test tubes containing pink fuid


Dual inhibitors of prostaglandin E2 syn¬thase-1 and 5-lipoxygenase as anti-inflammatory payloads in nanoparticles
test tubes containing pink fuid

We will study dual inhibitors of 5-lipoxygenase (or FLAP) and microsomal prostaglandin E2 synthase (mPGES)-1 that may display better anti-inflammatory efficacy and lower risks of side effects versus non-steroidal anti inflammatory drugs (NSAIDs). As these dual inhibitors are acidic lipophilic molecules with strong tendency for plasma protein binding, encapsulation into hydrophobic polymer libraries (polyesters, polyketals or dextran acetals) by diverse encapsulation methods may improve their bioavailability and efficacy. We will also design targeted nanoparticles as some immune cells show excellent uptake thereof.

graphical abstract A04 Image: O. Werz

Principle investigators:

Prof. Dr. Oliver Werz

Institute of Pharmacy (IP)
Friedrich Schiller University of Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801

Prof. Dr. Ulrich S. Schubert

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200


Christian Kretzer
Institute of Pharmacy (IP)
Philosophenweg 14, 07743 Jena
Phone: +49 3641 9-49818

Blerina Shkodra-Pula
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48599


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