test tubes containing pink fuid

B03

Guanidinium-containing nanoparticles for gene delivery
test tubes containing pink fuid

Project B03 will prepare tailor-made polyplexes consisting of guanidinium group-bearing polydepsipeptides and DNA / siRNA (nuclear factor kappa B-decoys and -siRNA (RelA)) that can be applied for the treatment of inflammation related diseases. The characteristics of the polymers will be systematically altered to reach the maximum transfection efficacy in inflammatory vascular endothelial lesions, which will be studied using (i) static models, (ii) dynamic fluidic systems and (iii) in vivo models of the chick area vasculosa of hen eggs. A special focus will be placed on the influence of the protein corona and the blood flow on the performance of the polymers.

graphical abstract B03 Image: K. Peneva

Principle investigators:

Prof. Dr. Kalina Peneva

Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Lessingstraße 8
07743 Jena
Phone: +49 3641 9-48790
kalina.peneva@uni-jena.de

Prof. Dr. Dagmar Fischer

Institut of Pharmacy (IP)
Friedrich Schiller University of Jena
Lessingstrasse 8
07743 Jena
Phone: +49 3641 9-49941
dagmar.fischer@uni-jena.de

Staff:

Andrew Njau
Institut of Pharmacy (IP)
Helmholzweg 4, 07743 Jena
Phone: +49 3641 9-49950
andrew.njau@uni-jena.de

Ceren Cocka
Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48793
ceren.cocka@uni-jena.de

 

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