Raman spectroscopic characterization of the linkage- and interaction mechanism of nanoparticles and drugs with hepatic stellate cells
58/5000 A technician working on a centrifuge.
The chemical sensitivity of linear and non-linear Raman-based imaging approaches will be utilized for the characterization of the interaction mechanism of nanoparticles and drugs with (i) hepatic stellate cells (HepSC) and (ii) their uptake kinetics, aggregation behavior, and vitamin A (vit. A) release within the cells. The specific role of HepSC in vit. A uptake and storage offers the ability to purposefully use this function as a targeting moiety at least in early stages of their transformation. Therefore, natural and synthetic polymers will be covalently functionalized with vit. A as targeting moiety for HepSC uptake to be further formulated into siRNA carrying nanoparticular systems for HepSC treatment.
Image: S. Schubert
Prof. Dr. Jürgen Popp
Institute for Physical Chemistry (IPC) Friedrich Schiller Unviversity of Jena Helmholtzweg 4 07743 Jena Phone: +49 3641 9-48320 email@example.com
Center for Sepsis Control and Care (CSCC) University Hospital Jena (UKJ) Clinic for Anaesthesiology and Intensive Care Medicine Am Klinikum 1 07747 Jena Phone: +49 3641 9-323100 firstname.lastname@example.org
Marko Rodewald Institute of Physical Chemistry (IPC) Helmholtzweg 4, 07743 Jena Phone: +49 3641 9-48954 email@example.com
Paul Klemm Center for Applied Research (ZAF) Philosophenweg 7, 07743 Jena Phone: +49 3641 9-48580 firstname.lastname@example.org
Mira Behnke Center for Applied Research (ZAF) Philosophenweg 7, 07743 Jena Phone: +49 3641 9-48575 email@example.com
Sophie Huschke Center for Sepsis Control and Care (CSCC) University Hospital Jena (UKJ) Forschungszentrum Lobeda (FZL) Erlanger Allee 101, 07747 Jena Phone: +49 3641 9-323238 firstname.lastname@example.org