Chemikerin im Labor

T01

Targeting renal phosphoinositide 3-kinase γ (PI3Kγ) by dye-tagged nanoparticles
Chemikerin im Labor
Image: Marina Romanova/FSU Jena

To exploit the therapeutic potential of PI3K inhibition during the hemolytic-uremic syndrome (HUS), a compartmentalized delivery strategy of kinase-inhibitors (such as AS605240) to the kidney seems promising to allow avoiding off-target effects, e. g. on systemic immune functionality. We aim to design functionalized nanoparticles that rely on modification of polymers with dyes that may act as targeting ligands for organic anion transporters that confer compartmentalized delivery to the kidney. In vitro effects of the dye-tagged particles loaded with the inhibitor AS605240 will be examined in human microvascular endothelial cells under physiological and pathophysiological conditions to detect mechanisms and key features conferring cell damage and prevention. The in vivo performance of the biocompatible nanoformulated PI3K inhibitors will be evaluated with respect to their enrichment and compartmentalization in the kidneys applying comprehensive biophotonic strategies.

Grafik Projekt T01 Grafik Projekt T01 Graphic: Coldewey/Bauer/Schubert

Principle investigators

Prof. Dr. med. Sina M. Coldewey Prof. Dr. med. Sina M. Coldewey Image: Michael Szabó/UKJ

Prof. Dr. med. Sina M. Coldewey

Department of Anaesthesiology and Intensive Care Medicine
Jena University Hospital
Junior research group Translational Septomics, ZIK Septomics
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323101
sina.coldewey@med.uni-jena.de

Prof. Dr. Michael Bauer Prof. Dr. Michael Bauer Image: Prof. Dr. Michael Bauer

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de

Prof. Dr. Ulrich S. Schubert Prof. Dr. Ulrich S. Schubert Image: Anne Günther (University of Jena)

Prof. Dr. Ulrich S. Schubert

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de

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