyperbranched polyglycerols – Extensive molecular hydrodynamic and light scattering studiesExternal link Macromolecules 2020 , DOI: 10.1021/acs.macromol.1020c01340.
S. Pace, O. WerzImpact of androgens on inflammation-related lipid mediator biosynthesis in innate immune cellsExternal link Front. Immunol. 2020 , 11 , DOI: 10.3389/fimmu.2020.01356.
S. Rahimi, S. Stumpf, O. Grimm, F. H. Schacher, U. S. Schubert, S. SchubertDual photo- and pH-responsive spirooxazine-functionalized dextran nanoparticlesExternal link Biomacromolecules 2020 , 21 , 3620-3630.
T. Ritschel, K. Lehmann, M. Brunzel, J. Vitz, I. Nischang, U. S. Schubert, K. U. TotscheWell-defined poly(ethylene glycol) polymers as non-conventional reactive tracers of colloidal transport in porous mediaExternal link J. Colloid Interface Sci. 2020 , DOI: 10.1016/j.jcis.2020.1009.1056.
K. Scheuer, D. Bandelli, C. Helbing, C. Weber, J. Alex, J. B. Max, A. Hocken, O. Stranik, L. Seiler, F. Gladigau, U. Neugebauer, F. H. Schacher, U. S. Schubert, K. D. JandtSelf-assembly of copolyesters into stereocomplex crystallites tunes the properties of polyester nanoparticlesExternal link Macromolecules 2020 , 53 , 8340-8351.
F. Schmidt, A. Thywißen, M. Goldmann, C. Cunha, Z. Cseresnyés, H. Schmidt, M. Rafiq, S. Galiani, M. H. Gräler, G. Chamilos, J. F. Lacerda, A. Campos, C. Eggeling, M. T. Figge, T. Heinekamp, S. G. Filler, A. Carvalho, A. A. BrakhageFlotillin-dependent membrane microdomains are required for functional phagolysosomes against fungal infectionsExternal link Cell Reports 2020 , 32 , 108017.
T. Schuett, J. Kimmig, S. Zechel, U. S. SchubertAutomated polymer purification using dialysisExternal link Polymers 2020 , 12 , 2095.
M. Sittig, J. C. Tom, J. Elter, F. H. Schacher, B. DietzekQuinoline photobasicity – Investigation within water-soluble light-responsive copolymersExternal link Chem. Eur. J. 2020 , DOI: 10.1002/chem.202003815.
J. Zhang, B. Farias-Mancilla, I. Kulai, S. Hoeppener, B. Lonetti, S. Prévost, J. Ulbrich, M. Destarac, O. Colombani, U. S. Schubert, C. Guerrero-Sanchez, S. HarrissonEffect of hydrophilic monomer distribution on self-assembly of a pH-responsive copolymer: Spheres, worms and vesicles from a single copolymer compositionExternal link Angew. Chem. Int. Ed. 2020 , DOI: 10.1002/anie.202010501.
D. Bandelli, I. Muljajew, K. Scheuer, J. B. Max, C. Weber, F. H. Schacher, K. D. Jandt, U. S. SchubertCopolymerization of caprolactone isomers to obtain nanoparticles with constant hydrophobicity and tunable crystallinityExternal link Macromolecules 2020 , DOI: 10.1021/acs.macromol.0c00486.
B. Böttcher, B. Hoffmann, E. Garbe, T. Weise, Z. Cseresnyés, P. Brandt, S. Dietrich, D. Driesch, M. T. Figge, S. VylkovaThe transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainabilityExternal link Front. Microbiol. 2020 , 11 , 794.
G. Cinar, C. Englert, M. Lehmann, I. NischangIn situ, quantitative assessment of multifunctional nanoscale drug delivery systems in human serumExternal link Anal. Chem. 2020 , 92 , 7932-7939.
Z. Cseresnyes, M. I. A. Hassan, H.-M. Dahse, K. Voigt, M. T. FiggeQuantitative impact of cell membrane fluorescence labeling on phagocytosis measurements in confrontation assaysExternal link Front. Microbiol. 2020 , DOI: 10.3389/fmicb.2020.01193.
M. A. De Jesús-Téllez, D. M. Sánchez-Cerrillo, P. Quintana-Owen, U. S. Schubert, D. Contreras-López, C. Guerrero-SánchezKinetic investigations of quaternization reactions of poly[2-(dimethylamino)ethyl methacrylate] with diverse alkyl halidesExternal link Macromol. Chem. Phys. 2020 , 221 , 1900543.
A. Medyukhina, M. Blickensdorf, Z. Cseresnyés, N. Ruef, J. V. Stein, M. T. Figge Dynamic spherical harmonics approach for shape classification of migrating cells Sci. Rep. 2020, 10, 6072.
P. Wei, G. Gangapurwala, D. Pretzel, L. Wang, S. Schubert, J. C. Brendel, U. S. SchubertTunable nanogels by host–guest interaction with carboxylate pillar[5]arene for controlled encapsulation and release of doxorubicinExternal link Nanoscale 2020 , 12 , 13595-13605.
A. Barbotin, I. Urbančič, S. Galiani, C. Eggeling, M. Booth, E. Sezginz-STED imaging and spectroscopy to investigate nanoscale membrane structure and dynamicsExternal link Biophys. J. 2020 , 118 , 2448-2457.
A. A. Womiloju, C. Höppener, U. S. Schubert, S. HoeppenerMicrowave-assisted synthesis of core–shell nanoparticles - Insights into the growth of different geometriesExternal link Part. Part. Syst. Charact. 2020 , 2000019.
T. A. Stanly, M. Fritzsche, S. Banerji, D. Shrestha, F. Schneider, C. Eggeling, D. G. JacksonThe cortical actin network regulates avidity-dependent binding of hyaluronan by the Lymphatic Vessel Endothelial receptor LYVE-1External link J. Biol. Chem. 2020 , DOI: 10.1074/jbc.RA1119.011992.
B. Shkodra-Pula, A. Vollrath, U. S. Schubert, S. SchubertPolymer-based nanoparticles for biomedical applicationsExternal link in Frontiers of Nanoscience , Vol. 16 (Eds.: W. J. Parak, N. Feliu), Elsevier, 2020 , pp. 233-252.
B. Shkodra-Pula, C. Kretzer, P. Jordan, P. Klemm, A. Koeberle, D. Pretzel, E. Banoglu, S. Lorkowski, M. Wallert, S. Hoeppener, S. Stumpf, A. Vollrath, S. Schubert, O. Werz, U. S. SchubertEncapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivityExternal link J. Nanobiotechnol. 2020 , DOI: 10.21203/rs.21203.rs-15745/v21201.
