A female and a male chemist working in the synthesis lab.

B02

Macromolecular prodrug nanoparticles for antimicrobial therapy
A female and a male chemist working in the synthesis lab.

The project will develop macrophage-targeting nanoparticles containing phagolysosome-specific macromolecular prodrugs. Macromolecular prodrugs bearing novel antibacterial and antifungal compounds will be synthesized and formulated to particles together with mannose-functionalized polymers. It will be studied if these nanoparticles are suitable to transport antibiotics across two cell membranes and release them at specific sites. This may open entirely novel therapeutic approaches, including the development of novel antibiotics.

graphical abstract B02 Image: T. Heinekamp

Principle investigators:

Prof. Dr. Axel A. Brakhage

Leibniz Institute for Natural Product Research & Infection Biology
Hans Knöll Institute (HKI)
Beutenbergstraße 11a
07745 Jena
Phone: +49 3641 532 1001
axel.brakhage@leibniz-hki.de

Dr. Carlos Guerrero-Sanchez

High-throughput Experimentation Group (HTG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller University of Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48598
carlos.guerrero.sanchez@uni-jena.de

Staff:

Katherine Gonzalez Rojas
Leibniz Institute for Natural Product Research & Infection Biology
Hans Knöll Institute (HKI)
Beutenbergstraße 11a, 07745 Jena
Phone: +49 3641 532 1731
katherine.gonzalez@leibniz-hki.de

Alex, Julien
High-throughput Experimentation Group (HTG)
Jena Center for Soft Matter (JCSM)
Philosophenweg 7, 07743 Jena
Phone: +49 3641 9-48580
julien.alex@uni-jena.de

 

 

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