A female and a male chemist working in the synthesis lab.

A02

Multifunctional nanoparticles based on polysaccharides for targeted drug delivery with two-step release behavior
A female and a male chemist working in the synthesis lab.

Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. Since protein acetylation significantly affects regulation of the immune system, deacetylase inhibitors (HDACi) could be useful for the treatment of inflammatory diseases and life-threatening syndromes induced by infections, such as sepsis or hemolytic-uremic syndrome. We developed biocompatible and functional polysaccharide-based drug-loaded nanoparticles, which will be further modified to achieve tissue-specificity for anti-inflammatory and tissue protective compounds suitable for clinical translation in inflammatory diseases.

Grafik Projekt A02 Grafik Projekt A02 Graphic: Coldewey/Heinzel/Heinze

Principle investigators

Prof. Dr. Thomas Heinze Prof. Dr. Thomas Heinze Image: Anne Günther (University of Jena)

Prof. Dr. Thomas Heinze

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48270
thomas.heinze@uni-jena.de

Prof. Dr. med. Sina M. Coldewey Prof. Dr. med. Sina M. Coldewey Image: Michael Szabó/UKJ

Prof. Dr. med. Sina M. Coldewey

Department of Anaesthesiology and Intensive Care Medicine
Jena University Hospital
Junior research group Translational Septomics, ZIK Septomics
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323101
sina.coldewey@med.uni-jena.de

Prof. Dr. Thorsten Heinzel Prof. Dr. Thorsten Heinzel Image: Prof. Dr. Thorsten Heinzel

Prof. Dr. Thorsten Heinzel

Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49350
t.heinzel@uni-jena.de

Projektteam

Henry Lindemann Henry Lindemann Image: Henry Lindemann

Henry Lindemann

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48266
henry.lindemann@uni-jena.de

Jamila Wegener Jamila Wegener Image: Michael Szabo, UKJ

Jamila Wegener

Department of Anaesthesiology and Intensive Care Medicine
Jena University Hospital
Junior research group Translational Septomics, ZIK Septomics
Albert-Einstein-Str. 10
07745 Jena
Phone: +49 3641 9-323259
jamila.wegener@med.uni-jena.de

 

Marie Kühne Marie Kühne Image: Anne Günther (University of Jena)

Marie Kühne

Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49354
marie.kuehne@uni-jena.de 

Share this page
Friedrich Schiller University on social media:
Studying amid excellence:
Top of the page