E. Sezgin, D. Carugo, I. Levental, E. Stride, C. EggelingCreating supported plasma membrane bilayers using acoustic pressureExternal link bioRxiv 2020 , DOI: 10.1101/2020.1101.1120.912840.
F. Schneider, P. Hernandez-Varas, C. Lagerholm, D. Shrestha, E. Sezgin, J. Roberti, G. Ossato, F. Hecht, C. Eggeling, I. UrbančičHigh photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopyExternal link J. Phys. D: Appl. Phys. 2020 , 53 , 64003.
F. Richter, L. Martin, K. Leer, E. Moek, F. Hausig, J. C. Brendel, A. TraegerTuning of endosomal escape and gene expression by functional groups, molecular weight and transfection medium: a structure–activity relationship studyExternal link J. Mater. Chem. B 2020 , DOI: 10.1039/d1030tb00340a.
T. Hanke, S.-Y. Cheung, W. Kilu, J. Heering, X. Ni, V. Planz, S. Schierle, G. Faudone, M. Friedrich, M. Wanior, O. Werz, M. Windbergs, E. Proschak, M. Schubert-Zsilavecz, A. Chaikuad, S. Knapp, D. MerkA selective modulator of peroxisome proliferator-activated receptor γ with an unprecedented binding modeExternal link J. Med. Chem. 2020 , Doi: 10.1021/acs.jmedchem.1029b01786.
M. Dirauf, C. Grune, C. Weber, U. S. Schubert, D. FischerPoly(ethylene glycol) or poly(2-ethyl-2-oxazoline) – A systematic comparison of PLGA nanoparticles from the bottom upExternal link Eur. Polym. J. 2020 , 134 , 109801.
M. Dirauf, A. Erlebach, C. Weber, S. Hoeppener, J. R. Buchheim, M. Sierka, U. S. SchubertBlock copolymers composed of PEtOx and polyesteramides based on glycolic acid, L-valine, and L-isoleucineExternal link Macromolecules 2020 , DOI: 10.1021/acs.macromol.1020c00282.
M. G. Chini, A. Giordano, M. Potenza, S. Terracciano, K. Fischer, M. C. Vaccaro, E. Colarusso, I. Bruno, R. Riccio, A. Koeberle, O. Werz, G. BifulcoTargeting mPGES-1 by a combinatorial approach: Identification of the aminobenzothiazole scaffold to suppress PGE2 levelsExternal link ACS Med. Chem. Lett. 2020 , DOI: 10.1021/acsmedchemlett.1029b00618.
P. Carravilla, J. L. Nieva, C. EggelingFluorescence microscopy of the HIV-1 envelopeExternal link Viruses 2020 , 12 , 348.
A. Barbotin, I. Urbančič, S. Galiani, C. Eggeling, M. BoothBackground reduction in STED-FCS using coherent-hybrid STEDExternal link bioRxiv 2020 , DOI: 10.1101/2020.1101.1106.895243.
J. Alex, K. González, T. Kindel, P. Bellstedt, C. Weber, T. Heinekamp, T. Orasch, C. Guerrero-Sanchez, U. S. Schubert, A. A. BrakhageCaspofungin functionalized polymethacrylates with antifungal propertiesExternal link Biomacromolecules 2020 , DOI: 10.1021/acs.biomac.0c00096.
H. Lindemann, M. Kühne, C. Grune, P. Warncke, S. Hofmann, A. Koschella, M. Godmann, D. Fischer, T. Heinzel, T. HeinzePolysaccharide nanoparticles bearing HDAC inhibitor as nontoxic nanocarrier for drug deliveryExternal link Macromol. Biosci. 2020 , 2000039.
M. Grube, I. Perevyazko, T. Heinze, U. S. Schubert, I. Nischang,Revisiting very disperse macromolecule populations in hydrodynamic and light scattering studies of sodium carboxymethyl cellulosesExternal link Carbohydr. Polym. 2020 , 229 , 115452.
S. C. Koeberle, A. Gollowitzer, J. Laoukili, O. Kranenburg, O. Werz, A. Koeberle, A. P. KippDistinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanismsExternal link Redox Biology 2020 , 28 , 101388.
I. Muljajew, A. Erlebach, C. Weber, J. R. Buchheim, M. Sierka, U. S. SchubertA polyesteramide library from dicarboxylic acids and 2,2′-bis(2-oxazoline): synthesis, characterization, nanoparticle formulation and molecular dynamics simulationsExternal link Polym. Chem. 2020 , 11 , 112-124.
M. Werner, S. Pace, A. Czapka, P. M. Jordan, J. Gerstmeier, A. Koeberle, O. WerzCommunication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesisExternal link Cell. Mol. Life Sci. 2020 , DOI: 10.1007/s00018-00019-03413-w.
T. Wloka, S. Czich, M. Kleinsteuber, E. Moek, C. Weber, M. Gottschaldt, K. Liefeith, U. S. SchubertMicrofabrication of 3D-hydrogels via two-photon polymerization of poly(2-ethyl-2-oxazoline) diacrylatesExternal link Eur. Polym. J. 2020 , 122 , 109295.
A. M. Ali, T. Deckert-Gaudig, M. Egiza, V. Deckert, T. YoshitakeNear- and far-field Raman spectroscopic studies of nanodiamond composite films deposited by coaxial arc plasmaExternal link Appl. Phys. Lett. 2020 , 116 , 041601.
C. Chen, F. Richter, C. Guerrero-Sanchez, A. Traeger, U. S. Schubert, A. Feng, S. H. ThangCell-penetrating, peptide-based RAFT agent for constructing penetration enhancersExternal link ACS Macro Letters 2020 , 9 , 260-265.
C. Cokca, L. Zartner, I. Tabujew, D. Fischer, K. PenevaIncorporation of indole significantly improves the transfection efficiency of guanidinium-containing poly(methacrylamide)sExternal link Macromol. Rapid Commun. 2020 , 41 , 2070012.
J. A. Czaplewska, G. Gangapurwala, A. Vollrath, M. Pröhl, T. Majdanski, D. Pretzel, S. Hoeppener, U. S. Schubert, M. GottschaldtSynthesis of a fructose decorated PAGE-b-PEG-b-PLGA polymer with subsequent formulation of nanoparticlesExternal link Colloids Surf. A Physicochem. Eng. Asp. 2020 , 124701.
S. Deinhardt-Emmer, K. Rennert, E. Schicke, Z. Cseresnyés, M. Windolph, S. Nietzsche, R. Heller, F. Siwczak, K. F. Haupt, S. Carlstedt, M. Schacke, M. T. Figge, C. Ehrhardt, B. Löffler, A. S. MosigCo-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip modelExternal link Biofabrication 2020 , 12 , 025012.
