58/5000 A technician working on a centrifuge.

C01

Biophotonic characterisation of the interaction of nanoparticles and drugs with hepatic stellate cells
58/5000 A technician working on a centrifuge.

Dextran derivatives and polyesters are synthesized and used as carrier materials for inhibitors that target inflammatory pathways in hepatic stellate cells to slow down the development of liver fibrosis. Advanced biophotonic imaging is utilized to characterize the inhibitor-loaded nanoparticles in cells or directly in the liver. The nanoparticle induced modulation and activation of stellate cells are also analyzed through omics-methods. These joint efforts allow for novel approaches to therapeutically target hepatic stellate cells.

Grafik Projekt C01 Grafik Projekt C01 Graphic: S. Schubert

Principle investigators

Prof. Dr. Jürgen Popp Prof. Dr. Jürgen Popp Image: Prof. Dr. Jürgen Popp

Prof. Dr. Jürgen Popp

Institute for Physical Chemistry (IPC)
Friedrich Schiller Unviversity of Jena
Helmholtzweg 4
07743 Jena
Phone: +49 3641 9-48320
juergen.popp@uni-jena.de

Dr. Stephanie Schubert Dr. Stephanie Schubert Image: Dr. Stephanie Schubert

Dr. Stephanie Schubert

Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Lessingstrasse 8
07743 Jena
Phone: +49 3641 9-48599
stephanie.schubert@uni-jena.de

Prof. Dr. Michael Bauer Prof. Dr. Michael Bauer Image: Prof. Dr. Michael Bauer

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Clinic for Anaesthesiology and Intensive Care Medicine
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323100
michael.bauer@med.uni-jena.de

Staff

Mira Behnke

Center for Applied Research (ZAF)
Friedrich Schiller University Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48575
mira.behnke@uni-jena.de

Klea Mehmetaj Klea Mehmetaj Image: Roman Moebius

Klea Mehmetaj

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Forschungszentrum Lobeda (FZL)
Erlanger Allee 101
07747 Jena
Klea.Mehmetaj@med.uni-jena.de

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