58/5000 A technician working on a centrifuge.

C01

Raman spectroscopic characterization of the linkage- and interaction mechanism of nanoparticles and drugs with hepatic stellate cells
58/5000 A technician working on a centrifuge.

The chemical sensitivity of linear and non-linear Raman-based imaging approaches will be utilized for the characterization of the interaction mechanism of nanoparticles and drugs with (i) hepatic stellate cells (HepSC) and (ii) their uptake kinetics, aggregation behavior, and vitamin A (vit. A) release within the cells. The specific role of HepSC in vit. A uptake and storage offers the ability to purposefully use this function as a targeting moiety at least in early stages of their transformation. Therefore, natural and synthetic polymers will be covalently functionalized with vit. A as targeting moiety for HepSC uptake to be further formulated into siRNA carrying nanoparticular systems for HepSC treatment.

graphical abstract C01 Image: S. Schubert

Principle investigators:

Prof. Dr. Jürgen Popp

Institute for Physical Chemistry (IPC)
Friedrich Schiller Unviversity of Jena
Helmholtzweg 4
07743 Jena
Phone: +49 3641 9-48320
juergen.popp@uni-jena.de

Dr. Stephanie Schubert

Institute of Pharmacy (IP)
Friedrich Schiller University of Jena
Lessingstrasse 8
07743 Jena
Phone: +49 3641 9-48599
stephanie.schubert@uni-jena.de

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Erlanger Allee 101
07747 Jena
Phone: +49 3641 9-323110
michael.bauer@med.uni-jena.de

Staff:

Marko Rodewald
Institute of Physical Chemistry (IPC)
Helmholtzweg 4, 07743 Jena
Phone: +49 3641 9-48954
marko.rodewald@uni-jena.de

Paul Klemm
Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48580
paul.klemm@uni-jena.de

Sophie Huschke
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Erlanger Allee 101, 07747 Jena
Phone: +49 3641 9-323110
sophie.huschke@uni-jena.de

 

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