A. Erlebach, I. Muljajew, M. Chi, C. Bückmann, C. Weber, U. S. Schubert, M. SierkaPredicting solubility of small molecules in macromolecular compounds for nanomedicine application from atomistic simulationsExternal link Adv. Theory Simul. 2020 , DOI: 10.1002/adts.202000001.
E. Gardey, F. H. Sobotta, S. Hoeppener, T. Bruns, A. Stallmach, J. C. BrendelInfluence of core cross-linking and shell composition of polymeric micelles on immune response and their interaction with human monocytesExternal link Biomacromolecules 2020 , DOI: 10.1021/acs.biomac.9b01656.
M. Gericke, P. Schulze, T. HeinzeNanoparticles based on hydrophobic polysaccharide derivatives—formation principles, characterization techniques, and biomedical applicationsExternal link Macromol. Biosci. 2020 , 1900415.
M. Grube, G. Cinar, U. S. Schubert, I. NischangIncentives of using the hydrodynamic invariant and sedimentation parameter for the study of naturally- and synthetically-based macromolecules in solutionExternal link Polymers 2020 , 12 , 277.
K. Hiesinger, A. Schott, J. S. Kramer, R. Blöcher, F. Witt, S. K. Wittmann, D. Steinhilber, D. Pogoryelov, J. Gerstmeier, O. Werz, E. ProschakDesign of dual inhibitors of soluble epoxide hydrolase and LTA4 hydrolaseExternal link ACS Med. Chem. Lett. 2020 , 11 , 298-302.
C. Höppener, F. H. Schacher, V. DeckertMultimodal characterization of resin embedded and sliced polymer nanoparticles by means of tip-enhanced raman spectroscopy and force–distance curve based atomic force microscopyExternal link Small 2020 , 1907418.
J. Hübner, T. Deckert-Gaudig, J. Glorian, V. K. Deckert, D. SpitzerSurface characterization of nanoscale co-crystals enabled through tip enhanced raman spectroscopyExternal link Nanoscale 2020 , DOI: 10.1039/D1030NR00397B.
S. M. A. S. Keshk, A. A. El-Zahhar, Q. A. Alsulami, M. Jaremko, S. Bondock, T. HeinzeSynthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate compositeExternal link Cellulose 2020 , 27 , 1603-1618.
A. Koschella, C.-Y. Chien, T. Iwata, M. S. Thonhofer, T. M. Wrodnigg, T. HeinzeAll sugar based cellulose derivatives synthesized by azide–alkyne click chemistryExternal link Macromol. Chem. Phys. 2020 , 221 , 1900343.
G. Lauro, S. Terracciano, V. Cantone, D. Ruggiero, K. Fischer, S. Pace, O. Werz, I. Bruno, G. BifulcoA combinatorial virtual screening approach driving the synthesis of 2,4-thiazolidinedione-based molecules as new dual mPGES-1/5-LO inhibitorsExternal link ChemMedChem 2020 , 15 , 481-489.
V. D. Lechuga-Islas, G. Festag, M. Rosales-Guzmán, O. E. Vega-Becerra, R. Guerrero-Santos, U. S. Schubert, C. Guerrero-SánchezQuasi-block copolymer design of quaternized derivatives of poly(2-(dimethylamino)ethyl methacrylate): Investigations on thermo-induced self-assemblyExternal link Eur. Polym. J. 2020 , 124 , 109457.
E. Matuszyk, E. Sierka, M. Rodewald, H. Bae, T. Meyer, E. Kus, S. Chlopicki, M. Schmitt, J. Popp, M. BaranskaDifferential response of liver sinusoidal endothelial cells and hepatocytes to oleic and palmitic acid revealed by Raman and CARS imagingExternal link Biochim. Biophys. Acta Mol. Basis Disease 2020 , 1866 , 165763.
J. B. Max, P. J. Mons, J. C. Tom, F. H. SchacherDouble hydrophilic poly(ethylene oxide)-block-poly(dehydroalanine) block copolymers: Comparison of two different synthetic routesExternal link Macromol. Chem. Phys. 2020 , 221 , 1900383.
A. Olgac, A. Carotti, C. Kretzer, S. Zergiebel, A. Seeling, U. Garscha, O. Werz, A. Macchiarulo, E. BanogluDiscovery of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by exploiting a multistep virtual screening protocolExternal link J. Chem. Inf. Model. 2020 , 60 , 1737-1748.
Z. Rao, P. M. Jordan, Y. Wang, D. Menche, S. Pace, J. Gerstmeier, O. WerzDifferential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytesExternal link Biochem. Pharmacol. 2020 , 175 , 113858.
V. V. Shumyantseva, T. V. Bulko, A. V. Kuzikov, R. A. Masamrekh, A. Y. Konyakhina, I. Romanenko, J. B. Max, M. Köhler, A. A. Gilep, S. A. Usanov, D. V. Pergushov, F. H. Schacher, L. V. SigolaevaAll-electrochemical nanocomposite two-electrode setup for quantification of drugs and study of their electrocatalytical conversion by cytochromes P450External link Electrochimica Acta 2020 , 336 , 135579.
P. Singh, T. Deckert-Gaudig, Z. Zhang, V. DeckertPlasmon induced deprotonation of 2-mercaptopyridineExternal link Analyst 2020 , 145 , 2106-2110.
M. Sittig, B. Schmidt, H. Görls, T. Bocklitz, M. Wächtler, S. Zechel, M. D. Hager, B. DietzekFluorescence upconversion by triplet-triplet annihilation in all-organic poly(methacrylate)-terpolymersExternal link Phys. Chem. Chem. Phys. 2020 , 22 , 4072-4079.
R. Takahashi, S. Miwa, F. H. Sobotta, J. H. Lee, S. Fujii, N. Ohta, J. C. Brendel, K. SakuraiUnraveling the kinetics of the structural development during polymerization-induced self-assembly: decoupling the polymerization and the micelle structureExternal link Polym. Chem. 2020 , 11 , 1514-1524.
A. Traeger, S. Voelker, B. Shkodra-Pula, C. Kretzer, S. Schubert, M. Gottschaldt, U. S. Schubert, O. WerzImproved bioactivity of the natural product 5-lipoxygenase inhibitor hyperforin by encapsulation into polymeric nanoparticlesExternal link Mol. Pharm. 2020 , 17 , 810-816.
