Anti-inflammatory drugs (novel 6BIGOE derivatives, AKBA, kadsurenin F, dexamethason) will be evaluated for interfering with cytokine and eicosanoid storms in infectious inflammation such as sepsis and Covid-19. They will be encapsulated under the application of new sustainable techniques in polymers with different stealth moieties and specific targeting strategies for the treatment of M1/M2 macrophages and SARS-CoV-2-infected epithelial cells. Using microfluidic biochips, a shell-less hen´s egg and a murine peritonitis model, the influence of environmental factors will be evaluated.
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Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstr. 6 (Haus 4)
91058 Erlangen
Phone: +49 9131 85-29552
dagmar.fischer@fau.de
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801
oliver.werz@uni-jena.de
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49616
anna.czapka@uni-jena.de
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstr. 6 (Haus 4)
91058 Erlangen
jan.westhoff@fau.de
