Dual inhibitors of prostaglandin E2 syn¬thase-1 and 5-lipoxygenase as anti-inflammatory payloads in nanoparticles
test tubes containing pink fuid
We will study dual inhibitors of 5-lipoxygenase (or FLAP) and microsomal prostaglandin E2 synthase (mPGES)-1 that may display better anti-inflammatory efficacy and lower risks of side effects versus non-steroidal anti inflammatory drugs (NSAIDs). As these dual inhibitors are acidic lipophilic molecules with strong tendency for plasma protein binding, encapsulation into hydrophobic polymer libraries (polyesters, polyketals or dextran acetals) by diverse encapsulation methods may improve their bioavailability and efficacy. We will also design targeted nanoparticles as some immune cells show excellent uptake thereof.
Image: O. Werz
Prof. Dr. Oliver Werz
Institute of Pharmacy (IP) Friedrich Schiller University of Jena Philosophenweg 14 07743 Jena Phone: +49 3641 9-49801 firstname.lastname@example.org
Prof. Dr. Ulrich S. Schubert
Laboratory of Organic and Macromolecular Chemistry (IOMC) Friedrich Schiller University of Jena Humboldtstraße 10 07743 Jena Phone: +49 3641 9-48200 email@example.com