P. Wei, J. A. Czaplewska, L. Wang, S. Schubert, J. C. Brendel, U. S. SchubertStraightforward access to glycosylated, acid sensitive nanogels by host–guest interactions with sugar-modified pillar[5]arenesExternal link ACS Macro Letters 2020 , 9 , 540-545.
P. Wei, F. H. Sobotta, C. Kellner, D. Bandelli, S. Hoeppener, S. Schubert, J. C. Brendel, U. S. SchubertDegradable polycaprolactone nanoparticles stabilized via supramolecular host–guest interactions with pH-responsive polymer-pillar[5]arene conjugatesExternal link Polym. Chem. 2020 , 11 , 1985-1997.
F. Wendler, J. C. Tom, M. Sittig, P. Biehl, B. Dietzek, F. H. SchacherBlock copolymers featuring highly photostable photoacids based on vinylnaphthol: Synthesis and self-assemblyExternal link Macromol. Rapid Commun. 2020 , 41 , 1900607.
2019
N. Köse-Vogel, S. Stengel, E. Gardey, T. Kirchberger-Tolstik, P. A. Reuken, A. Stallmach, T. BrunsTranscriptional suppression of the NLRP3 inflammasome and cytokine release in primary macrophages by low-dose anthracyclinesExternal link Cells 2019 , 9 , 79.
G. Creusen, A. Roshanasan, J. Garcia Lopez, K. Peneva, A. WaltherBottom-up design of model network elastomers and hydrogels from precise star polymersExternal link Polym. Chem. 2019 , 10 , 3740-3750.
F. Wendler, J. C. Tom, F. H. SchacherSynthesis and self-assembly of photoacid-containing block copolymers based on 1-naphtholExternal link Polym. Chem. 2019 , 10 , 5602-5616.
D. Bandelli, J. Alex, C. Weber, U. S. SchubertPolyester stereocomplexes beyond PLA: Could synthetic opportunities revolutionize established material blending?External link Macromol. Rapid Commun. 2019 , 1900560.
T. Chakraborty, M. K. Driscoll, E. Jeffery, M. M. Murphy, P. Roudot, B.-J. Chang, S. Vora, W. M. Wong, C. D. Nielson, H. Zhang, V. Zhemkov, C. Hiremath, E. D. De La Cruz, Y. Yi, I. Bezprozvanny, H. Zhao, R. Tomer, R. Heintzmann, J. P. Meeks, D. K. Marciano, S. J. Morrison, G. Danuser, K. M. Dean, R. FiolkaLight-sheet microscopy of cleared tissues with isotropic, subcellular resolutionExternal link Nat. Meth. 2019 , 16 , 1109-1113.
C. Favard, J. Chojnacki, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling, D. MuriauxHIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assemblyExternal link Sci. Adv. 2019 , 5 , eaaw8651.
E. Romp, V. Arakandy, J. Fischer, C. Wolz, A. Siegmund, B. Löffler, L. Tuchscherr, O. Werz, U. GarschaExotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesisExternal link Cell. Mol. Life Sci. 2019 , DOI: 10.1007/s00018-00019-03393-x.
M. Rosales-Guzmán, O. Pérez-Camacho, C. Guerrero-Sánchez, S. Harrisson, R. Torres-Lubián, J. Vitz, U. S. Schubert, E. Saldívar-GuerraSemiautomated parallel RAFT copolymerization of isoprene with glycidyl methacrylateExternal link ACS Comb. Sci. 2019 , 21 , 771-781.
F. Wendler, M. Sittig, J. C. Tom, B. Dietzek, F. H. SchacherPolymeric photoacids based on naphthols - Design criteria, photostability, and light-mediated releaseExternal link Chem. Eur. J. 2019 , DOI: 10.1002/chem.201903819.
R. Meyer, S. Trautmann, K. Rezaei, A. George, A. Turchanin, V. DeckertSynergy of photoinduced force microscopy and tip-enhanced Raman spectroscopy—A correlative study on MoS2External link ACS Photonics 2019 , 6 , 1191-1198.
J. B. Max, D. V. Pergushov, L. V. Sigolaeva, F. H. SchacherPolyampholytic graft copolymers based on polydehydroalanine (PDha) – synthesis, solution behavior and application as dispersants for carbon nanotubesExternal link Polym. Chem. 2019 , 10 , 3006-3019.
J. Langer, D. Jimenez de Aberasturi, J. Aizpurua, R. A. Alvarez-Puebla, B. Auguié, J. J. Baumberg, G. C. Bazan, S. E. J. Bell, A. Boisen, A. G. Brolo, J. Choo, D. Cialla-May, V. Deckert, L. Fabris, K. Faulds, F. J. García de Abajo, R. Goodacre, D. Graham, A. J. Haes, C. L. Haynes, C. Huck, T. Itoh, M. Käll, J. Kneipp, N. A. Kotov, H. Kuang, E. C. Le Ru, H. K. Lee, J.-F. Li, X. Y. Ling, S. Maier, T. Mayerhoefer, M. Moskovits, K. Murakoshi, J.-M. Nam, S. Nie, Y. Ozaki, I. Pastoriza-Santos, J. Perez-Juste, J. Popp, A. Pucci, S. Reich, B. Ren, G. C. Schatz, T. Shegai, S. Schlücker, T. Li-Lin, K. G. Thomas, Z.-Q. Tian, R. P. Van Duyne, T. Vo-Dinh, Y. Wang, K. A. Willets, C. Xu, H. Xu, Y. Xu, Y. S. Yamamoto, B. Zhao, L. M. Liz-MarzánPresent and future of surface enhanced Raman scatteringExternal link ACS Nano 2019 , DOI: 10.1021/acsnano.1029b04224.
J. Ernst, M. Klinger-Strobel, J. Thamm, O. Makarewicz, M. Pletz, D. Fischer Breaking the biofilm barrier: The role of stabilizers in biofilm penetration and pulmonary antibiotic delivery by polymer nanoparticlesPharmazeutische Industrie 2019 , 81 , 248-255.
J. K. Elter, P. Biehl, M. Gottschaldt, F. H. SchacherCore-crosslinked worm-like micelles from polyether-based diblock terpolymersExternal link Polym. Chem. 2019 , DOI: 10.1039/C1039PY01054H.
V. H. Bac, B. S. Paulsen, L. V. Truong, A. Koschella, T. C. Trinh, C. W. Wold, S. Yogarajah, T. HeinzeNeutral polysaccharide from the leaves of pseuderanthemum carruthersii: Presence of 3-O-methyl galactose and anti-inflammatory activity in LPS-stimulated RAW 264.7 cellsExternal link Polymers 2019 , 11 , 1219.
