C02
Tailored delivery of anti-inflammatory natural drugs using polymer-based nanocarriers to prevent cytokine and eicosanoid storms in infectious inflammation
test tubes containing pink fuid
Anti-inflammatory drugs (novel 6BIGOE derivatives, AKBA, kadsurenin F, dexamethason) will be evaluated for interfering with cytokine and eicosanoid storms in infectious inflammation such as sepsis and Covid-19. They will be encapsulated under the application of new sustainable techniques in polymers with different stealth moieties and specific targeting strategies for the treatment of M1/M2 macrophages and SARS-CoV-2-infected epithelial cells. Using microfluidic biochips, a shell-less hen´s egg and a murine peritonitis model, the influence of environmental factors will be evaluated.
Prof. Dr. Dagmar Fischer
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstraße 4 (Haus 6)
91058 Erlangen
Phone: +49 9131 85-29552
dagmar.fischer@fau.de
Prof. Dr. Oliver Werz
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801
oliver.werz@uni-jena.de
Vivien Bachmann
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
vivien.bachmann@uni-jena.de
Jan Westhoff
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstraße 4 (Haus 6)
91058 Erlangen
jan.westhoff@fau.de