A chemist uses a pipette to introduce cell samples into a so-called microtiter plate.

C03

Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions

A chemist uses a pipette to introduce cell samples into a so-called microtiter plate.

The aim of this project is to design multifunctional core-shell-corona micelles with controllable size, net charge, and charge density that allow for cell-type specific delivery of siRNA into hepatocytes while deliberately avoiding macrophages. Covalent placement of targeting dyes on the surface of the nanostructures (e.g., polymethine dyes) will be a strategy to achieve an efficient and cell-type specific delivery of phosphoinositid-3-kinase (PI3K)-γ attacking substances reflecting a promising strategy to prevent sepsis-associated hepatic dysfunction.

Image: F. Schacher

Principle investigators:

Prof. Dr. Michael Bauer

Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Erlanger Allee 101
07747 Jena
Phone: +49 3641 9-323110
michael.bauer@med.uni-jena.de

Prof. Dr. Britta Qualmann

Institute of Biochemistry I
University Hospital Jena
Nonnenplan 2-4
07743 Jena
Phone: +49 3641 9-396300
britta.qualmann@med.uni-jena.de

Prof. Dr. Felix H. Schacher

Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University of Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48250
felix.schacher@uni-jena.de

Staff:

Wanling Foo
Center for Sepsis Control and Care (CSCC)
University Hospital Jena (UKJ)
Erlanger Allee 101, 07747 Jena
Phone: +49 3641 9-323110
wanling.foo@med.uni-jena.de

Annemarie Landmann
Institute of Biochemistry I
University Hospital Jena
Nonnenplan 2-4, 07743 Jena
Phone: +49 3641 9-38637
Annemarie.Landmann@med.uni-jena.de

Moritz Köhler
Institute of Organic Chemistry and Macromolecular Chemistry (IOMC)
Humboldtstraße 10, 07743 Jena
Phone: +49 3641 9-48251
moritz.koehler@uni-jena.de