Project B03 will focus on the synthesis of high performing carriers like guanidinium containing terpolymers where systematic control of the hydrophilic-hydrophobic balance will be utilized to create safe and efficient carriers for nucleic acids. The terpolymers will be formulated with nucleic acids where the resulting polyplexes will be applied as anti-inflammatory treatment based on NF-kB knockdown which will be tested in cell culture systems like endothelial cells or epithelial intestinal models and M1/M2 macrophages.
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Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Lessingstraße 8
07743 Jena
Phone: +49 3641 9-48790
kalina.peneva@uni-jena.de
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstr. 6 (Haus 4)
91058 Erlangen
Phone: +49 9131 85-29552
dagmar.fischer@fau.de
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstr. 6 (Haus 4)
91058 Erlangen
jan.egger@fau.de
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
markus.koetzsche@uni-jena.de
