Tailored nanoparticles with two-step release pattern: New tool for drug delivery
A female and a male chemist working in the synthesis lab.
Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. These features will be exploited to prepare a matrix for deacetylase inhibitors (HDACi). Since protein acetylation significantly affects regulation of the immune system, HDACi could potentially be useful for the treatment of inflammation and septic shock. Consequently, our goal is to tailor a polysaccharide-based matrix as a controlled release system for HDACi by studying structure-property-relations of polysaccharide esters.
Image: A. Koschella
Prof. Dr. Thomas Heinze
Laboratory of Organic and Macromolecular Chemistry (IOMC) Friedrich Schiller University of Jena Humboldtstraße 10 07743 Jena Phone: +49 3641 9-48270 firstname.lastname@example.org
Prof. Dr. Thorsten Heinzel
Institute of Biochemistry and Biophysics (IBB) Friedrich Schiller University of Jena Hans-Knöll-Straße 2 07745 Jena Phone: +49 3641 9-49350 email@example.com
Henry Lindemann Laboratory of Organic and Macromolecular Chemistry (IOMC) Humboldtstraße 10, 07743 Jena Phone: +49 3641 9-48266 firstname.lastname@example.org
Susanne Hofmann Institute of Biochemistry and Biophysics (IBB) Hans-Knöll-Straße 2, 07745 Jena Phone: +49 3641 9-49356 email@example.com