A chemist works with liquid nitrogen.

A01

Tailor-made multifunctional polymers and nanoparticles with optimized compatibility between biodegradable core and encapsulated drug
A chemist works with liquid nitrogen.

The goal of the project is to develop methods that allow tailoring of a polymeric nanoparticulate material to provide maximum drug loading and release efficiency by a combined experimental and computational approach. For this, hydrophobic polymers (polyketals, poly(ester amide)s) will be systematically altered by variation of the respective monomers and introduction of hydrophilic blocks based on poly(2-oxazoline)s. To develop polymers tailored for the maximum efficiency of drug encapsulation, the synthetic part will be guided by computational studies on the relationship between the structures of the polymers and their thermodynamic compatibility with model compounds and selected drugs.

grapghical abstract A01 Image: C. Weber, M. Sierka

Principle investigators:

Prof. Dr. Ulrich S. Schubert

Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de

Prof. Dr. Marek Sierka

Otto  Schott Institute of Materials Research (OSIM)
Friedrich Schiller University of Jena
Löbdergraben 32
07743 Jena
Phone: +49 3641 9-47930
marek.sierka@uni-jena.de

Staff:

Irina Muljajew
Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48581
irina.muljajew@uni-jena.de

Andreas Erlebach
Otto  Schott Institute of Materials Research (OSIM)
Löbdergraben 32, 07743 Jena
Phone: +49 3641 9-47785
andreas.erlebach@uni-jena.de

 

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