L. Applová, J. Karlíčková, P. Warncke, K. Macáková, M. Hrubša, M. Macháček, V. Tvrdý, D. Fischer, P. Mladěnka4-Methylcatechol, a flavonoid metabolite with potent antiplatelet effectsExternal link Mol. Nutr. Food Res. 2019 , 63 , 1900261.
I. Perevyazko, A. Lezov, A. S. Gubarev, E. Lebedeva, G. Festag, C. Guerrero-Sanchez, N. Tsvetkov, U. S. SchubertStructure-property relationships via complementary hydrodynamic approaches: Poly(2-(dimethylamino)ethyl methacrylate)sExternal link Polymer 2019 , 182 , 121828.
L. V. Sigolaeva, T. V. Bulko, M. S. Kozin, W. Zhang, M. Köhler, I. Romanenko, J. Yuan, F. H. Schacher, D. V. Pergushov, V. V. ShumyantsevaLong-term stable poly(ionic liquid)/MWCNTs inks enable enhanced surface modification for electrooxidative detection and quantification of dsDNAExternal link Polymer 2019 , 168 , 95-103.
C. St Thomas, C. N. Muñoz López, E. J. Jiménez Regalado, M. A. de Jesús Tellez, G. Festag, U. S. Schubert, C. Guerrero-SánchezPreparation of hydrophobically modified associating multiblock copolymers via a one-pot aqueous RAFT polymerizationExternal link Polym. Chem. 2019 , DOI: 10.1039/C1039PY01311C.
M. Wang, J. Zhang, C. Guerrero-Sanchez, U. S. Schubert, A. Feng, S. H. ThangEnzyme degassing for oxygen-sensitive reactions in open vessels of an automated parallel synthesizer: RAFT polymerizationsExternal link ACS Comb. Sci. 2019 , 21 , 643-649.
M. Wallert, M. Ziegler, X. Wang, A. Maluenda, X. Xu, M. L. Yap, R. Witt, C. Giles, S. Kluge, M. Hortmann, J. Zhang, P. Meikle, S. Lorkowski, K. Peterα-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injuryExternal link Redox Biology 2019 , 26 , 101292.
H. L. Cao, X. Y. Liu, K. D. JandtThe action-network of nanomaterialsExternal link in "On the issue of transparency and reproducibility in nanomedicine"External link Nat. Nanotechn. 2019 , 14 , 629-635.
D. Bandelli, C. Weber, U. S. SchubertStrontium isopropoxide: A highly active catalyst for the ring-opening polymerization of lactide and various lactonesExternal link Macromol. Rapid Commun. 2019 , 1900306.
Z. Rao, S. Pace, P. M. Jordan, R. Bilancia, F. Troisi, F. Börner, N. Andreas, T. Kamradt, D. Menche, A. Rossi, C. N. Serhan, J. Gerstmeier, O. WerzVacuolar (H+)-ATPase critically regulates specialized proresolving mediator pathways in human M2-like monocyte-derived macrophages and has a crucial role in resolution of inflammationExternal link J. Immunol. 2019 , 203 , 1031-1043.
H. Würfel, M. Kayser, T. HeinzeNon-aqueous solvent for efficient dissolution of polygalacturonic acidExternal link Carbohydr. Polym. 2019 , 207 , 791-795.
H. Würfel, M. Kayser, T. HeinzeTrimethylsilylation of Polygalacturonic AcidExternal link Macromol. Chem. Phys. 2019 , 220 , 1900002.
M. Kostag, M. Gericke, T. Heinze, O. A. El SeoudTwenty-five years of cellulose chemistry: innovations in the dissolution of the biopolymer and its transformation into esters and ethersExternal link Cellulose 2019 , 26 , 139-184.
C. Pinon-Balderrama, C. Leyva-Porras, R. Olayo-Valles, J. Revilla-Vazquez, U. S. Schubert, C. Guerrero-Sanchez, J. Bonilla-CruzSelf-assembly investigations of sulfonated poly(methyl methacrylate-block-styrene) diblock copolymer thin filmsExternal link Adv. Polym. Technol. 2019 , 2019 , 11.
A. Sierra-Fernandez, S. C. De la Rosa-García, R. Yañez-Macías, C. Guerrero-Sanchez, L. S. Gomez-Villalba, S. Gómez-Cornelio, M. E. Rabanal, U. S. Schubert, R. Fort, P. QuintanaSol–gel synthesis of Mg(OH)2 and Ca(OH)2 nanoparticles: a comparative study of their antifungal activity in partially quaternized p(DMAEMA) nanocomposite filmsExternal link J. Sol-Gel Sci. Technol. 2019 , 89 , 310-321.
M. Zink, K. Hotzel, U. S. Schubert, T. Heinze, D. FischerAmino Acid–Substituted Dextran-Based Non-Viral Vectors for Gene DeliveryExternal link Macromol. Biosci. 2019 , 19 , 1900085.
J. Gerstmeier, C. Kretzer, S. Di Micco, L. Miek, H. Butschek, V. Cantone, R. Bilancia, R. Rizza, F. Troisi, N. Cardullo, C. Tringali, A. Ialenti, A. Rossi, G. Bifulco, O. Werz, S. PaceNovel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapyExternal link Biochem. Pharmacol. 2019 , 165 , 263-274.
J. Gerstmeier, J. Seegers, F. Witt, B. Waltenberger, V. Temml, J. M. Rollinger, H. Stuppner, A. Koeberle, D. Schuster, O. WerzGinkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator BiosynthesisExternal link Frontiers in Pharmacology 2019 , 10.
S. Shekfeh, B. Çalışkan, K. Fischer, T. Yalçın, U. Garscha, O. Werz, E. BanogluA Multi‐step Virtual Screening Protocol for the Identification of Novel Non‐acidic Microsomal Prostaglandin EExternal link 2 Synthase‐1 (mPGES‐1) InhibitorsExternal link ChemMedChem 2019 , 14 , 273-281.
M. Wallert, J. Bauer, S. Kluge, L. Schmölz, Y.-C. Chen, M. Ziegler, A. K. Searle, A. Maxones, M. Schubert, M. Thürmer, H. Pein, A. Koeberle, O. Werz, M. Birringer, K. Peter, S. LorkowskiThe vitamin E derivative garcinoic acid fromExternal link Garcinia kola nut seeds attenuates the inflammatory responseExternal link Redox Biology 2019 , 24 , 101166.
M. Reifarth, W. Müller, B. Shkodra-Pula, H. Görls, U. S. Schubert, R. Heintzmann, S. HoeppenerElectron density of polymeric nanoparticles determined by image processing of transmission electron micrographs: Insights into heavy metal staining processesExternal link Particle & Particle Systems Characterization 2019 , 1800324.
