C06
Prevention of late phase liver damage by targeted modulation of the liver’s immune response
Chemiker mit Reagenzglas im Labor
The liver plays a central role in the pathogenesis of live-threatening sepsis. Cross talk between parenchymal and immune cells, primarily tissue-resident macrophages (Kupffer cells) and infiltrating neutrophils has long been recognized as a key event in infection-driven liver dysfunction. Aims of this project comprise the investigation of the dynamic immune cell composition in sepsis and the inhibition of the recruitment of inflammatory cells. Using advanced lineage tracing technologies targeting specific macrophage populations, the ontogenetical and functional heterogeneity of liver macrophages in steady state and sepsis will be unraveled. Novel tailor-made biodegradable nanoparticles targeting hepatocytes and macrophages will allow the modification of chemotactic factors like Cxcl-2 by CRISPR/Cas.
Prof. Dr. Claudia Waskow
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstrasse 11
07745 Jena
Phone: +49 3641 646 707
claudia.waskow@leibniz-fli.de
Prof. Dr. Michael Bauer
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de
Prof. Dr. Ulrich S. Schubert
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de
Stavroula Litsiou
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstrasse 11
07745 Jena
Stavroula.Litsiou@leibniz-fli.de
Michael Streiber
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48575
michael.streiber@uni-jena.de
Na Liu
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
na.liu@med.uni-jena.de