Ein Chemiker arbeitet mit flüssigem Stickstoff.


Tailor-made multifunctional polymers and nanoparticles with optimized compatibility between biodegradable core and encapsulated drug
A chemist works with liquid nitrogen.

The goal of the project is to develop methods that allow tailoring of a polymeric nanoparticulate material to provide maximum drug loading and release efficiency by a combined experimental and computational approach. For this, hydrophobic polymers (polyketals, poly(ester amide)s) will be systematically altered by variation of the respective monomers and introduction of hydrophilic blocks based on poly(2-oxazoline)s. To develop polymers tailored for the maximum efficiency of drug encapsulation, the synthetic part will be guided by computational studies on the relationship between the structures of the polymers and their thermodynamic compatibility with model compounds and selected drugs.

Grafische Zusammenfassung A01 Image: C. Weber, M. Sierka

Principle investigators:

Prof. Dr. Ulrich S. Schubert

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200

Prof. Dr. Marek Sierka

Otto  Schott Institute of Materials Research (OSIM)
Friedrich Schiller University of Jena
Löbdergraben 32
07743 Jena
Phone: +49 3641 9-47930


Irina Muljajew
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48581

Mingzhe Chi
Otto  Schott Institute of Materials Research (OSIM)
Löbdergraben 32, 07743 Jena
Phone: +49 3641 9-47785

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