test tubes containing pink fuid

D01

Mimicking viral entry mechanisms with polymeric nanoparticles
test tubes containing pink fuid
Image: Jan-Peter Kasper (University of Jena)

Polymer-based nanoparticles are a promising approach for drug formulation. The modification of their surface also allows tissue- and cell-type-specific accumulation and could help to avoid adverse effects. Coronaviruses, such as SARS-CoV2, have special surface structures (spike proteins) to dock to and infect their target cells in the human organism. Since effective drug therapies for coronaviruses are still rare, this project deals with the creation of a toolbox for the preparation of drug loaded virus-like nanoparticles with the potential of an easy adoption to different viruses. The aim is to deliver the anti-viral drugs specifically into potentially virus-infected cells and tissue to fight future pandemic incidences fast and efficiently. Spike proteins will be used as targeting moiety on the virus-like nanoparticles and their uptake mechanism will be compared to wild-type and non-infectious virus-like particles, both for human SARS-CoV-2 in cell systems and murine hepatitis coronavirus in organisms.

Grafik Projekt D01 Grafik Projekt D01 Graphic: Stephanie Schubert

Principle investigators

Prof. Dr. Christian Eggeling Prof. Dr. Christian Eggeling Image: Anne Günther (University of Jena)

Prof. Dr. Christian Eggeling

Institute for Applied Optics and Biophysics
Friedrich Schiller University Jena
Helmholtzweg 4
07743 Jena
Phone: +49 3641 9-47670
christian.eggeling@uni-jena.de

Prof. Dr. Michael Bauer Prof. Dr. Michael Bauer Image: Prof. Dr. Michael Bauer

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de

Prof. Dr. Ulrich S. Schubert Prof. Dr. Ulrich S. Schubert Image: Anne Günther (University of Jena)

Prof. Dr. Ulrich S. Schubert

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de

Staff

Daniel Schröder

Institute for Applied Optics and Biophysics
Faculty of Physics and Astronomy
Friedrich Schiller University Jena
Max-Wien Platz 1, 07743 Jena
daniel.schroeder@uni-jena.de

Wanling Foo

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
wanling.foo@med.uni-jena.de

Mitali Sonawane

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
mitali.sonawane@med.uni-jena.de

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