M. Sahn, C. Weber, U. S. SchubertPoly(2-oxazoline)-containing triblock copolymers: Synthesis and applicationsExternal link Polym. Rev. 2019 , doi: 10.1080/15583724.2018.1496930.
P. Wei, G. Gangapurwala, D. Pretzel, M. N. Leiske, L. Wang, S. Hoeppener, S. Schubert, J. C. Brendel, U. S. SchubertSmart pH-sensitive nanogels for controlled release in an acidic environmentExternal link Biomacromolecules 2019 , 20 , 130-140.
M. Werner, P. M. Jordan, E. Romp, A. Czapka, Z. Rao, C. Kretzer, A. Koeberle, U. Garscha, S. Pace, H.-E. Claesson, C. N. Serhan, O. Werz, J. GerstmeierTargeting biosynthetic networks of the proinflammatory and proresolving lipid metabolomeExternal link The FASEB Journal 2019 , doi: 10.1096/fj.201802509R.
L. Wondraczek, G. Pohnert, F. H. Schacher, A. Köhler, M. Gottschaldt, U. S. Schubert, K. Küsel, A. A. BrakhageArtificial microbial arenas: Materials for observing and manipulating microbial consortiaExternal link Adv. Mater. 2019 , 31 , 1900284.
B. Shkodra-Pula, C. Grune, A. Traeger, A. Vollrath, S. Schubert, D. Fischer, U. S. SchubertEffect of surfactant on the size and stability of PLGA nanoparticles encapsulating a protein kinase C inhibitorExternal link Int. J. Pharm. 2019 , 566 , 756-764.
C. Reichardt, S. Monro, F. H. Sobotta, K. L. Colón, T. Sainuddin, M. Stephenson, E. Sampson, J. Roque, H. Yin, J. C. Brendel, C. G. Cameron, S. McFarland, B. DietzekPredictive strength of photophysical measurements for in vitro photobiological activity in a series of Ru(II) polypyridyl complexes derived from π-extended ligandsExternal link Inorg. Chem. 2019 , 58 , 3156-3166.
H. Qiu, Z. Yang, M. Köhler, J. Ling, F. H. SchacherSynthesis and solution self-assembly of poly(1,3-dioxolane)External link Macromolecules 2019 , 52 , 3359-3366.
N. Engel, M. Dirauf, S. Seupel, M. N. Leiske, S. Schubert, U. S. SchubertUtilization of 4-(trifluoromethyl)benzenesulfonates as counter ions tunes the initiator efficiency of sophisticated initiators for the preparation of well-defined poly(2-oxazoline)sExternal link Macromol. Rapid Commun. 2019 , 40 , 1900094.
N. Al Nakeeb, I. Nischang, B. V. K. J. SchmidtTannic acid-mediated aggregate stabilization of poly(N-vinylpyrrolidone)-b-poly(oligo (ethylene glycol) methyl ether methacrylate) double hydrophilic block copolymersExternal link Nanomaterials 2019 , 9 , 662.
M. Maurer, M. S. Gresnigt, A. Last, T. Wollny, F. Berlinghof, R. Pospich, Z. Cseresnyes, A. Medyukhina, K. Graf, M. Gröger, M. Raasch, F. Siwczak, S. Nietzsche, I. D. Jacobsen, M. T. Figge, B. Hube, O. Huber, A. S. MosigA three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studiesExternal link Biomaterials 2019 , 220 , 119396.
M. I. A. Hassan, Z. Cseresnyes, N. Al-Zaben, H.-M. Dahse, R. J. Vilela de Oliveira, G. Walther, K. Voigt, M. T. FiggeThe geographical region of origin determines the phagocytic vulnerability of Lichtheimia strainsExternal link Environ. Microbiol. , DOI: 10.1111/1462-2920.14752.
D. Bandelli, J. Alex, C. Helbing, N. Ueberschaar, H. Görls, P. Bellstedt, C. Weber, K. D. Jandt, U. S. SchubertPoly(ethylglycolide): A well-defined polyester matching the hydrophilic hydrophobic balance of PLAExternal link Polym. Chem. 2019 , DOI: 10.1039/c1039py00875f.
I. Tabujew, C. Cokca, L. Zartner, U. S. Schubert, I. Nischang, D. Fischer, K. PenevaThe influence of gradient and statistical arrangements of guanidinium or primary amine groups in poly(methacrylate) copolymers on their DNA binding affinityExternal link Journal of Materials Chemistry B 2019, DOI: 10.1039/c9tb01269a.
A. Barbotin, S. Galiani, I. Urbančič, C. Eggeling, M. J. BoothAdaptive optics allows STED-FCS measurements in the cytoplasm of living cellsExternal link Optics Express 2019 , 27 , 23378-23395.
T. Klein, F. V. Gruschwitz, S. Rogers, S. Hoeppener, I. Nischang, J. C. BrendelThe influence of directed hydrogen bonds on the self-assembly of amphiphilic polymers in waterExternal link J. Colloid Interface Sci. 2019 , 557 , 488-497.
M. E. Mikhailova, A. S. Senchukova, A. A. Lezov, A. S. Gubarev, A.-K. Trützschler, U. S. Schubert, N. V. TsvetkovStabilization of Silver Nanoparticles by Cationic Aminoethyl Methacrylate Copolymers in Aqueous Media—Effects of Component Ratios and Molar Masses of CopolymersExternal link Polymers 2019 , 11 , 1647.
M. Raasch, E. Fritsche, A. Kurtz, M. Bauer, A. S. MosigMicrophysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug developmentExternal link Adv. Drug Delivery Rev. 2019 , 140 , 51-67.
E. Rossegger, F. Pirolt, S. Hoeppener, U. S. Schubert, O. Glatter, F. WiesbrockCrosslinkable/functionalizable poly(2-oxazoline)based micellesExternal link Eur. Polym. J. 2019 , 121 , 109305.
I. Tabujew, M. Heidari, C. Freidel, M. Helm, L. Tebbe, U. Wolfrum, K. Nagel-Wolfrum, K. Koynov, P. Biehl, F. H. Schacher, R. Potestio, K. PenevaTackling the limitations of copolymeric small interfering RNA delivery agents by a combined experimental–computational approachExternal link Biomacromolecules 2019 , 20 , 4389-4406.
I. Tabujew, M. Willig, N. Leber, C. Freidel, I. Negwer, K. Koynov, M. Helm, K. Landfester, R. Zentel, K. Peneva, V. MailänderOvercoming the barrier of CD8+ T cells: Two types of nano-sized carriers for siRNA transportExternal link Acta Biomaterialia 2019 , 100 , 338-351.
