Chemiker mit Reagenzglas im Labor

C06

Prevention of late phase liver damage by targeted modulation of the liver’s immune response
Chemiker mit Reagenzglas im Labor
Image: Marina Romanova/FSU Jena

The liver plays a central role in the pathogenesis of live-threatening sepsis. Cross talk between parenchymal and immune cells, primarily tissue-resident macrophages (Kupffer cells) and infiltrating neutrophils has long been recognized as a key event in infection-driven liver dysfunction. Aims of this project comprise the investigation of the dynamic immune cell composition in sepsis and the inhibition of the recruitment of inflammatory cells. Using advanced lineage tracing technologies targeting specific macrophage populations, the ontogenetical and functional heterogeneity of liver macrophages in steady state and sepsis will be unraveled. Novel tailor-made biodegradable nanoparticles targeting hepatocytes and macrophages will allow the modification of chemotactic factors like Cxcl-2 by CRISPR/Cas.

Grafik Projekt C06 Grafik Projekt C06 Graphic: C. Waskow

Principle investigators

Prof. Dr. Claudia Waskow Prof. Dr. Claudia Waskow Image: Prof. Dr. Claudia Waskow

Prof. Dr. Claudia Waskow

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstrasse 11
07745 Jena
Phone: +49 3641 646 707
claudia.waskow@leibniz-fli.de 

Prof. Dr. Michael Bauer Prof. Dr. Michael Bauer Image: Prof. Dr. Michael Bauer

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de

Prof. Dr. Ulrich S. Schubert Prof. Dr. Ulrich S. Schubert Image: Anne Günther (University of Jena)

Prof. Dr. Ulrich S. Schubert

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de

Staff

Dr. Stephan Culemann

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstrasse 11
07745 Jena
Phone: +49 3641 656 706
stephan.culemann@leibniz-fli.de 

Stavroula Litsiou Stavroula Litsiou Image: Stavroula Litsiou

Stavroula Litsiou

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstrasse 11
07745 Jena
Stavroula.Litsiou@leibniz-fli.de

Na Liu

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
na.liu@med.uni-jena.de

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