Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions
A chemist uses a pipette to introduce cell samples into a so-called microtiter plate.
The aim of this project is to design multifunctional core-shell-corona micelles with controllable size, net charge, and charge density that allow for cell-type specific delivery of siRNA into hepatocytes while deliberately avoiding macrophages. Covalent placement of targeting dyes on the surface of the nanostructures (e.g., polymethine dyes) will be a strategy to achieve an efficient and cell-type specific delivery of phosphoinositid-3-kinase (PI3K)-γ attacking substances reflecting a promising strategy to prevent sepsis-associated hepatic dysfunction.
Image: F. Schacher
Prof. Dr. Michael Bauer
Center for Sepsis Control and Care (CSCC) University Hospital Jena (UKJ) Erlanger Allee 101 07747 Jena Phone: +49 3641 9-323110 firstname.lastname@example.org