R. Yañez-Macías, A. Muñoz-Bonilla, M. A. De Jesús-Tellez, H. Maldonado-Textle, C. Guerrero-Sánchez, U. S. Schubert, R. Guerrero-SantosCombinations of antimicrobial polymers with nanomaterials and bioactives to improve biocidal therapiesExternal link Polymers 2019 , 11 , 1789.
M. Yarbakht, P. Pradhan, N. Köse-Vogel, H. Bae, S. Stengel, T. Meyer, M. Schmitt, A. Stallmach, J. Popp, T. W. Bocklitz, T. BrunsNonlinear multimodal imaging characteristics of early septic liver injury in a mouse model of peritonitisExternal link Anal. Chem. 2019 , 91 , 11116-11121.
2018
F. L. Kriegel, R. Köhler, J. Bayat-Sarmadi, S. Bayerl, A. E. Hauser, R. Niesner, A. Luch, Z. CseresnyesMorphology-based distinction between healthy and pathological cells utilizing fourier transforms and self-organizing mapsExternal link JoVE 2018 , e58543.
N. Teich, T. Bruns, A. StallmachLetter: predicting azathioprine-associated pancreatitis in IBD—phenotype or genotype?External link Aliment. Pharmacol. Ther. 2018 , 47 , 1042-1043.
C. Englert, J. C. Brendel, T. C. Majdanski, T. Yildirim, S. Schubert, M. Gottschaldt, N. Windhab, U. S. Schubert, "Pharmapolymers in the 21st Century: Synthetic Polymers in Drug Delivery ApplicationsExternal link ", Prog. Polym. Sci. 2018 , DOI: 10.1016/j.progpolymsci.2018.1007.1005.
P. Dasari, I. A. Shopova, M. Stroe, D. Wartenberg, H. Martin-Dahse, N. Beyersdorf, P. Hortschansky, S. Dietrich, Z. Cseresnyés, M. T. Figge, M. Westermann, C. Skerka, A. A. Brakhage, P. F. Zipfel, "Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damageExternal link ", Front. Immunol. 2018 , 9 , 1635.
L. Vieider, E. Romp, V. Temml, J. Fischer, C. Kretzer, M. Schoenthaler, A. Taha, V. Hernández-Olmos, S. Sturm, D. Schuster, O. Werz, U. Garscha, B. Matuszczak, "Synthesis, biological evaluation and structureactivity relationships of diflapolin analogues as dual sEH/FLAP inhibitorsExternal link ", ACS Med. Chem. Lett. 2018 , DOI: 10.1021/acsmedchemlett.8b00415.
M. Brunzel, T. Majdanski, J. Vitz, I. Nischang, U. Schubert, "Fast screening of diol impurities in methoxy poly(ethylene glycol)s (mPEG)s by liquid chromatography on monolithic silica rodsExternal link ", Polymers 2018 , 10 , 1395.
T. C. Majdanski, J. Vitz, A. Meier, M. Brunzel, S. Schubert, I. Nischang, U. S. Schubert, "Green ethers as solvent alternatives for anionic ring-opening polymerizations of ethylene oxide (EO): In-situ kinetic and advanced characterization studiesExternal link ", Polymer 2018 , 159 , 86-94.
M. Dirauf, D. Bandelli, C. Weber, H. Görls, M. Gottschaldt, U. S. Schubert, "TBD-catalyzed ring-opening polymerization of alkyl-substituted morpholine-2,5-dione derivativesExternal link ", Macromol. Rapid Commun. 2018 , 39 , 1800433.
H. Pein, A. Ville, S. Pace, V. Temml, U. Garscha, M. Raasch, K. Alsabil, G. Viault, C.-P. Dinh, D. Guilet, F. Troisi, K. Neukirch, S. König, R. Bilancia, B. Waltenberger, H. Stuppner, M. Wallert, S. Lorkowski, C. Weinigel, S. Rummler, M. Birringer, F. Roviezzo, L. Sautebin, J.-J. Helesbeux, D. Séraphin, A. Mosig, D. Schuster, A. Rossi, P. Richomme, O. Werz, A. Koeberle, "Endogenous metabolites of vitamin E limit inflammation by targeting 5 lipoxygenaseExternal link ", Nat. Commun. 2018 , 9 , 3834.
H. Würfel, M. Kayser, T. Heinze, "Efficient and catalyst-free synthesis of cellulose acetoacetatesExternal link ", Cellulose 2018 , 25 , 4919-4928.
K. Ganske, T. Heinze, "Evaluation of the synthesis of soluble aromatic cellulose carbonates of low degree of substitutionExternal link ",Macromol. Chem. Phys. 2018 , 219 , 1800152.
T. Bus, A. Traeger, U. S. Schubert, "The great escape: how cationic polyplexes overcome the endosomal barrierExternal link ", J. Mater. Chem. B 2018 , 6 , 6904-6918.
M. Bauer, L. Tauhardt, H. M. L. Lambermont-Thijs, K. Kempe, R. Hoogenboom, U. S. Schubert, D. Fischer, "Rethinking the impact of the protonable amine density on cationic polymers for gene delivery: A comparative study of partially hydrolyzed poly(2-ethyl-2-oxazoline)s and linear poly(ethylene imine)sExternal link ", Eur. J. Pharm. Biopharm. 2018 , 133 , 112-121.
J. F. Herrmann, C. Höppener, "Dumbbell gold nanoparticle dimer antennas with advanced optical propertiesExternal link ", Beilst. J. Nanotechnol. 2018 , 9 , 2188-2197.
R. Meyer, X. Yao, V. Deckert, "Latest instrumental developments and bioanalytical applications in tip-enhanced Raman spectroscopyExternal link ", Trends Anal. Chem. 2018 , 102 , 250-258.
D. Bandelli, C. Helbing, C. Weber, M. Seifert, I. Muljajew, K. D. Jandt, U. S. Schubert, "Maintaining the hydrophilichydrophobic balance of polyesters with adjustable crystallinity for tailor-made nanoparticlesExternal link ", Macromolecules 2018 , 51 , 5567-5576.
S.-Y. Cheung, M. Werner, L. Esposito, F. Troisi, V. Cantone, S. Liening, S. König, J. Gerstmeier, A. Koeberle, R. Bilancia, R. Rizza, A. Rossi, F. Roviezzo, V. Temml, D. Schuster, H. Stuppner, M. Schubert-Zsilavecz, O. Werz, T. Hanke, S. Pace, "Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammationExternal link ", Eur. J. Med. Chem. 2018 , 156 , 815-830.
