test tubes containing pink fuid


Guanidinium-containing nanoparticles for gene delivery
test tubes containing pink fuid

Project B03 will prepare tailor-made polyplexes consisting of guanidinium group-bearing polydepsipeptides and DNA / siRNA (nuclear factor kappa B-decoys and -siRNA (RelA)) that can be applied for the treatment of inflammation related diseases. The characteristics of the polymers will be systematically altered to reach the maximum transfection efficacy in inflammatory vascular endothelial lesions, which will be studied using (i) static models, (ii) dynamic fluidic systems and (iii) in vivo models of the chick area vasculosa of hen eggs. A special focus will be placed on the influence of the protein corona and the blood flow on the performance of the polymers.

graphical abstract B03 Image: K. Peneva

Principle investigators:

Prof. Dr. Kalina Peneva

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Lessingstraße 8
07743 Jena
Phone: +49 3641 9-48790

Prof. Dr. Dagmar Fischer

Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstr. 6 (Haus 4)
91058 Erlangen
Phone: +49 9131 85-29552


Franz Hack
Institut of Pharmacy (IP)
Helmholzweg 4, 07743 Jena
Phone: +49 3641 9-49950

Ceren Cocka
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48793


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