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Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. Since protein acetylation significantly affects regulation of the immune system, deacetylase inhibitors (HDACi) could be useful for the treatment of inflammatory diseases and life-threatening syndromes induced by infections, such as sepsis or hemolytic-uremic syndrome. We developed biocompatible and functional polysaccharide-based drug-loaded nanoparticles, which will be further modified to achieve tissue-specificity for anti-inflammatory and tissue protective compounds suitable for clinical translation in inflammatory diseases.
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Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48270
thomas.heinze@uni-jena.de
Department of Anaesthesiology and Intensive Care Medicine
Jena University Hospital
Junior research group Translational Septomics, ZIK Septomics
Am Klinikum 1
07747 Jena
Phone: +49 3641 9-323101
sina.coldewey@med.uni-jena.de
Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49350
t.heinzel@uni-jena.de
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48266
henry.lindemann@uni-jena.de
Department of Anaesthesiology and Intensive Care Medicine
Jena University Hospital
Junior research group Translational Septomics, ZIK Septomics
Albert-Einstein-Str. 10
07745 Jena
Phone: +49 3641 9-323259
jamila.wegener@med.uni-jena.de
Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49354
marie.kuehne@uni-jena.de
