A chemist uses a pipette to introduce cell samples into a so-called microtiter plate.

A05

Targetable nanoparticles for efficient translocation across gastrointestinal barriers
A chemist uses a pipette to introduce cell samples into a so-called microtiter plate.

Based on a systematic platform we will generate polymeric nanoparticles, which effectively translocate across gastrointestinal barriers and target macrophages as main pro-inflammatory cells within the mucosa. For this purpose, polymer nanoparticles of different size and, in particular, of controlled anisotropic shape are modified with targeting ligands to enhance translocation efficacy and to maximize the adherence as well as uptake into the desired cells. The nanosized diameter guarantees an efficient translocation through mucus and epithelium, while the increased lengths and surface area favors the adhesion to the macrophages in mucosal layer.

graphical absract A05 Image: J. C. Brendel

Principle investigators:

Prof. Dr. Andreas Stallmach

Clinic of Internal Medicine IV
University Hospital Jena
Am Klinikum 1
07740 Jena
Phone: +49 3641 9-324221
andreas.stallmach@med.uni-jena.de

Dr. Johannes C. Brendel

Advanced Polymer Synthesis Group (APG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller University of Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48989
johannes.brendel@uni-jena.de

Staff:

Elena Gardey
Clinic of Internal Medicine IV
University Hospital Jena
Am Klinikum 1, 07740 Jena
Phone: +49 3641 9-324404
elena.gardey@med.uni-jena.de

Fabian Sobotta
Jena Center for Soft Matter (JCSM)
Philosophenweg 7, 07743 Jena
Phone: +49 3641 9-48239
fabian.sobotta@uni-jena.de

 

 

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