Eine Chemikerin und ein Chemiker arbeiten im Syntheselabor.


Tailored nanoparticles with two-step release pattern: New tool for drug delivery
A female and a male chemist working in the synthesis lab.

Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. These features will be exploited to prepare a matrix for deacetylase inhibitors (HDACi). Since protein acetylation significantly affects regulation of the immune system, HDACi could potentially be useful for the treatment of inflammation and septic shock. Consequently, our goal is to tailor a polysaccharide-based matrix as a controlled release system for HDACi by studying structure-property-relations of polysaccharide esters.

Grafische Zusammenfassung A02 Image: A. Koschella

Principle investigators:

Prof. Dr. Thomas Heinze

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48270

Prof. Dr. Thorsten Heinzel

Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University of Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49350


Henry Lindemann
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48266

Susanne Hofmann
Institute of Biochemistry and Biophysics (IBB)
Hans-Knöll-Straße 2, 07745 Jena
Phone: +49 3641 9-49356



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