test tubes containing pink fuid

C02

Exploiting polymer-based delivery systems for anti-inflammatory indirubin-based 6BIGOE derivatives in in vitro and in vivo proof-of-principle studies
test tubes containing pink fuid

Indirubin-derived 6BIGOE potently inhibits pro-inflammatory interleukin(IL)-1β and prostaglandin (PG)E2 release in human monocytes with unknown mode of action, which shall be revealed. Because of inappropriate physicochemical properties, 6BIGOE shall be encapsulated into nanoparticles based on polymers of lactic and glycolic acid, stabilized by stealth polymers and targeted with e.g. Arg-Gly-Asp (RGD) ligands. Bioactivities will be tested in primary human monocytes/macrophages and their co-cultures with endothelial cells as well as in the HET-CAV (hen’s egg test – chick area vasculosa).

graphical abstract C02 Image: D. Fischer

Principle Investigators:

Prof. Dr. Dagmar Fischer

Institute of Pharmacy (IP)
Friedrich Schiller University of Jena
Lessingstrasse 8
07743 Jena
Phone: +49 3641 9-49941
dagmar.fischer@uni-jena.de

Prof. Dr. Oliver Werz

Institute of Pharmacy (IP)
Friedrich Schiller University of Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801
oliver.werz@uni-jena.de

Staff:

Christian Grune
Institute of Pharmacy (IP)
Otto-Schott-Straße 41, 07745 Jena
Phone: +49 3641 9-49925
christian.grune@uni-jena.de

Anna Czapka
Institute of Pharmacy (IP)
Philosophenweg 14, 07743 Jena
Phone: +49 3641 9-49616
anna.czapka@uni-jena.de

 

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