Two female chemists working on an electron microscope.

C04

Investigation of cellular response to nanoparticle uptake by dual TEM and superresolution fluorescence imaging
Two female chemists working on an electron microscope.

C04 investigates the internalisation of nanoparticles into cells and tissue and their association to intracellular compartments and their interactions with membranes. For this purpose, a combination of electron microscopy and high-resolution fluorescence microscopy techniques are utilised. Co-localisation of inflammatory markers, enzymes and receptors in the cellular context in response of particle uptake and drug release is used to obtain a deeper inside into the mode of action of nanoparticle formulations in the biological context.

graphical abstract C04 graphical abstract C04 Image: S. Hoeppener

Principle investigators

PD. Dr. Stephanie Höppener PD. Dr. Stephanie Höppener Image: Anne Günther (University of Jena)

PD. Dr. Stephanie Höppener

Electron Microscopy Group (EMG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller Unviversity Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48596
s.hoeppener@uni-jena.de

Prof. Dr. Rainer Heintzmann Prof. Dr. Rainer Heintzmann Image: Prof. Dr. Rainer Heintzmann

Prof. Dr. Rainer Heintzmann

Institute for Physical Chemistry (IPC)
Friedrich Schiller Unviversity Jena
Helmholtzweg 4
07745 Jena
Phone: +49 3641 9-48350
rainer.heintzmann@uni-jena.de

Staff

Fengjiao Ma

Institute for Physical Chemistry (IPC)
Friedrich Schiller Unviversity Jena
Helmholtzweg 4
07745 Jena
Phone: +49 3641 9-48350
fengjiao.ma@leibniz-ipht.de

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