Photo-triggered swelling and release from core-shell-corona micelles
Fluorescent solutions in the synthesis laboratory
The goal of this project is to design and characterize (spectroscopically and mechanistically) core-shell-corona nanostructures for visible light-induced spatially and temporally selective delivery of medically active components. We utilize amphiphilic ABC triblock terpolymers for the formation of micelles where the core is capable of chemical up-conversion by triplet-triplet annihilation of low-intensity long-wavelength light to higher-energy photons, which then are capable of activating photoacids in the shell. This then induces swelling and, on a longer perspective, triggered release.