A female and a male chemist working in the synthesis lab.

A02

Tailored nanoparticles with two-step release pattern: New tool for drug delivery
A female and a male chemist working in the synthesis lab.

Polysaccharide-based nanoparticles are suitable drug carriers, which can be widely modified in terms of structures and properties. These features will be exploited to prepare a matrix for deacetylase inhibitors (HDACi). Since protein acetylation significantly affects regulation of the immune system, HDACi could potentially be useful for the treatment of inflammation and septic shock. Consequently, our goal is to tailor a polysaccharide-based matrix as a controlled release system for HDACi by studying structure-property-relations of polysaccharide esters.

graphical abstract A02 Image: A. Koschella

Principle investigators:

Prof. Dr. Thomas Heinze

Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48270
thomas.heinze@uni-jena.de

Prof. Dr. Thorsten Heinzel

Institute of Biochemistry and Biophysics (IBB)
Friedrich Schiller University of Jena
Hans-Knöll-Straße 2
07745 Jena
Phone: +49 3641 9-49350
t.heinzel@uni-jena.de

Staff:

Henry Lindemann
Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48266
henry.lindemann@uni-jena.de

Susanne Hofmann
Institute of Biochemistry and Biophysics (IBB)
Hans-Knöll-Straße 2, 07745 Jena
Phone: +49 3641 9-49356
susanne.hofmann@uni-jena.de

 

 

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