Cell tissue on the monitor of a fluorescence microscope.

B06

Circumventing the immune response by targeted nanoparticle mediated delivery of nucleic acids
Cell tissue on the monitor of a fluorescence microscope.

The main goal of the current project is to develop targeted nanoparticle mediated delivery of nucleic acids for in vivo applications crossing the endothelial barrier and avoiding immunogenic recognition. Therefore, the preparation of mRNA loaded nanoparticles and the characterization thereof regarding physico-chemical and biological aspects will be realized. The particles will be tested in an advanced cell culture setup using a fluidic approach combined with co-cultivation. Different aspects, such as cellular targeting and uptake of nanoparticles, endosomal release and intercellular delivery of mRNA as well as efficiency of nanoparticle mediated gene delivery will be addressed. Design parameters like size, surface charge, particle density, and the balance between active and passive targeting will be investigated within the project.

Principle investigators:

Dr. Anja Träger

Particle Formulation Group (PFG)
Jena Center for Soft Matter (JCSM)
Friedrich Schiller University of Jena
Philosophenweg 7
07743 Jena
Phone: +49 3641 9-48599
anja.traeger@uni-jena.de

Staff:

Jana Salomun
Jena Center for Soft Matter (JCSM)
Philosophenweg 7, 07743 Jena
Phone: +49 3641 9-48575
jana.salomun@uni-jena.de

Prosper Mapfumo
Jena Center for Soft Matter (JCSM)
Philosophenweg 7, 07743 Jena
Phone: +49 3641 9-48587
prosper.mapfumo@uni-jena.de

 

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