Dextran derivatives and polyesters are synthesized and used as carrier materials for inhibitors that target inflammatory pathways in hepatic stellate cells to slow down the development of liver fibrosis. Advanced biophotonic imaging is utilized to characterize the inhibitor-loaded nanoparticles in cells or directly in the liver. The nanoparticle induced modulation and activation of stellate cells are also analyzed through omics-methods. These joint efforts allow for novel approaches to therapeutically target hepatic stellate cells.
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Institute for Physical Chemistry (IPC)
Friedrich Schiller Unviversity of Jena
Helmholtzweg 4
07743 Jena
Phone: +49 3641 9-48320
juergen.popp@uni-jena.de
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Lessingstrasse 8
07743 Jena
Phone: +49 3641 9-48599
stephanie.schubert@uni-jena.de
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Forschungszentrum Lobeda (FZL)
Erlanger Allee 101
07747 Jena
Klea.Mehmetaj@med.uni-jena.de