A. Koeberle, A. Henkel, M. Verhoff, L. Tausch, S. König, D. Fischer, N. Kather, S. Seitz, M. Paul, J. Jauch, O. Werz, "Triterpene acids from Frankincense and semi-synthetic derivatives that inhibit 5-lipoxygenase and cathepsin GExternal link ", Molecules 2018 , 23 , 506.
A.-K. Trützschler, T. Bus, M. Sahn, A. Traeger, C. Weber, U. S. Schubert, "The power of shielding: Low toxicity and high transfection performance of cationic graft copolymers containing poly(2-oxazoline) side chainsExternal link ", Biomacromolecules 2018 , 19 , 2759-2771.
M. Grube, M. N. Leiske, U. S. Schubert, I. Nischang, "POx as an alternative to PEG? A hydrodynamic and light scattering studyExternal link ", Macromolecules 2018 , 51 , 1905-1916.
Z. T. Gür, B. Çalışkan, U. Garscha, A. Olgaç, U. S. Schubert, J. Gerstmeier, O. Werz, E. Banoglu, "Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7External link ", Eur. J. Med. Chem. 2018 , 150 , 876-899.
D. Hertz, M. N. Leiske, T. Wloka, A. Traeger, M. Hartlieb, M. M. Kessels, S. Schubert, B. Qualmann, U. S. Schubert, "Comparison of random and gradient amino functionalized poly(2-oxazoline)s: Can the transfection efficiency be tuned by the macromolecular structure?External link ", J. Polym. Sci., Part A: Polym. Chem. 2018 , DOI: 10.1002/pola.29000.
M. N. Leiske, F. H. Sobotta, F. Richter, S. Hoeppener, J. C. Brendel, A. Traeger, U. S. Schubert, "How to tune the gene delivery and biocompatibility of poly(2-(4-aminobutyl)-2-oxazoline) by self- and coassemblyExternal link ", Biomacromolecules 2018 , 19 , 748-760.
I. Muljajew, C. Weber, I. Nischang, U. Schubert, "PMMA-g-OEtOx graft copolymers: Influence of grafting degree and side chain length on the conformation in aqueous solutionExternal link ", Materials 2018 , 11 , 528.
M. Reifarth, S. Hoeppener, U. S. Schubert, "Uptake and intracellular fate of engineered nanoparticles in mammalian cells: Capabilities and limitations of transmission electron microscopypolymerbased nanoparticlesExternal link ", Adv. Mater. 2018 , 30 , 1703704.
W. S. Zhang, X. Q. Yu, Y. Li, Z. Q. Su, K. D. Jandt, G. Wei, "Protein-mimetic peptide nanofibers: Motif design, self-assembly synthesis, and sequence-specific biomedical applicationsExternal link ", Prog. Polym. Sci. 2018 , 80 , 94-124.
M. Reifarth, U. S. Schubert, S. Hoeppener, "Considerations for the uptake characteristic of inorgainc nanoparticles into mammalian cells - Insights gained by TEM investigationsExternal link ", Adv. Biosys. 2018 , DOI: 10.1002/adbi.201700254.
M. Sahn, L. M. Stafast, M. Dirauf, D. Bandelli, C. Weber, U. S. Schubert, "LCST behavior of poly(2-ethyl-2-oxazoline) containing diblock and triblock copolymersExternal link ", Eur. Polym. J. 2018 , 100 , 57-66.
F. H. Sobotta, F. Hausig, D. O. Harz, S. Hoeppener, U. S. Schubert, J. C. Brendel, "Oxidation-responsive micelles by a one-pot polymerization-induced self-assembly approachExternal link ", Polym. Chem. 2018 , 9 , 1593-1602.
P. Wei, S. Götz, S. Schubert, J. C. Brendel, U. S. Schubert, "Accelerating the acidic degradation of a novel thermoresponsive polymer by host-guest interactionExternal link ", Polym. Chem. 2018 , 9 , 2634-2642.
A.-K. Trützschler, T. Bus, M. Reifarth, J. C. Brendel, S. Hoeppener, A. Traeger, U. S. Schubert, "Beyond gene transfection with methacrylate-based polyplexesthe influence of the amino substitution patternExternal link ", Bioconjugate Chem. 2018 , 29 , 2181-2194.
A. Koeberle, O. Werz, "Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesisExternal link ", Biotechnol. Adv. 2018 , 36 , 1709-1723.
L. Volkmann, M. Köhler, F. H. Sobotta, M. T. Enke, J. C. Brendel, F. H. Schacher, "Poly(2-acrylamidoglycolic acid) (PAGA): Controlled polymerization using RAFT and chelation of metal cationsExternal link ", Macromolecules 2018 , DOI: 10.1021/acs.macromol.1028b01260.
J. Zhang, B. Farias-Mancilla, M. Destarac, U. S. Schubert, D. J. Keddie, C. Guerrero-Sanchez, S. Harrisson,"Asymmetric copolymers: Synthesis, properties, and applications of gradient and other partially segregated copolymersExternal link ", Macromol. Rapid Commun. 2018 , 39 , 1800357.
S. Miwa, R. Takahashi, C. Rössel, S. Matsumoto, S. Fujii, J. H. Lee, F. H. Schacher, K. SakuraiCore–shell–corona micelles from a polyether-based triblock terpolymer: Investigation of the pH-dependent micellar structureExternal link Langmuir 2018 , 34 , 7813-7820.
C. Guerrero‐Sanchez, J. Zhang, J. Vitz, U. S. SchubertHigh-throughput synthesis of polymersExternal link in Encyclopedia of Polymer Science and Technology , 2018 , doi:10.1002/0471440264.pst0471440668.
2017
A. T. Press, A. Ramoji, M. vd Lühe, A. C. Rinkenauer, J. Hoff, M. Butans, C. Rössel, C. Pietsch, U. Neugebauer, F. H. Schacher, M. BauerCargocarrier interactions significantly contribute to micellar conformation and biodistributionExternal link NPG Asia Materials 2017 , 9 , e444.
M. Pröhl, S. Seupel, P. Sungur, S. Höppener, M. Gottschaldt, J. C. Brendel, U. S. SchubertThe influence of the grafting density of glycopolymers on the lectin binding affinity of block copolymer micellesExternal link Polymer 2017 , 133 , 205-212.
I. Perevyazko, A. S. Gubarev, L. Tauhardt, A. Dobrodumov, G. M. Pavlov, U. S. SchubertLinear poly(ethylene imine)s: true molar masses, solution properties and conformationExternal link Polym. Chem. 2017 , 8 , 7169-7179.
R. Heintzmann, T. HuserSuper-resolution structured illumination microscopyExternal link Chem. Rev. 2017 , 117 , 13890-13908.