Tailor-made multifunctional polymers and nanoparticles with optimized compatibility between biodegradable core and encapsulated drug
A chemist works with liquid nitrogen.
The goal of the project is to develop methods that allow tailoring of a polymeric nanoparticulate material to provide maximum drug loading and release efficiency by a combined experimental and computational approach. For this, hydrophobic polymers (polyketals, poly(ester amide)s) will be systematically altered by variation of the respective monomers and introduction of hydrophilic blocks based on poly(2-oxazoline)s. To develop polymers tailored for the maximum efficiency of drug encapsulation, the synthetic part will be guided by computational studies on the relationship between the structures of the polymers and their thermodynamic compatibility with model compounds and selected drugs.
Image: C. Weber, M. Sierka
Prof. Dr. Ulrich S. Schubert
Laboratory of Organic and Macromolecular Chemistry (IOMC) Friedrich Schiller University of Jena Humboldtstraße 10 07743 Jena Phone: +49 3641 9-48200 email@example.com
Prof. Dr. Marek Sierka
Otto Schott Institute of Materials Research (OSIM) Friedrich Schiller University of Jena Löbdergraben 32 07743 Jena Phone: +49 3641 9-47930 firstname.lastname@example.org
Irina Muljajew Laboratory of Organic and Macromolecular Chemistry (IOMC) Humboldtstraße 10, 07743 Jena Phone: +49 3641 9-48581 email@example.com
Mingzhe Chi Otto Schott Institute of Materials Research (OSIM) Löbdergraben 32, 07743 Jena Phone: +49 3641 9-47785 firstname.lastname@example.org