B02
Macromolecular prodrug nanoparticles for antimicrobial therapy
A female and a male chemist working in the synthesis lab.
B02 develops strategies to target intracellular compartments that are used by pathogenic microorganisms to escape from the immune system and are difficult to be reached by antibiotics. B02 engineers polymer nanoparticles (NPs) with targeting surfaces that allow efficient uptake by macrophages. The NPs contain antimycotics that are specifically released in phagolysosomes (PLs). A compound that enhances fusion of PLs containing pathogens with PLs containing antimycotic NPs will be developed for improving therapies.
Prof. Dr. Axel A. Brakhage
Leibniz Institute for Natural Product Research & Infection Biology
Hans Knöll Institute (HKI)
Beutenbergstraße 11a
07745 Jena
Phone: +49 3641 532 1001
axel.brakhage@leibniz-hki.de
Dr. Carlos Guerrero-Sanchez
High-throughput Experimentation Group (HTG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller University Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48598
carlos.guerrero.sanchez@uni-jena.de
Katherine Gonzalez Rojas
Leibniz Institute for Natural Product Research & Infection Biology
Hans Knöll Institute (HKI)
Beutenbergstraße 11a
07745 Jena
Phone: +49 3641 532 1731
katherine.gonzalez@leibniz-hki.de
Julien Alex
High-throughput Experimentation Group (HTG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller University Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48580
julien.alex@uni-jena.de